{"id":1547,"date":"2021-08-07T21:06:33","date_gmt":"2021-08-07T21:06:33","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=1547"},"modified":"2021-08-07T21:06:33","modified_gmt":"2021-08-07T21:06:33","slug":"antibody-dependent-enhancement","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=1547","title":{"rendered":"Antibody-dependent enhancement"},"content":{"rendered":"\n<p style=\"font-size:22px\"><strong>Antibody-dependent enhancement<\/strong>\u00a0(<strong>ADE<\/strong>), sometimes less precisely called\u00a0<strong>immune enhancement<\/strong>\u00a0or\u00a0<strong>disease enhancement<\/strong>, is a phenomenon in which binding of a virus to suboptimal\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Antibody\">antibodies<\/a>\u00a0enhances its\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Viral_entry\">entry<\/a>\u00a0into\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Host_(biology)\">host<\/a><a href=\"https:\/\/en.wikipedia.org\/wiki\/Cell_(biology)\">cells<\/a>, followed by its\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Viral_replication\">replication<\/a>.<sup><a href=\"https:\/\/en.wikipedia.org\/wiki\/Antibody-dependent_enhancement#cite_note-Tirado_2003-1\">[1]<\/a><a href=\"https:\/\/en.wikipedia.org\/wiki\/Antibody-dependent_enhancement#cite_note-:36-2\">[2]<\/a><\/sup>\u00a0ADE may cause\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Enhanced_respiratory_disease\">enhanced respiratory disease<\/a>\u00a0and acute lung injury after respiratory virus infection (ERD) with symptoms of monocytic infiltration and an excess of eosinophils in respiratory tract.<sup><a href=\"https:\/\/en.wikipedia.org\/wiki\/Antibody-dependent_enhancement#cite_note-:21-3\">[3]<\/a><\/sup>\u00a0ADE along with type 2 T helper cell-dependent mechanisms may contribute to a development of the vaccine associated disease enhancement (VADE), which is not limited to\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/VAERD\">respiratory disease<\/a>.<sup><a href=\"https:\/\/en.wikipedia.org\/wiki\/Antibody-dependent_enhancement#cite_note-:21-3\">[3]<\/a><\/sup>\u00a0Some vaccine candidates that targeted coronaviruses, RSV virus and Dengue virus elicited VADE, and were terminated from further development or became approved for use only for patients who have had those viruses before.<\/p>\n\n\n\n<p class=\"has-large-font-size\">For More Information: <a href=\"https:\/\/en.wikipedia.org\/wiki\/Antibody-dependent_enhancement\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/en.wikipedia.org\/wiki\/Antibody-dependent_enhancement<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antibody-dependent enhancement\u00a0(ADE), sometimes less precisely called\u00a0immune enhancement\u00a0or\u00a0disease enhancement, is a phenomenon in which binding of a virus to suboptimal\u00a0antibodies\u00a0enhances its\u00a0entry\u00a0into\u00a0hostcells, followed by its\u00a0replication.[1][2]\u00a0ADE may cause\u00a0enhanced respiratory disease\u00a0and acute lung injury [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1548,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,836,375,964,607],"tags":[],"class_list":["post-1547","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antibody","category-immune-system","category-news-of-the-day","category-t-cell","category-vaccine-news"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1547","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1547"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1547\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/1548"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1547"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1547"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}