{"id":1939,"date":"2021-08-12T19:08:53","date_gmt":"2021-08-12T19:08:53","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=1939"},"modified":"2021-08-12T19:08:53","modified_gmt":"2021-08-12T19:08:53","slug":"hydroxychloroquine-and-azithromycin-as-a-treatment-of-covid-19-results-of-an-open-label-non-randomized-clinical-trial","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=1939","title":{"rendered":"Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial"},"content":{"rendered":"\n

Authors: Philippe Gautret<\/a>\u00a01<\/a><\/sup>,\u00a0Jean-Christophe Lagier<\/a>\u00a02<\/a><\/sup>,\u00a0Philippe Parola<\/a>\u00a01<\/a><\/sup>,\u00a0Van Thuan Hoang<\/a>\u00a03<\/a><\/sup>,\u00a0Line Meddeb<\/a>\u00a04<\/a><\/sup>,\u00a0Morgane Mailhe<\/a>\u00a04<\/a><\/sup>,\u00a0Barbara Doudier<\/a>\u00a04<\/a><\/sup>,\u00a0Johan Courjon<\/a>\u00a05<\/a><\/sup>,\u00a0Val\u00e9rie Giordanengo<\/a>\u00a06<\/a><\/sup>,\u00a0Vera Esteves Vieira<\/a>\u00a04<\/a><\/sup>,\u00a0Herv\u00e9 Tissot Dupont<\/a>\u00a02<\/a><\/sup>,\u00a0St\u00e9phane Honor\u00e9<\/a>\u00a07<\/a><\/sup>,\u00a0Philippe Colson<\/a>\u00a02<\/a><\/sup>,\u00a0Eric Chabri\u00e8re<\/a>\u00a02<\/a><\/sup>,\u00a0Bernard La Scola<\/a>\u00a02<\/a><\/sup>,\u00a0Jean-Marc Rolain<\/a>\u00a02<\/a><\/sup>,\u00a0Philippe Brouqui<\/a>\u00a02<\/a><\/sup>,\u00a0Didier Raoult<\/a>\u00a08<\/a><\/sup><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background: <\/strong>Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the effect of hydroxychloroquine on respiratory viral loads.<\/p>\n\n\n\n

Patients and methods: <\/strong>French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th<\/sup>, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.<\/p>\n\n\n\n

Results: <\/strong>Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported in the litterature for untreated patients. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.<\/p>\n\n\n\n

Conclusion:\u00a0<\/strong>Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction\/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.<\/p>\n\n\n\n

For More Information: https:\/\/pubmed<\/a>.ncbi.nlm.nih.gov\/32205204\/<\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Philippe Gautret\u00a01,\u00a0Jean-Christophe Lagier\u00a02,\u00a0Philippe Parola\u00a01,\u00a0Van Thuan Hoang\u00a03,\u00a0Line Meddeb\u00a04,\u00a0Morgane Mailhe\u00a04,\u00a0Barbara Doudier\u00a04,\u00a0Johan Courjon\u00a05,\u00a0Val\u00e9rie Giordanengo\u00a06,\u00a0Vera Esteves Vieira\u00a04,\u00a0Herv\u00e9 Tissot Dupont\u00a02,\u00a0St\u00e9phane Honor\u00e9\u00a07,\u00a0Philippe Colson\u00a02,\u00a0Eric Chabri\u00e8re\u00a02,\u00a0Bernard La Scola\u00a02,\u00a0Jean-Marc Rolain\u00a02,\u00a0Philippe Brouqui\u00a02,\u00a0Didier Raoult\u00a08 Abstract Background: Chloroquine and hydroxychloroquine have been […]<\/p>\n","protected":false},"author":2,"featured_media":1940,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[101,829,592],"tags":[],"class_list":["post-1939","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","category-hydroxychloroquine","category-treatments"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1939","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1939"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1939\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/1940"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1939"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}