{"id":2353,"date":"2021-08-18T15:54:34","date_gmt":"2021-08-18T15:54:34","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2353"},"modified":"2021-08-18T15:54:34","modified_gmt":"2021-08-18T15:54:34","slug":"elevated-level-of-c%e2%80%90reactive-protein-may-be-an-early-marker-to-predict-risk-for-severity-of-covid%e2%80%9019","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2353","title":{"rendered":"Elevated level of C\u2010reactive protein may be an early marker to predict risk for severity of COVID\u201019"},"content":{"rendered":"\n

Authors: Nurshad Ali<\/a>\u00a01<\/sup><\/p>\n\n\n\n

The outbreak of coronavirus disease\u20102019 (COVID\u201019) is an emerging global health threat. The healthcare workers are facing challenges in reducing the severity and mortality of COVID\u201019 across the world. Severe patients with COVID\u201019 are generally treated in the intensive care unit, while mild or non\u2010severe patients treated in the usual isolation ward of the hospital. However, there is an emerging challenge that a small subset of mild or non\u2010severe COVID\u201019 patients develops into a severe disease course. Therefore, it is important to early identify and give the treatment of this subset of patients to reduce the disease severity and improve the outcomes of COVID\u201019. Clinical studies demonstrated that altered levels of some blood markers might be linked with the degree of severity and mortality of patients with COVID\u201019.\u00a01\u00a0<\/a>,\u00a02\u00a0<\/a>,\u00a03\u00a0<\/a>,\u00a04\u00a0<\/a>,\u00a05\u00a0<\/a>Of these clinical parameter, serum C\u2010reactive protein (CRP) has been found as an important marker that changes significantly in severe patients with COVID\u201019.\u00a03\u00a0<\/a>CRP is a type of protein produced by the liver that serves as an early marker of infection and inflammation.\u00a06\u00a0<\/a>In blood, the normal concentration of CRP is less than 10\u2009mg\/L; however, it rises rapidly within 6 to 8\u2009hours and gives the highest peak in 48\u2009hours from the disease onset.\u00a07\u00a0<\/a>Its half\u2010life is about 19 hours\u00a08\u00a0<\/a>and its concentration decreases when the inflammatory stages end and the patient is healing. CRP preferably binds to phosphocholine expressed highly on the surface of damaged cells.\u00a09\u00a0<\/a>This binding makes active the classical complement pathway of the immune system and modulates the phagocytic activity to clear microbes and damaged cells from the organism.\u00a07\u00a0<\/a>When the inflammation or tissue damage is resolved, CRP concentration falls, making it a useful marker for monitoring disease severity.\u00a07<\/a><\/p>\n\n\n\n

The available studies that have determined serum concentration of CRP in patients with COVID\u201019 are presented in Table\u00a01<\/a>. A significant increase of CRP was found with levels on average 20 to 50\u2009mg\/L in patients with COVID\u201019.\u00a010\u00a0<\/a>,\u00a012\u00a0<\/a>,\u00a021\u00a0<\/a>Elevated levels of CRP were observed up to 86% in severe COVID\u201019 patients.\u00a010\u00a0<\/a>,\u00a011\u00a0<\/a>,\u00a013\u00a0<\/a>Patients with severe disease courses had a far elevated level of CRP than mild or non\u2010severe patients. For example, a study reported that patients with more severe symptoms had on average CRP concentration of 39.4\u2009mg\/L and patients with mild symptoms CRP concentration of 18.8\u2009mg\/L.\u00a012\u00a0<\/a>CRP was found at increased levels in the severe group at the initial stage than those in the mild group.\u00a01\u00a0<\/a>In another study, the mean concentration of CRP was significantly higher in severe patients (46\u2009mg\/L) than non\u2010severe patients (23\u2009mg\/L).\u00a021\u00a0<\/a>The patients who died from COVID\u201019 had about 10 fold higher levels of CRP than the recovered patients (median 100\u00a0vs 9.6\u2009mg\/L).\u00a016\u00a0<\/a>A recent study showed that about 7.7% of non\u2010severe COVID\u201019 patients were progressed to severe disease courses after hospitalization,\u00a03\u00a0<\/a>and compared to non\u2010severe cases, the aggravated patients had significantly higher concentrations of CRP (median 43.8\u00a0vs 12.1\u2009mg\/L). A significant association was observed between CRP concentrations and the aggravation of non\u2010severe patients with COVID\u201019 [1], and the authors proposed CRP as a suitable marker for anticipating the aggravation probability of non\u2010severe COVID\u201019 patients, with an optimal threshold value of 26.9\u2009mg\/L.\u00a03\u00a0<\/a>The authors also noted that the risk of developing severe events is increased by 5% for every one\u2010unit increase in CRP concentration in patients with COVID\u201019.<\/p>\n\n\n\n

For More Information: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7301027\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Nurshad Ali\u00a01 The outbreak of coronavirus disease\u20102019 (COVID\u201019) is an emerging global health threat. The healthcare workers are facing challenges in reducing the severity and mortality of COVID\u201019 across […]<\/p>\n","protected":false},"author":2,"featured_media":2354,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[732,252,286,333,360,524],"tags":[],"class_list":["post-2353","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-c-reactive-protein","category-inflammation","category-liver","category-mortality-morbidity","category-negative-outcomes","category-severity"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2353"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2353\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2354"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}