{"id":10018,"date":"2024-10-15T06:00:00","date_gmt":"2024-10-15T11:00:00","guid":{"rendered":"https:\/\/cov19longhaulfoundation.org\/?p=10018"},"modified":"2024-07-06T09:17:07","modified_gmt":"2024-07-06T14:17:07","slug":"il-13-decreases-susceptibility-to-airway-epithelial-sars-cov-2-infection-but-increases-disease-severity-in-vivo","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=10018","title":{"rendered":"IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo"},"content":{"rendered":"\n<p class=\"has-small-font-size wp-block-paragraph\">Shreya\u00a0Ghimire,\u00a0Biyun\u00a0Xue,\u00a0Kun\u00a0Li,\u00a0Ryan M\u00a0Gannon,\u00a0et. al.<strong>doi:<\/strong>\u00a0https:\/\/doi.org\/10.1101\/2024.07.03.60194<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"p-2\">Treatments available to prevent progression of virus-induced lung diseases, including coronavirus disease 2019 (COVID-19) are of limited benefit once respiratory failure occurs. The efficacy of approved and emerging cytokine signaling-modulating antibodies is variable and is affected by disease course and patient-specific inflammation patterns. Therefore, understanding the role of inflammation on the viral infectious cycle is critical for effective use of cytokine-modulating agents. We investigated the role of the type 2 cytokine IL-13 on SARS-CoV-2 binding\/entry, replication, and host response in primary HAE cells in vitro and in a model of mouse-adapted SARS-CoV-2 infection in vivo. IL-13 protected airway epithelial cells from SARS-CoV-2 infection in vitro by decreasing the abundance of ACE2- expressing ciliated cells rather than by neutralization in the airway surface liquid or by interferon-mediated antiviral effects. In contrast, IL-13 worsened disease severity in mice; the effects were mediated by eicosanoid signaling and were abolished in mice deficient in the phospholipase A2 enzyme PLA2G2D. We conclude that IL-13-induced inflammation differentially affects multiple steps of COVID-19 pathogenesis. IL-13-induced inflammation may be protective against initial SARS-CoV-2 airway epithelial infection; however, it enhances disease progression in vivo. Blockade of IL-13 and\/or eicosanoid signaling may be protective against progression to severe respiratory virus-induced lung disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shreya\u00a0Ghimire,\u00a0Biyun\u00a0Xue,\u00a0Kun\u00a0Li,\u00a0Ryan M\u00a0Gannon,\u00a0et. al.doi:\u00a0https:\/\/doi.org\/10.1101\/2024.07.03.60194 Abstract Treatments available to prevent progression of virus-induced lung diseases, including coronavirus disease 2019 (COVID-19) are of limited benefit once respiratory failure occurs. The efficacy of approved [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":10020,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[106,151,1069,252],"tags":[],"class_list":["post-10018","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cytokine-storm","category-epithelium","category-il-13","category-inflammation"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/10018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10018"}],"version-history":[{"count":1,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/10018\/revisions"}],"predecessor-version":[{"id":10019,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/10018\/revisions\/10019"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/10020"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}