{"id":2011,"date":"2021-08-13T14:16:15","date_gmt":"2021-08-13T14:16:15","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2011"},"modified":"2021-08-13T14:16:15","modified_gmt":"2021-08-13T14:16:15","slug":"performance-of-an-antigen-based-test-for-asymptomatic-and-symptomatic-sars-cov-2-testing-at-two-university-campuses","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2011","title":{"rendered":"Performance of an Antigen-Based Test for Asymptomatic and Symptomatic SARS-CoV-2 Testing at Two University Campuses"},"content":{"rendered":"\n<p>Authors: Ian W. Pray, PhD<sup>1,2,3,<\/sup>*; Laura Ford, PhD<sup>1,2,<\/sup>*; Devlin Cole, MD<sup>3,4<\/sup>; Christine Lee, PhD<sup>1,5<\/sup>; John Paul Bigouette, PhD<sup>1,2<\/sup>; Glen R. Abedi, MPH<sup>1<\/sup>; Dena Bushman, MSN, MPH<sup>1,2<\/sup>; Miranda J. Delahoy, PhD<sup>1,2<\/sup>; Dustin Currie, PhD<sup>1,2<\/sup>; Blake Cherney, MS<sup>1<\/sup>; Marie Kirby, PhD<sup>1<\/sup>; Geroncio Fajardo, MD<sup>1<\/sup>; Motria Caudill, PhD<sup>1,6<\/sup>; Kimberly Langolf, MS<sup>7<\/sup>; Juliana Kahrs, MS<sup>7<\/sup>; Patrick Kelly, MD<sup>4,8<\/sup>; Collin Pitts, MD<sup>4,8<\/sup>; Ailam Lim, PhD<sup>9<\/sup>; Nicole Aulik, PhD<sup>9<\/sup>; Azaibi Tamin, PhD<sup>1<\/sup>; Jennifer L. Harcourt, PhD<sup>1<\/sup>; Krista Queen, PhD<sup>1<\/sup>; Jing Zhang, PhD<sup>1<\/sup>; Brett Whitaker, PhD<sup>1<\/sup>; Hannah Browne<sup>1<\/sup>; Magdalena Medrzycki, PhD<sup>1<\/sup>; Patricia Shewmaker, PhD<sup>1<\/sup>; Jennifer Folster, PhD<sup>1<\/sup>; Bettina Bankamp, PhD<sup>1<\/sup>; Michael D. Bowen, PhD<sup>1<\/sup>; Natalie J. Thornburg, PhD<sup>1<\/sup>; Kimberly Goffard, MBA<sup>10<\/sup>; Brandi Limbago, PhD<sup>1<\/sup>; Allen Bateman, PhD<sup>7,11<\/sup>; Jacqueline E. Tate, PhD<sup>1<\/sup>; Douglas Gieryn<sup>10<\/sup>; Hannah L. Kirking, MD<sup>1<\/sup>; Ryan Westergaard, MD, PhD<sup>3,4<\/sup>; Marie Killerby, VetMB<sup>1<\/sup>; CDC COVID-19 Surge Laboratory Group (<a href=\"https:\/\/www.cdc.gov\/mmwr\/volumes\/69\/wr\/mm695152a3.htm#contribAff\">View author affiliations<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Summary<\/strong><\/h3>\n\n\n\n<p style=\"font-size:24px\"><strong>What is already known about this topic?<\/strong><\/p>\n\n\n\n<p style=\"font-size:24px\">Antigen tests for SARS-CoV-2 are inexpensive and can return results within 15 minutes, but test performance data in asymptomatic and symptomatic persons are limited.<\/p>\n\n\n\n<p style=\"font-size:24px\"><strong>What is added by this report?<\/strong><\/p>\n\n\n\n<p style=\"font-size:24px\">Compared with real-time reverse transcription\u2013polymerase chain reaction (RT-PCR) testing, the Sofia antigen test had a sensitivity of 80.0% and specificity of 98.9% among symptomatic persons; accuracy was lower (sensitivity 41.2% and specificity 98.4%) when used for screening of asymptomatic persons.<\/p>\n\n\n\n<p style=\"font-size:24px\"><strong>What are the implications for public health practice?<\/strong><\/p>\n\n\n\n<p style=\"font-size:24px\">To account for reduced antigen test accuracy, confirmatory testing with a nucleic acid amplification test (e.g., RT-PCR) should be considered after negative antigen test results in symptomatic persons and positive antigen test results in asymptomatic persons.<\/p>\n\n\n\n<p class=\"has-large-font-size\">For More Information: <a href=\"https:\/\/www.cdc.gov\/mmwr\/volumes\/69\/wr\/mm695152a3.htm\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.cdc.gov\/mmwr\/volumes\/69\/wr\/mm695152a3.htm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors: Ian W. Pray, PhD1,2,3,*; Laura Ford, PhD1,2,*; Devlin Cole, MD3,4; Christine Lee, PhD1,5; John Paul Bigouette, PhD1,2; Glen R. Abedi, MPH1; Dena Bushman, MSN, MPH1,2; Miranda J. Delahoy, PhD1,2; [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2012,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,683,119,477],"tags":[],"class_list":["post-2011","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antigen","category-antigen-test","category-diagnostics-covid-19","category-qrt-pcr"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2011"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2011\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2012"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}