{"id":12596,"date":"2025-06-30T18:00:00","date_gmt":"2025-06-30T22:00:00","guid":{"rendered":"https:\/\/cov19longhaulfoundation.org\/?p=12596"},"modified":"2025-06-29T20:21:56","modified_gmt":"2025-06-30T00:21:56","slug":"six-questions-about-covid-19-vaccines-answered","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=12596","title":{"rendered":"Six Questions About Covid-19 Vaccines, Answered"},"content":{"rendered":"\n<p class=\"has-small-font-size\">Story by&nbsp;Shreyas Teegala and Simar Baja<\/p>\n\n\n\n<p>Experts say those patients at the highest risk of developing severe illness should get vaccinated.\u00a9&nbsp;Andriy Onufriyenko, Moment via Getty Images<\/p>\n\n\n\n<p>Since the first Covid-19 vaccines were authorized in&nbsp;<a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/history-disease-outbreaks-vaccine-timeline\/covid-19\" target=\"_blank\" rel=\"noreferrer noopener\">December 2020<\/a>, more than&nbsp;<a href=\"https:\/\/coronavirus.jhu.edu\/vaccines\/international\" target=\"_blank\" rel=\"noreferrer noopener\">672 million doses<\/a>&nbsp;have been administered in the United States. For years, the Centers for Disease Control and Prevention (CDC) has broadly recommended up-to-date vaccination, which more recently includes Covid shots, for nearly all age groups to reduce the risk of severe disease and death.<\/p>\n\n\n\n<p>Vaccine policy is usually decided by a group of outside experts\u2014the&nbsp;<a href=\"https:\/\/www.cdc.gov\/acip\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\">Advisory Committee on Immunization Practices<\/a>, which holds a public meeting to review vaccine data, take questions, vote on recommendations, and then advise the director of the CDC accordingly.<\/p>\n\n\n\n<p>But, Health and Human Services Secretary Robert F. Kennedy Jr. departed from this protocol via a post on\u00a0<a href=\"https:\/\/x.com\/SecKennedy\/status\/1927368440811008138\" target=\"_blank\" rel=\"noreferrer noopener\">X<\/a>. Two weeks before the committee was scheduled to\u00a0<a href=\"https:\/\/www.federalregister.gov\/documents\/2025\/06\/09\/2025-10432\/meeting-of-the-advisory-committee-on-immunization-practices\" target=\"_blank\" rel=\"noreferrer noopener\">meet<\/a>, Kennedy announced that two groups, specifically pregnant women and healthy children, would\u00a0<a href=\"https:\/\/apnews.com\/article\/covid-vaccine-pregnant-women-children-70c358cad726e57d680234c3ecdec926\" target=\"_blank\" rel=\"noreferrer noopener\">no longer be recommended<\/a>\u00a0to receive Covid vaccines. He did not mention recommendations for other populations.<\/p>\n\n\n\n<p>The move was unprecedented and controversial.<\/p>\n\n\n\n<p>The landscape was further muddled by the CDC announcing that the Covid-19 vaccines would remain on the childhood immunization schedule,&nbsp;<a href=\"https:\/\/www.nytimes.com\/2025\/05\/30\/health\/cdc-covid-vaccines-children-pregnant-women.html?campaign_id=190&amp;emc=edit_ufn_20250530&amp;instance_id=155606&amp;nl=from-the-times&amp;regi_id=39194065&amp;segment_id=198999&amp;user_id=cb9522b0c5b32ef5419e62a8d1ee5cdb\" target=\"_blank\" rel=\"noreferrer noopener\">contradicting<\/a>&nbsp;RFK Jr.\u2019s decree. \u201cWe\u2019re in a little bit of uncharted waters,\u201d says&nbsp;<a href=\"https:\/\/www.immunizationmanagers.org\/staff-member\/dr-michelle-fiscus\/\" target=\"_blank\" rel=\"noreferrer noopener\">Michelle Fiscus<\/a>, the chief medical officer of the nonprofit&nbsp;<a href=\"https:\/\/www.immunizationmanagers.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Association of Immunization Managers<\/a>.<a target=\"_blank\" href=\"https:\/\/www.msn.com\/en-us\/video\/health\/what-are-mrna-vaccines\/vi-AA1E63lq\" rel=\"noreferrer noopener\">Related video:&nbsp;What are mRNA vaccines?&nbsp;(STAT News Video &#8211; Video)<\/a><\/p>\n\n\n\n<figure class=\"wp-block-video\"><\/figure>\n\n\n\n<p>Loaded:&nbsp;9.82%Play<img decoding=\"async\" src=\"https:\/\/assets.msn.com\/staticsb\/statics\/latest\/views\/icons\/video\/videoSeekBack.svg\"><img decoding=\"async\" src=\"https:\/\/assets.msn.com\/staticsb\/statics\/latest\/views\/icons\/video\/videoSeekForward.svg\"><\/p>\n\n\n\n<p>Current Time&nbsp;0:00<\/p>\n\n\n\n<p>\/<\/p>\n\n\n\n<p>Duration&nbsp;2:02Quality SettingsCaptionsFullscreen<\/p>\n\n\n\n<p><img decoding=\"async\" src=\"https:\/\/img-s-msn-com.akamaized.net\/tenant\/amp\/entityid\/AA1zeG63.img?w=16&amp;h=16&amp;q=60&amp;m=6&amp;f=jpg&amp;u=t\" alt=\"\">STAT News Video &#8211; Video<\/p>\n\n\n\n<p>What are mRNA vaccines?Unmute<\/p>\n\n\n\n<p>0<\/p>\n\n\n\n<p><a href=\"https:\/\/www.msn.com\/en-us\/video\/health\/what-are-mrna-vaccines\/vi-AA1E63lq\" target=\"_blank\" rel=\"noreferrer noopener\">View on Watch<\/a><\/p>\n\n\n\n<p>And what started as a pre-emptive sidestep escalated