{"id":2156,"date":"2021-08-15T15:52:21","date_gmt":"2021-08-15T15:52:21","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2156"},"modified":"2021-08-15T15:52:21","modified_gmt":"2021-08-15T15:52:21","slug":"risk-factors-for-severe-and-critically-ill-covid-19-patients-a-review","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2156","title":{"rendered":"Risk factors for severe and critically ill COVID-19 patients: A review"},"content":{"rendered":"\n

Authors: Ya-Dong Gao<\/a>\u00a01<\/a><\/sup>,\u00a0Mei Ding<\/a>\u00a01<\/a>\u00a02<\/a><\/sup>,\u00a0Xiang Dong<\/a>\u00a01<\/a><\/sup>,\u00a0Jin-Jin Zhang<\/a>\u00a01<\/a><\/sup>,\u00a0Ahmet Kursat Azkur<\/a>\u00a03<\/a><\/sup>,\u00a0Dilek Azkur<\/a>\u00a04<\/a><\/sup>,\u00a0Hui Gan<\/a>\u00a01<\/a><\/sup>,\u00a0Yuan-Li Sun<\/a>\u00a01<\/a><\/sup>,\u00a0Wei Fu<\/a>\u00a01<\/a><\/sup>,\u00a0Wei Li<\/a>\u00a01<\/a><\/sup>,\u00a0Hui-Ling Liang<\/a>\u00a01<\/a><\/sup>,\u00a0Yi-Yuan Cao<\/a>\u00a05<\/a><\/sup>,\u00a0Qi Yan<\/a>\u00a06<\/a><\/sup>,\u00a0Can Cao<\/a>\u00a01<\/a><\/sup>,\u00a0Hong-Yu Gao<\/a>\u00a06<\/a><\/sup>,\u00a0Marie-Charlotte Br\u00fcggen<\/a>\u00a07<\/a>\u00a08<\/a>\u00a09<\/a><\/sup>,\u00a0Willem van de Veen<\/a>\u00a02<\/a><\/sup>,\u00a0Milena Sokolowska<\/a>\u00a02<\/a><\/sup>,\u00a0M\u00fcbeccel Akdis<\/a>\u00a02<\/a><\/sup>,\u00a0Cezmi A Akdis<\/a>\u00a02<\/a><\/sup><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global social and economic impact, and high numbers of deaths. Many risk factors have been identified in the progression of COVID-19 into a severe and critical stage, including old age, male gender, underlying comorbidities such as hypertension, diabetes, obesity, chronic lung diseases, heart, liver and kidney diseases, tumors, clinically apparent immunodeficiencies, local immunodeficiencies, such as early type I interferon secretion capacity, and pregnancy. Possible complications include acute kidney injury, coagulation disorders, thromboembolism. The development of lymphopenia and eosinopenia are laboratory indicators of COVID-19. Laboratory parameters to monitor disease progression include lactate dehydrogenase, procalcitonin, high-sensitivity C-reactive protein, proinflammatory cytokines such as interleukin (IL)-6, IL-1\u03b2, Krebs von den Lungen-6 (KL-6), and ferritin. The development of a cytokine storm and extensive chest computed tomography imaging patterns are indicators of a severe disease. In addition, socioeconomic status, diet, lifestyle, geographical differences, ethnicity, exposed viral load, day of initiation of treatment, and quality of health care have been reported to influence individual outcomes. In this review, we highlight the scientific evidence on the risk factors of severity of COVID-19.<\/p>\n\n\n\n

For More Information: https:\/\/pubmed.ncbi.nlm.nih.gov\/33185910\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Ya-Dong Gao\u00a01,\u00a0Mei Ding\u00a01\u00a02,\u00a0Xiang Dong\u00a01,\u00a0Jin-Jin Zhang\u00a01,\u00a0Ahmet Kursat Azkur\u00a03,\u00a0Dilek Azkur\u00a04,\u00a0Hui Gan\u00a01,\u00a0Yuan-Li Sun\u00a01,\u00a0Wei Fu\u00a01,\u00a0Wei Li\u00a01,\u00a0Hui-Ling Liang\u00a01,\u00a0Yi-Yuan Cao\u00a05,\u00a0Qi Yan\u00a06,\u00a0Can Cao\u00a01,\u00a0Hong-Yu Gao\u00a06,\u00a0Marie-Charlotte Br\u00fcggen\u00a07\u00a08\u00a09,\u00a0Willem van de Veen\u00a02,\u00a0Milena Sokolowska\u00a02,\u00a0M\u00fcbeccel Akdis\u00a02,\u00a0Cezmi A Akdis\u00a02 Abstract The pandemic of […]<\/p>\n","protected":false},"author":2,"featured_media":2157,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[101,503],"tags":[],"class_list":["post-2156","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","category-risk-factors"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2156"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2156\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2157"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2156"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2156"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}