{"id":2347,"date":"2021-08-18T15:39:21","date_gmt":"2021-08-18T15:39:21","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2347"},"modified":"2021-08-18T15:39:21","modified_gmt":"2021-08-18T15:39:21","slug":"high-sensitivity-troponin-and-covid-19-outcomes","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2347","title":{"rendered":"High sensitivity troponin and COVID-19 outcomes"},"content":{"rendered":"\n

Authors: Nikolaos Papageorgiou<\/a>,a,b<\/sup>Catrin Sohrabi<\/a>,a<\/sup>David Prieto Merino<\/a>,c,d<\/sup>Angelos Tyrlis<\/a>,a<\/sup>Abed Elfattah Atieh<\/a>,a<\/sup>Bunny Saberwal<\/a>,a<\/sup>Wei-Yao Lim<\/a>,a<\/sup>Antonio Creta<\/a>,a<\/sup>Mohammed Khanji<\/a>,a<\/sup>Reni Rusinova<\/a>,a<\/sup>Bashistraj Chooneea<\/a>,a<\/sup>Raj Khiani<\/a>,d,e<\/sup>Nadeev Wijesuriya<\/a>,e,f<\/sup>Anna Chow<\/a>,e,f<\/sup>Haroun Butt<\/a>,e,f<\/sup>Stefan Browne<\/a>,e,f<\/sup>Nikhil Joshi<\/a>,e,f<\/sup>Jamie Kay<\/a>,e,f<\/sup>Syed Ahsan<\/a>,a<\/sup>\u00a0and\u00a0Rui Providencia<\/a>a,g<\/sup><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

Recent reports have demonstrated high troponin levels in patients affected with COVID-19. In the present study, we aimed to determine the association between admission and peak troponin levels and COVID-19 outcomes.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

This was an observational multi-ethnic multi-centre study in a UK cohort of 434 patients admitted and diagnosed COVID-19 positive, across six hospitals in London, UK during the second half of March 2020.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

Myocardial injury, defined as positive troponin during admission was observed in 288 (66.4%) patients. Age (OR: 1.68 [1.49\u20131.88], p<\/em>\u2009<\u2009.001), hypertension (OR: 1.81 [1.10\u20132.99], p<\/em>\u2009=\u2009.020) and moderate chronic kidney disease (OR: 9.12 [95% CI: 4.24\u201319.64], p<\/em>\u2009<\u2009.001) independently predicted myocardial injury. After adjustment, patients with positive peak troponin were more likely to need non-invasive and mechanical ventilation (OR: 2.40 [95% CI: 1.27\u20134.56], p<\/em>\u2009=\u2009.007, and OR: 6.81 [95% CI: 3.40\u201313.62], p<\/em>\u2009<\u2009.001, respectively) and urgent renal replacement therapy (OR: 4.14 [95% CI: 1.34\u201312.78], p<\/em>\u2009=\u2009.013). With regards to events, and after adjustment, positive peak troponin levels were independently associated with acute kidney injury (OR: 6.76 [95% CI: 3.40\u201313.47], p<\/em>\u2009<\u2009.001), venous thromboembolism (OR: 11.99 [95% CI: 3.20\u201344.88], p<\/em>\u2009<\u2009.001), development of atrial fibrillation (OR: 10.66 [95% CI: 1.33\u201385.32], p<\/em>\u2009=\u2009.026) and death during admission (OR: 2.40 [95% CI: 1.34\u20134.29], p<\/em>\u2009=\u2009.003). Similar associations were observed for admission troponin. In addition, median length of stay in days was shorter for patients with negative troponin levels: 8 (5\u201313) negative, 14 (7\u201323) low-positive levels and 16 (10\u201323) high-positive (p<\/em>\u2009<\u2009.001).<\/p>\n\n\n\n

Conclusions<\/h3>\n\n\n\n

Admission and peak troponin appear to be predictors for cardiovascular and non-cardiovascular events and outcomes in COVID-19 patients, and their utilization may have an impact on patient management.<\/p>\n\n\n\n

For More Information: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7970632\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Nikolaos Papageorgiou,a,bCatrin Sohrabi,aDavid Prieto Merino,c,dAngelos Tyrlis,aAbed Elfattah Atieh,aBunny Saberwal,aWei-Yao Lim,aAntonio Creta,aMohammed Khanji,aReni Rusinova,aBashistraj Chooneea,aRaj Khiani,d,eNadeev Wijesuriya,e,fAnna Chow,e,fHaroun Butt,e,fStefan Browne,e,fNikhil Joshi,e,fJamie Kay,e,fSyed Ahsan,a\u00a0and\u00a0Rui Providenciaa,g Abstract Background Recent reports have demonstrated […]<\/p>\n","protected":false},"author":2,"featured_media":2348,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[701,738,109,269,349,360],"tags":[],"class_list":["post-2347","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-atrial-fibrillation","category-cardiac-troponin","category-deep-vein-thrombosis","category-kidney","category-myocardial-infarct","category-negative-outcomes"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2347"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2347\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2348"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2347"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2347"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}