to an elimination and then replacement. On Monday,&nbsp;<a href=\"https:\/\/www.nytimes.com\/2025\/06\/09\/health\/rfk-jr-cdc-vaccine-panel.html\" target=\"_blank\" rel=\"noreferrer noopener\">RFK Jr. fired all 17 members of the Advisory Committee on Immunization Practices,<\/a>&nbsp;claiming the panel needed to be&nbsp;<a href=\"https:\/\/www.wsj.com\/opinion\/rfk-jr-hhs-moves-to-restore-public-trust-in-vaccines-45495112?mod=Searchresults_pos4&amp;page=1\" target=\"_blank\" rel=\"noreferrer noopener\">reconstituted to avoid conflicts of interest<\/a>&nbsp;that he says preclude sufficient scrutiny of vaccines. On Wednesday, he named eight new members to the committee, including four, as&nbsp;<a href=\"https:\/\/www.nytimes.com\/2025\/06\/11\/us\/politics\/rfk-jr-cdc-vaccine-panel.html\" target=\"_blank\" rel=\"noreferrer noopener\">the&nbsp;<em>New York Times<\/em>&nbsp;reported<\/a>, \u201cwho have spoken out against vaccination in some way.\u201d The changes add to the uncertainty about how immunization policy will be developed and whether the burden of paying for vaccines will shift more to patients, rather than insurers.<\/p>\n\n\n\n<p>These recent developments have left many people confused about the updated Covid-19 vaccines and who should be taking them. So we consulted vaccine and public health experts to help make sense of the recent changes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What\u2019s the difference between a booster and an updated vaccine?<\/h2>\n\n\n\n<p>When Covid-19 vaccines first became available, they were administered as one or two doses, protecting against&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33985964\/\" target=\"_blank\" rel=\"noreferrer noopener\">severe illness and death<\/a>. But immunity&nbsp;<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2115481\" target=\"_blank\" rel=\"noreferrer noopener\">wanes over time<\/a>, Fiscus says, so booster vaccines, or additional doses of the primary series, were introduced to maintain protection\u2014even if only in the&nbsp;<a href=\"https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/1050236\/technical-briefing-34-14-january-2022.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">short<\/a>&nbsp;<a href=\"https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/1046488\/S1482_Warwick_Omicron_5_1_2022.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">term<\/a>.<\/p>\n\n\n\n<p>As the pandemic progressed, new variants like Delta and Omicron emerged and&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s41590-025-02162-2\" target=\"_blank\" rel=\"noreferrer noopener\">evaded vaccine protection<\/a>, prompting the need for&nbsp;<a href=\"https:\/\/publichealth.jhu.edu\/Bivalent-Covid-19-Booster-Updates\" target=\"_blank\" rel=\"noreferrer noopener\">new targeted formulations<\/a>, she continues. So repeated doses of the original vaccine, or boosters, were replaced with updated vaccines \u2014 new compositions that better match circulating viral strains.<\/p>\n\n\n\n<p>So when it comes to the latest recommendations, \u201cwe\u2019re not talking about boosters anymore, Fiscus says. \u201cWe\u2019re talking about new vaccines.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Who should get the updated Covid-19 vaccine?<\/h2>\n\n\n\n<p>Simply put, those at the highest risk of developing severe illness.<\/p>\n\n\n\n<p>Adults over age 65 and people with compromised immune systems are&nbsp;<a href=\"https:\/\/www.cdc.gov\/vaccines\/hcp\/imz-schedules\/adult-age.html\" target=\"_blank\" rel=\"noreferrer noopener\">clear examples<\/a>, says&nbsp;<a href=\"https:\/\/healthpolicy.ucsf.edu\/profile\/anil-makam\" target=\"_blank\" rel=\"noreferrer noopener\">Anil Makam<\/a>, a hospital medicine physician at the University of California, San Francisco\u2014because they\u2019re more likely to&nbsp;<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s40121-025-01160-z\" target=\"_blank\" rel=\"noreferrer noopener\">be hospitalized<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9250925\/\" target=\"_blank\" rel=\"noreferrer noopener\">die of Covid-19<\/a>.<\/p>\n\n\n\n<p>So the CDC\u2019s recent choice to drop healthy pregnant women from its recommendations was confusing. \u201cPregnancy is probably the highest dynamic risk condition,\u201d says&nbsp;<a href=\"https:\/\/physiciandirectory.brighamandwomens.org\/details\/13177\/jeremy-faust-emergency_medicine-boston\" target=\"_blank\" rel=\"noreferrer noopener\">Jeremy Faust<\/a>, an emergency physician at Brigham and Women\u2019s Hospital, because it puts otherwise healthy women in vulnerable positions<\/p>\n\n\n\n<p>This is because pregnancy suppresses the expecting mother\u2019s immune system,&nbsp;<a href=\"https:\/\/www.childrenshospital.org\/directory\/ofer-levy\" target=\"_blank\" rel=\"noreferrer noopener\">says Ofer Levy<\/a>, a pediatrician and director of the&nbsp;<a href=\"https:\/\/research.childrenshospital.org\/research-units\/pediatrics-research\/precision-vaccines-program\" target=\"_blank\" rel=\"noreferrer noopener\">Precision Vaccines Program<\/a>&nbsp;at Boston Children\u2019s Hospital, so that it doesn\u2019t attack the fetus as a foreign pathogen. The updated vaccines can thus help pregnant women stay protected.