{"id":2305,"date":"2021-08-17T17:47:29","date_gmt":"2021-08-17T17:47:29","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2305"},"modified":"2021-08-17T17:47:29","modified_gmt":"2021-08-17T17:47:29","slug":"uniprotkb-p59636-orf9b_sars","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2305","title":{"rendered":"UniProtKB &#8211; P59636 (ORF9B_SARS)"},"content":{"rendered":"\n<p class=\"has-large-font-size\"><strong>Protein<\/strong>: ORF9b protein database<\/p>\n\n\n\n<p style=\"font-size:24px\">Gene: 9b<\/p>\n\n\n\n<p>Organism <em>Severe acute respiratory syndrome coronavirus (SARS-CoV)<\/em> Status <a href=\"https:\/\/www.uniprot.org\/manual\/entry_status\">Reviewed<\/a>-Annotation score:-Experimental evidence at protein level<sup>i<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Function<sup>i<\/sup><\/h2>\n\n\n\n<p style=\"font-size:24px\">Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1\/DNM1L.1 Publication<\/p>\n\n\n\n<h4 class=\"has-medium-font-size wp-block-heading\">Miscellaneous<\/h4>\n\n\n\n<p style=\"font-size:24px\">The gene encoding this protein is included within the N gene (alternative ORF).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">GO &#8211; Molecular function<sup>i<\/sup><\/h4>\n\n\n\n<ul class=\"has-medium-font-size wp-block-list\"><li><a href=\"https:\/\/www.ebi.ac.uk\/QuickGO\/term\/GO:0042802\">identical protein binding<\/a>\u00a0Source: IntAct <\/li><li><a href=\"https:\/\/www.ebi.ac.uk\/QuickGO\/annotations?geneProductId=P59636\">Complete GO annotation on QuickGO &#8230;<\/a><\/li><\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">GO &#8211; Biological process<sup>i<\/sup><\/h4>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.ebi.ac.uk\/QuickGO\/term\/GO:0039545\">suppression by virus of host MAVS activity<\/a>\u00a0Source: UniProtKB<\/li><li><a href=\"https:\/\/www.ebi.ac.uk\/QuickGO\/annotations?geneProductId=P59636\">Complete GO annotation on QuickGO &#8230;<\/a><\/li><\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Keywords<sup>i<\/sup><\/h4>\n\n\n\n<figure class=\"wp-block-table is-style-regular\"><table><tbody><tr><td>Biological process<\/td><td><a href=\"https:\/\/www.uniprot.org\/keywords\/KW-0945\">Host-virus interaction<\/a>,&nbsp;<a href=\"https:\/\/www.uniprot.org\/keywords\/KW-1090\">Inhibition of host innate immune response by virus<\/a>,&nbsp;<a href=\"https:\/\/www.uniprot.org\/keywords\/KW-1097\">Inhibition of host MAVS by virus<\/a>,&nbsp;<a href=\"https:\/\/www.uniprot.org\/keywords\/KW-1113\">Inhibition of host RLR pathway by virus<\/a>,&nbsp;<a href=\"https:\/\/www.uniprot.org\/keywords\/KW-0899\">Viral immunoevasion<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"has-large-font-size\">For In-depth Information of ORF-9b Protein: <a href=\"https:\/\/www.uniprot.org\/uniprot\/P59636\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.uniprot.org\/uniprot\/P59636<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Protein: ORF9b protein database Gene: 9b Organism Severe acute respiratory syndrome coronavirus (SARS-CoV) Status Reviewed-Annotation score:-Experimental evidence at protein leveli Functioni Plays a role in the inhibition of host innate [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2306,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[323,324,392],"tags":[],"class_list":["post-2305","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mitochondria","category-mitochondrial-adapters-mavs","category-orf-9b"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2305"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2305\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2306"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2305"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2305"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}