{"id":2338,"date":"2021-08-18T15:16:10","date_gmt":"2021-08-18T15:16:10","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2338"},"modified":"2021-08-18T15:16:10","modified_gmt":"2021-08-18T15:16:10","slug":"cardiac-troponin-i-and-covid-19-a-prognostic-tool-for-in-hospital-mortality","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2338","title":{"rendered":"Cardiac Troponin-I and COVID-19: A Prognostic Tool for In-Hospital Mortality"},"content":{"rendered":"\n

Authors: Baher Al Abbasi<\/a>\u00a01<\/a><\/sup>,\u00a0Pedro Torres<\/a>\u00a01<\/a><\/sup>,\u00a0Fergie Ramos-Tuarez<\/a>\u00a02<\/a><\/sup>,\u00a0Nakeya Dewaswala<\/a>\u00a01<\/a><\/sup>,\u00a0Ahmed Abdallah<\/a>\u00a01<\/a><\/sup>,\u00a0Kai Chen<\/a>\u00a01<\/a><\/sup>,\u00a0Mohamed Abdul Qader<\/a>\u00a01<\/a><\/sup>,\u00a0Riya Job<\/a>\u00a01<\/a><\/sup>,\u00a0Samar Aboulenain<\/a>\u00a01<\/a><\/sup>,\u00a0Karolina Dziadkowiec<\/a>\u00a01<\/a><\/sup>,\u00a0Huzefa Bhopalwala<\/a>\u00a03<\/a><\/sup>,\u00a0Jesus E Pino<\/a>\u00a02<\/a><\/sup>,\u00a0Robert D Chait<\/a>\u00a02<\/a><\/sup><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background: <\/strong>The number of fatalities due to coronavirus disease 2019 (COVID-19) is escalating with more than 800,000 deaths globally. The scientific community remains in urgent need of prognostic tools to determine the probability of survival in patients with COVID-19 and to determine the need for hospitalization.<\/p>\n\n\n\n

Methods: <\/strong>This is a retrospective cohort study of patients with a diagnosis of COVID-19 admitted to a tertiary center between March 2020 and July 2020. Patients age 18 years and older were stratified into two groups based on their troponin-I level in the first 24 h of admission (groups: elevated vs. normal). The aim of the study is to explore the utility of cardiac troponin-I level for early prognostication of patients with COVID-19.<\/p>\n\n\n\n

Results: <\/strong>This cohort of 257 patients included 122\/257 (47%) women with a mean age of 63 \u00b1 17 years. Patients with an elevated troponin-I level were more likely to be older (77 \u00b1 13 vs. 58 \u00b1 16 years, P < 0.0001), have a history of hypertension (P < 0.0001), diabetes mellitus (P = 0.0019), atrial fibrillation or flutter (P = 0.0009), coronary artery disease (P < 0.0001), and chronic heart failure (P = 0.0011). Patients with an elevated troponin-I level in the first 24 h of admission were more likely to have higher in-hospital mortality (52% vs. 10%, P < 0.0001). Troponin-I level in the first 24 h of admission had a negative predictive value of 89.7% and a positive predictive value of 51.9% for all-cause in-hospital mortality.<\/p>\n\n\n\n

Conclusions:\u00a0<\/strong>Troponin-I elevation is commonly seen in patients with COVID-19 and is significantly associated with fatal outcomes. However, a normal troponin-I level in the first 24 h of admission had a high negative predictive value for all-cause in-hospital mortality, thereby predicting favorable survival at the time of discharge.<\/p>\n\n\n\n

For More Information: https:\/\/pubmed.ncbi.nlm.nih.gov\/33224386\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Baher Al Abbasi\u00a01,\u00a0Pedro Torres\u00a01,\u00a0Fergie Ramos-Tuarez\u00a02,\u00a0Nakeya Dewaswala\u00a01,\u00a0Ahmed Abdallah\u00a01,\u00a0Kai Chen\u00a01,\u00a0Mohamed Abdul Qader\u00a01,\u00a0Riya Job\u00a01,\u00a0Samar Aboulenain\u00a01,\u00a0Karolina Dziadkowiec\u00a01,\u00a0Huzefa Bhopalwala\u00a03,\u00a0Jesus E Pino\u00a02,\u00a0Robert D Chait\u00a02 Abstract Background: The number of fatalities due to coronavirus disease 2019 (COVID-19) […]<\/p>\n","protected":false},"author":2,"featured_media":2339,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[738,332,360],"tags":[],"class_list":["post-2338","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiac-troponin","category-mortality","category-negative-outcomes"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2338"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2338\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2339"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}