{"id":12207,"date":"2025-08-28T06:00:00","date_gmt":"2025-08-28T10:00:00","guid":{"rendered":"https:\/\/cov19longhaulfoundation.org\/?p=12207"},"modified":"2025-05-23T09:28:31","modified_gmt":"2025-05-23T13:28:31","slug":"long-covid-sleep-disturbances-phenotypes-and-risk-factors-from-a-safety-net-hospital","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=12207","title":{"rendered":"Long COVID Sleep Disturbances: Phenotypes and Risk Factors from a Safety-Net Hospital"},"content":{"rendered":"\n

Angela Sohng\u00a0,\u00a0Ariana Rauch\u00a0,\u00a0Neoreet Braha\u00a0,\u00a0et. al., Sleep<\/em>, Volume 48, Issue Supplement_1, May 2025, Page A605,\u00a0https:\/\/doi.org\/10.1093\/sleep\/zsaf090.1407<\/a><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Introduction<\/h3>\n\n\n\n

Millions globally suffer from long-term functional and cognitive impairment from post-acute-SARS-CoV-2 infection (PASC), or \u201cLong COVID.\u201d Sleep disturbances (SDs), either new or exacerbated, are common but under-researched in this population despite their impact on immune function, chronic organ illness, and quality of life.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

Retrospective chart review of patients seen at Boston Medical Center\u2019s Long COVID Clinic (01\/2022-12\/2023). SDs experienced during PASC were classified into four phenotypes: insomnia, hypersomnia, mixed, and other. Binomial and multinomial regression identified predictors, with no SD as the reference and Area Deprivation Index (ADI) as the covariate. P-values were adjusted for multiplicity using the Benjamini-Hochberg method.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

Among 452 PASC patients (median age 47, 70.4% Female, 46% White), 28.1% had no SD, while 34.7% reported insomnia, 9.3% hypersomnia, 20.8% mixed insomnia\/hypersomnia, and 6.9% other SDs. ADI was the only significant demographic predictor of SD (p=.016); vaccination status, number of infections, and hospitalizations were not predictive. Comorbidities strongly linked to SD-Insomnia included pre-existing insomnia (OR=3.97, p<.01), chronic pain (OR=2.75, p<.01), anxiety (OR=2.24, p<.01), and depression (OR=1.98, p=.024). These also predicted SD-Mixed insomnia\/hypersomnia. Additionally, chronic heart disease (OR=5.02, p=.024), OSA (OR=3.16, p=.022), and chronic pulmonary disease (OR=2.76, p<.01) were specifically associated with SD-Mixed. No comorbidities predicted hypersomnia. PASC symptom predictors (all p<.01) included fatigue, post-exertional malaise (PEM), brain fog, anxiety, depression, and POTS\/dysautonomia. SD-Hypersomnia was notably associated with PEM (OR=10.39, p<.01), gait instability (OR=9.12, p=.012), and POTS\/dysautonomia (OR=8.09, p<.01). SD-Mixed was especially defined by fatigue (OR=18.5, p<.01) and PEM (OR=10.93, p<.01). Notable medication risk factors for SD-Insomnia included benzodiazepines (OR=3.53, p<.01) and PPIs (OR=2.22, p=.033). Beta-blockers (OR=3.46, p=.024) and albuterol (OR=3.40, p<.01) were stronger predictors of SD-Mixed but also significant for SD-Insomnia.<\/p>\n\n\n\n

Conclusion<\/h3>\n\n\n\n

SD-Insomnia and SD-Mixed were strongly linked to pre-existing comorbidities, PASC symptoms, and medications, while SD-Hypersomnia was primarily driven by PASC-related symptoms. Treatment strategies should be tailored based on SD phenotypes: addressing comorbidities and minimizing iatrogenic effects for SD-Insomnia and SD-Mixed, while targeting PASC symptoms of autonomic dysfunction, PEM, and gait instability for SD-Hypersomnia. Recognizing these distinct patterns may improve personalized management of sleep disturbances in PASC.<\/p>\n","protected":false},"excerpt":{"rendered":"

Angela Sohng\u00a0,\u00a0Ariana Rauch\u00a0,\u00a0Neoreet Braha\u00a0,\u00a0et. al., Sleep, Volume 48, Issue Supplement_1, May 2025, Page A605,\u00a0https:\/\/doi.org\/10.1093\/sleep\/zsaf090.1407 Abstract Introduction Millions globally suffer from long-term functional and cognitive impairment from post-acute-SARS-CoV-2 infection (PASC), or […]<\/p>\n","protected":false},"author":2,"featured_media":12210,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[101,421,949],"tags":[],"class_list":["post-12207","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","category-pasc","category-sleep-disturbance"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/12207","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12207"}],"version-history":[{"count":2,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/12207\/revisions"}],"predecessor-version":[{"id":12209,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/12207\/revisions\/12209"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/12210"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}