{"id":10389,"date":"2025-01-10T06:00:00","date_gmt":"2025-01-10T11:00:00","guid":{"rendered":"https:\/\/cov19longhaulfoundation.org\/?p=10389"},"modified":"2024-08-01T10:53:14","modified_gmt":"2024-08-01T14:53:14","slug":"two-year-longitudinal-study-reveals-that-long-covid-symptoms-peak-and-quality-of-life-nadirs-at-6-12-months-postinfection-3","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=10389","title":{"rendered":"Two-Year Longitudinal Study Reveals That Long COVID Symptoms Peak and Quality of Life Nadirs at 6\u201312 Months Postinfection\u00a0"},"content":{"rendered":"\n<p class=\"has-small-font-size\">Zoe O Demko,\u00a0Tong Yu,\u00a0Sarika K Mullapudi,\u00a0M Gabriela Varela Heslin,\u00a0et. al.<em>Open Forum Infectious Diseases<\/em>, Volume 11, Issue 3, March 2024, ofae027,\u00a0<a href=\"https:\/\/doi.org\/10.1093\/ofid\/ofae027\">https:\/\/doi.org\/10.1093\/ofid\/ofae027<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"445613685\">Abstract<\/h2>\n\n\n\n<p>Background<\/p>\n\n\n\n<p>Few longitudinal studies available characterize long COVID outcomes out to 24 months, especially in people with nonsevere acute coronavirus disease 2019 (COVID-19). This study sought to prospectively characterize incidence and duration of long COVID symptoms and their association with quality of life (QoL) from 1\u201324 months after mild-to-moderate COVID-19 using validated tools in a diverse cohort of unvaccinated people infected with SARS-CoV-2 in 2020.<\/p>\n\n\n\n<p>Methods<\/p>\n\n\n\n<p>At 1\u20133, 6, 12, 18, and 24 months post-COVID-19, 70 participants had orthostatic vital signs measured, provided blood, and completed surveys characterizing symptoms, QoL, and return to pre-COVID-19 health and activities using validated tools (FLU-PRO+, Fatigue Severity Scale, Insomnia Severity Index, General Practitioner Assessment of Cognition, Patient Health Questionnaire Depression 8-Item, Generalized Anxiety Disorder 7-Item, 36-Item Short-Form Health Survey, EuroQol EQ-5D-5L).<\/p>\n\n\n\n<p>Results<\/p>\n\n\n\n<p>During the study period, 33% of participants experienced long COVID (had not returned to pre-COVID-19 health status and reported at least 1 symptom &gt;90 days postinfection); 8% had not returned to their pre-COVID-19 health status 24 months postinfection. Long COVID symptoms peaked 6 months post-COVID-19, frequently causing activity limitations. Having long COVID was significantly associated with decreased QoL in multiple domains. Frequencies of orthostatic hypotension and tachycardia reflected levels reported in the general population. Within-person weight increased significantly between months 1 and 6. Long COVID was associated with pre-COVID-19 obesity and hyperlipidemia, but not with high-sensitivity C-reactive protein levels 1\u20133 months postinfection.<\/p>\n\n\n\n<p>Conclusions<\/p>\n\n\n\n<p>Long COVID occurs in a significant proportion of unvaccinated people, even if the acute illness was not severe. Long COVID prevalence peaked 6\u201312 months post-COVID-19, and a small proportion of participants still reported not returning to their pre-COVID-19 health status 24 months post-COVID-19.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zoe O Demko,\u00a0Tong Yu,\u00a0Sarika K Mullapudi,\u00a0M Gabriela Varela Heslin,\u00a0et. al.Open Forum Infectious Diseases, Volume 11, Issue 3, March 2024, ofae027,\u00a0https:\/\/doi.org\/10.1093\/ofid\/ofae027 Abstract Background Few longitudinal studies available characterize long COVID outcomes [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":10404,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[94,149,169,843,289,290,1085,536],"tags":[],"class_list":["post-10389","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cognitive-deficit","category-epidemiology","category-fatigure","category-insomnia","category-long-haul-disease","category-long-term-effects","category-quality-of-life","category-sleep"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/10389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10389"}],"version-history":[{"count":1,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/10389\/revisions"}],"predecessor-version":[{"id":10390,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/10389\/revisions\/10390"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/10404"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}