{"id":1971,"date":"2021-08-12T20:16:30","date_gmt":"2021-08-12T20:16:30","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=1971"},"modified":"2021-08-12T20:16:30","modified_gmt":"2021-08-12T20:16:30","slug":"a-five-day-course-of-ivermectin-for-the-treatment-of-covid-19-may-reduce-the-duration-of-illness","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=1971","title":{"rendered":"A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness"},"content":{"rendered":"\n

Authors: Sabeena Ahmed<\/a>\u00a01<\/a><\/sup>,\u00a0Mohammad Mahbubul Karim<\/a>\u00a01<\/a><\/sup>,\u00a0Allen G Ross<\/a>\u00a01<\/a><\/sup>,\u00a0Mohammad Sharif Hossain<\/a>\u00a01<\/a><\/sup>,\u00a0John D Clemens<\/a>\u00a01<\/a><\/sup>,\u00a0Mariya Kibtiya Sumiya<\/a>\u00a01<\/a><\/sup>,\u00a0Ching Swe Phru<\/a>\u00a01<\/a><\/sup>,\u00a0Mustafizur Rahman<\/a>\u00a01<\/a><\/sup>,\u00a0Khalequ Zaman<\/a>\u00a01<\/a><\/sup>,\u00a0Jyoti Somani<\/a>\u00a02<\/a><\/sup>,\u00a0Rubina Yasmin<\/a>\u00a03<\/a><\/sup>,\u00a0Mohammad Abul Hasnat<\/a>\u00a04<\/a><\/sup>,\u00a0Ahmedul Kabir<\/a>\u00a05<\/a><\/sup>,\u00a0Asma Binte Aziz<\/a>\u00a01<\/a><\/sup>,\u00a0Wasif Ali Khan<\/a>\u00a06<\/a><\/sup><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. A randomized, double-blind, placebo-controlled trial was conducted to determine the rapidity of viral clearance and safety of ivermectin among adult SARS-CoV-2 patients. The trial included 72 hospitalized patients in Dhaka, Bangladesh, who were assigned to one of three groups: oral ivermectin alone (12 mg once daily for 5 days), oral ivermectin in combination with doxycycline (12 mg ivermectin single dose and 200 mg doxycycline on day 1, followed by 100 mg every 12 h for the next 4 days), and a placebo control group. Clinical symptoms of fever, cough, and sore throat were comparable among the three groups. Virologic clearance was earlier in the 5-day ivermectin treatment arm when compared to the placebo group (9.7 days vs 12.7 days; p = 0.02), but this was not the case for the ivermectin + doxycycline arm (11.5 days; p = 0.27). There were no severe adverse drug events recorded in the study. A 5-day course of ivermectin was found to be safe and effective in treating adult patients with mild COVID-19. Larger trials will be needed to confirm these preliminary findings.<\/p>\n\n\n\n

For More Information: https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Sabeena Ahmed\u00a01,\u00a0Mohammad Mahbubul Karim\u00a01,\u00a0Allen G Ross\u00a01,\u00a0Mohammad Sharif Hossain\u00a01,\u00a0John D Clemens\u00a01,\u00a0Mariya Kibtiya Sumiya\u00a01,\u00a0Ching Swe Phru\u00a01,\u00a0Mustafizur Rahman\u00a01,\u00a0Khalequ Zaman\u00a01,\u00a0Jyoti Somani\u00a02,\u00a0Rubina Yasmin\u00a03,\u00a0Mohammad Abul Hasnat\u00a04,\u00a0Ahmedul Kabir\u00a05,\u00a0Asma Binte Aziz\u00a01,\u00a0Wasif Ali Khan\u00a06 Abstract Ivermectin, a US […]<\/p>\n","protected":false},"author":2,"featured_media":1973,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[89,101,848,939,592],"tags":[],"class_list":["post-1971","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-trials","category-covid-19","category-ivermectin","category-safety-studies","category-treatments"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1971","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1971"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/1971\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/1973"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1971"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1971"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1971"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}