<\/p>\n\n\n\n<p>The Covid-19 vaccines can also protect the newborn\u2014one of the highest-risk groups for hospitalization\u2014since taking a dose during pregnancy confers maternal antibodies to the fetus, Faust says. Because data on the safety of vaccinating children under 6 months isn\u2019t available, vaccinating pregnant women is the best way to protect babies over that period, he continues.<\/p>\n\n\n\n<p>But some experts feel these benefits will likely be modest. For example, since most pregnant women have already received the primary vaccine series, they will still have Covid-19 antibodies in their blood and be able to transfer some to their fetus via the&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9203883\/\" target=\"_blank\" rel=\"noreferrer noopener\">placenta or breast milk<\/a>. So the real question, Makam says, is what additional protection does another dose provide beyond the immunity they already have? While the evidence on the marginal benefits of updated vaccines isn\u2019t definitive, Faust says they still make sense to help prevent severe disease complications for mother and child. He reminds that \u201cthe maternal mortality during Covid was extraordinarily terrible, and it&#8217;s gotten a lot better due to vaccines.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do healthy people need an updated vaccine?<\/h2>\n\n\n\n<p>The general public health recommendation: probably not. \u201cHigher risk and older populations should stay up to date on Covid vaccines,\u201d Faust says. \u201cEveryone else may.\u201d<\/p>\n\n\n\n<p>It comes back to the same question about extra doses: \u201cIf you\u2019re getting one every cycle, the benefits are probably minimally advantageous and short-lived,\u201d Makam says.<\/p>\n\n\n\n<p>But while the decision to get a vaccine is binary, informed decisions exist on a spectrum. \u201cI am 59 years old, so I\u2019m not yet considered elderly. But I&#8217;m at higher risk than somebody who\u2019s 20,\u201d Levy says. \u201cWhere do you draw that line?\u201d<\/p>\n\n\n\n<p>As such, the choice to receive an updated vaccine should be made with a trusted health care provider, who can weigh medical history, local Covid-19 trends and household circumstances, he continues. Physicians sometimes call this process \u201cshared decision-making.\u201d<\/p>\n\n\n\n<p>The same logic generally holds for children. Since they have the least exposure to the virus, they definitely should get vaccinated for Covid-19 if they haven\u2019t before, Faust says. But for those who are healthy and have already gotten the original series, the updated vaccine may only offer limited benefits, so further vaccination should be considered on a case-by-case basis by pediatricians and families.<\/p>\n\n\n\n<p>Still, some caution is warranted, especially for adolescent boys and young men, the one group with a consistently observed\u2014albeit small\u2014risk of&nbsp;<a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/myocarditis\/symptoms-causes\/syc-20352539\" target=\"_blank\" rel=\"noreferrer noopener\">myocarditis<\/a>, an inflammation of the heart muscle, Makam says. Given this drawback and the likely minimal benefits, he suggests that an updated vaccine may not be worth it for this group. That said, the landscape is shifting: The risk of myocarditis has decreased significantly with updated vaccines, Faust notes, offering reassurance as families and clinicians weigh their options.<\/p>\n\n\n\n<p>To summarize, for healthy people already vaccinated by the primary series, an updated dose may or may not be necessary, but this decision should come from a conversation between families and their providers, according to Levy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Should anyone avoid the updated vaccine?<\/h2>\n\n\n\n<p>People who\u2019ve had myocarditis shortly after a previous dose or have faced multisystem inflammatory syndrome, a rare Covid-19 complication, should avoid the vaccine if possible and take&nbsp;<a href=\"https:\/\/www.cdc.gov\/covid\/hcp\/vaccine-considerations\/contraindications-precautions.html\" target=\"_blank\" rel=\"noreferrer noopener\">significant precautions<\/a>&nbsp;if not. But the only absolute deterrent is a history of severe allergies to a previous dose\u2014a common-sense one. \u201cIf you had a serious reaction to an mRNA vaccine, you should think twice before getting another,\u201d Levy says.