{"id":1723,"date":"2021-08-10T20:17:51","date_gmt":"2021-08-10T20:17:51","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=1723"},"modified":"2021-08-10T20:17:51","modified_gmt":"2021-08-10T20:17:51","slug":"thrombocytopenia-following-pfizer-and-moderna-sars%e2%80%90cov%e2%80%902-vaccination","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=1723","title":{"rendered":"Thrombocytopenia following Pfizer and Moderna SARS\u2010CoV\u20102 vaccination"},"content":{"rendered":"\n

Authors: Eun\u2010Ju Lee<\/a>,\u00a01\u00a0<\/sup>Douglas B. Cines<\/a>,\u00a02\u00a0<\/sup>Terry Gernsheimer<\/a>,\u00a03\u00a0<\/sup>Craig Kessler<\/a>,\u00a04\u00a0<\/sup>Marc Michel<\/a>,\u00a05\u00a0<\/sup>Michael D. Tarantino<\/a>,\u00a06\u00a0<\/sup>John W. Semple<\/a>,\u00a07\u00a0<\/sup>Donald M. Arnold<\/a>,\u00a08\u00a0<\/sup>Bertrand Godeau<\/a>,\u00a05\u00a0<\/sup>Michele P. Lambert<\/a>,\u00a09 ,\u00a010\u00a0<\/sup>and\u00a0James B. Bussel<\/a>\u00a011<\/sup><\/p>\n\n\n\n

Cases of apparent secondary immune thrombocytopenia (ITP) after SARS\u2010CoV\u20102 vaccination with both the Pfizer and Moderna versions have been reported and reached public attention. Public alarm was heightened following the death of the first identified patient from an intracranial hemorrhage, which was reported on the Internet, then in USA Today 1 <\/a>and then in The New York Times. 2 <\/a>Described below, we have collected a series of cases of very low platelet counts occurring within 2\u2009weeks of vaccination in order to enhance our understanding of the possible relationship, if any, between SARS\u2010CoV\u20102 vaccination and development of ITP with implications for surveillance and management.<\/p>\n\n\n\n

Twenty case reports of patients with thrombocytopenia following vaccination, 17 without pre\u2010existing thrombocytopenia and 14 with reported bleeding symptoms prior to hospitalization were identified upon review of data available from the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA), agencies of the U.S. Department of Health and Human Services (HHS) Vaccine Adverse Events Reporting System (VAERS), published reports,\u00a03\u00a0<\/a>,\u00a04\u00a0<\/a>and via direct communication with patients and treating providers. These cases were investigated as suspicious for new onset, post\u2010vaccination secondary ITP; we could not exclude exacerbation of clinically undetected ITP. Search terms relating to \u201cdecreased platelet count\u201d, \u201cimmune thrombocytopenia\u201d, \u201chemorrhage\u201d, \u201cpetechiae\u201d, and \u201ccontusion\u201d were utilized to identify cases reported in VAERS.<\/p>\n\n\n\n

The reports describing 19 of 20 patients included age (range 22\u201373\u2009years old; median 41\u2009years) and gender (11 females and 8 males). Nine received the Pfizer vaccine and 11 received the Moderna vaccine. All 20 patients were hospitalized and most patients presented with petechiae, bruising or mucosal bleeding (gingival, vaginal, epistaxis) with onset of symptoms between 1\u201323\u2009days (median 5\u2009days) post vaccination. Platelet counts at presentation were available for all 20 cases with the majority being at or below 10 \u00d7\u2009109<\/sup>\/L (range 1\u201336 \u00d7\u2009109<\/sup>\/L; median 2 \u00d7\u2009109<\/sup>\/L).<\/p>\n\n\n\n

For More Information: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8014568\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Eun\u2010Ju Lee,\u00a01\u00a0Douglas B. Cines,\u00a02\u00a0Terry Gernsheimer,\u00a03\u00a0Craig Kessler,\u00a04\u00a0Marc Michel,\u00a05\u00a0Michael D. Tarantino,\u00a06\u00a0John W. Semple,\u00a07\u00a0Donald M. Arnold,\u00a08\u00a0Bertrand Godeau,\u00a05\u00a0Michele P. Lambert,\u00a09 ,\u00a010\u00a0and\u00a0James B. Bussel\u00a011 Cases of apparent secondary immune thrombocytopenia (ITP) after SARS\u2010CoV\u20102 vaccination […]<\/p>\n","protected":false},"author":2,"featured_media":1724,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[978,718,90,761,109,210,939,607],"tags":[],"class_list":["post-1723","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-adverse-event-reporting","category-blood-platelets","category-clots-bleeds","category-concerns","category-deep-vein-thrombosis","category-hemorrhage","category-safety-studies","category-vaccine-news"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1723","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1723"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1723\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/1724"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1723"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1723"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1723"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}