{"id":1124,"date":"2021-07-27T19:50:42","date_gmt":"2021-07-27T19:50:42","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=1124"},"modified":"2021-07-27T19:50:42","modified_gmt":"2021-07-27T19:50:42","slug":"initial-study-on-tmprss2-p-val160met-genetic-variant-in-covid-19-patients","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=1124","title":{"rendered":"Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients"},"content":{"rendered":"\n

Authors: Laksmi Wulandari<\/a>,\u00a0Berliana Hamidah<\/a>,\u00a0Cennikon Pakpahan<\/a>,\u00a0Nevy Shinta Damayanti<\/a>,\u00a0Neneng Dewi Kurniati<\/a>,\u00a0Christophorus Oetama Adiatmaja<\/a>,\u00a0Monica Rizky Wigianita<\/a>,\u00a0Soedarsono<\/a>,\u00a0Dominicus Husada<\/a>,\u00a0Damayanti Tinduh<\/a>,\u00a0Cita Rosita Sigit Prakoeswa<\/a>,\u00a0Anang Endaryanto<\/a>,\u00a0Ni Nyoman Tri Puspaningsih<\/a>,\u00a0Yasuko Mori<\/a>,\u00a0Maria Inge Lusida<\/a>,\u00a0Kazufumi Shimizu<\/a>\u00a0&\u00a0Delvac Oceandy<\/a>\u00a0<\/p>\n\n\n\n

Coronavirus disease 2019 (COVID-19) is a global health problem that causes millions of deaths worldwide. The clinical manifestation of COVID-19 widely varies from asymptomatic infection to severe pneumonia and systemic inflammatory disease. It is thought that host genetic variability may affect the host\u2019s response to the virus infection and thus cause severity of the disease. The SARS-CoV-2 virus requires interaction with its receptor complex in the host cells before infection. The transmembrane protease serine 2 (TMPRSS2) has been identified as one of the key molecules involved in SARS-CoV-2 virus receptor binding and cell invasion. Therefore, in this study, we investigated the correlation between a genetic variant within the human\u00a0TMPRSS2<\/em>\u00a0gene and COVID-19 severity and viral load.<\/p>\n\n\n\n

For More Information: https:\/\/humgenomics.biomedcentral.com\/articles\/10.1186\/s40246-021-00330-7<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Laksmi Wulandari,\u00a0Berliana Hamidah,\u00a0Cennikon Pakpahan,\u00a0Nevy Shinta Damayanti,\u00a0Neneng Dewi Kurniati,\u00a0Christophorus Oetama Adiatmaja,\u00a0Monica Rizky Wigianita,\u00a0Soedarsono,\u00a0Dominicus Husada,\u00a0Damayanti Tinduh,\u00a0Cita Rosita Sigit Prakoeswa,\u00a0Anang Endaryanto,\u00a0Ni Nyoman Tri Puspaningsih,\u00a0Yasuko Mori,\u00a0Maria Inge Lusida,\u00a0Kazufumi Shimizu\u00a0&\u00a0Delvac Oceandy\u00a0 Coronavirus disease 2019 […]<\/p>\n","protected":false},"author":2,"featured_media":1125,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[155,189],"tags":[],"class_list":["post-1124","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-etiology","category-genomics"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1124"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1124\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/1125"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}