<\/p>\n\n\n\n<p>Otherwise, the evidence does not support any general safety concerns. \u201cWhat often gets lost in the conversation is just how safe these vaccines have proven to be,\u201d Faust says. The primary series clinical trials enrolled tens of thousands of participants\u2014massive studies that helped establish a strong safety profile early on. \u201cThe risk of serious side effects was always low\u2014and it\u2019s only gotten lower,\u201d he continues.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">When are updated vaccines coming out?<\/h2>\n\n\n\n<p>In August or September, pharmaceutical companies will update the precise composition of the Covid-19 and flu vaccines, following recommendations from the Food and Drug Administration (FDA). The goal is to match the circulating strains as closely as possible, Levy says.<\/p>\n\n\n\n<p>For the upcoming season, the FDA has recommended a vaccine targeting the LP.8.1 strain, a close cousin of&nbsp;<a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-and-authorizes-updated-mrna-covid-19-vaccines-better-protect-against-currently\" target=\"_blank\" rel=\"noreferrer noopener\">last year\u2019s strain<\/a>\u2014both variants belonging to the same lineage. \u201cSo there\u2019s no big change in the makeup of Covid-19 vaccines,\u201d Fiscus says.<\/p>\n\n\n\n<p>While year-to-year changes may seem marginal, Faust explains that they\u2019re part of a cumulative process to keep up with this ever-changing virus. So while the decision to get an updated vaccine will depend on individual factors, staying current remains a reasonable strategy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If the new recommendations don\u2019t include me, can I still get the updated Covid-19 vaccine?<\/h2>\n\n\n\n<p>You will still likely be able to receive the updated vaccine, but it might cost you.<\/p>\n\n\n\n<p>After all, the guidelines explicitly allow for shared decision-making. \u201cIt doesn\u2019t mean you can\u2019t prescribe things just because there\u2019s not an FDA indication; it means you\u2019ll talk to your doctor,\u201d Makam says\u2014and decide if the vaccine is appropriate and should be given.<\/p>\n\n\n\n<p>The issue is that, with this shift away from universal recommendations, insurance coverage becomes less certain. Per the Affordable Care Act, if the Advisory Committee on Immunization Practices recommends a vaccine, then private insurers have to cover it. But without a federal recommendation and now without a committee to advise one, vaccine access may fall into financial limbo. \u201cYou could end up with a scenario where it\u2019s technically possible to get immunized, but there are administrative and financial barriers to doing so,\u201d Levy says.<\/p>\n\n\n\n<p>And that cost burden will fall unevenly, with potential costs varying based on an individual\u2019s insurance plan. \u201cIf you\u2019re going to have to pay out of pocket\u2014$10, $20, $50, $100\u2014that might be enough to sway people who were on the fence,\u201d Makam says.<\/p>\n\n\n\n<p>Thus, whether a vaccine is officially recommended can influence whether it\u2019s covered\u2014so even if a doctor advises it, patients might still have to pay on their own dime. In other words, tied up with the question of who&nbsp;<em>should<\/em>&nbsp;get vaccinated is the more fundamental concern of who&nbsp;<em>can<\/em>. For shared decision making and individual choice to be meaningful, Levy says, vaccines should still remain accessible to patients in the absence of universal recommendations. \u201cThe appropriate solution is not mandates,\u201d he adds, \u201cbut availability.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Story by&nbsp;Shreyas Teegala and Simar Baja Experts say those patients at the highest risk of developing severe illness should get vaccinated.\u00a9&nbsp;Andriy Onufriyenko, Moment via Getty Images Since the first Covid-19 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":12641,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[669,445,1265,1266,607],"tags":[],"class_list":["post-12596","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-adenovirus-vector-vaccines","category-policies-politics","category-rfk","category-robert-f-kenney","category-vaccine-news"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/12596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12596"}],"version-history":[{"count":2,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/12596\/revisions"}],"predecessor-version":[{"id":12642,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/12596\/revisions\/12642"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/12641"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}