{"id":2401,"date":"2021-08-18T18:39:52","date_gmt":"2021-08-18T18:39:52","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2401"},"modified":"2021-08-18T18:39:52","modified_gmt":"2021-08-18T18:39:52","slug":"circulating-mitochondrial-dna-is-an-early-indicator-of-severe-illness-and-mortality-from-covid-19","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2401","title":{"rendered":"Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19"},"content":{"rendered":"\n

Authors: Davide Scozzi<\/a>,1<\/sup>Marlene Cano<\/a>,2<\/sup>Lina Ma<\/a>,2<\/sup>Dequan Zhou<\/a>,1<\/sup>Ji Hong Zhu<\/a>,1<\/sup>Jane A. O\u2019Halloran<\/a>,3<\/sup>Charles Goss<\/a>,4<\/sup>Adriana M. Rauseo<\/a>,3<\/sup>Zhiyi Liu<\/a>,1<\/sup>Sanjaya K. Sahu<\/a>,2<\/sup>Valentina Peritore<\/a>,5<\/sup>Monica Rocco<\/a>,6<\/sup>Alberto Ricci<\/a>,7<\/sup>Rachele Amodeo<\/a>,8<\/sup>Laura Aimati<\/a>,8<\/sup>Mohsen Ibrahim<\/a>,1,5<\/sup>Ramsey Hachem<\/a>,2<\/sup>Daniel Kreisel<\/a>,1<\/sup>Philip A. Mudd<\/a>,9<\/sup>Hrishikesh S. Kulkarni<\/a>,2,10<\/sup>\u00a0and\u00a0Andrew E. Gelman<\/a>1,11<\/sup><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

We measured circulating MT-DNA levels in prospectively collected, cell-free plasma samples from 97 subjects with COVID-19 at hospital presentation. Our primary outcome was mortality. Intensive care unit (ICU) admission, intubation, vasopressor, and renal replacement therapy requirements were secondary outcomes. Multivariate regression analysis determined whether MT-DNA levels were independent of other reported COVID-19 risk factors. Receiver operating characteristic and area under the curve assessments were used to compare MT-DNA levels with established and emerging inflammatory markers of COVID-19.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

Circulating MT-DNA levels were highly elevated in patients who eventually died or required ICU admission, intubation, vasopressor use, or renal replacement therapy. Multivariate regression revealed that high circulating MT-DNA was an independent risk factor for these outcomes after adjusting for age, sex, and comorbidities. We also found that circulating MT-DNA levels had a similar or superior area under the curve when compared against clinically established measures of inflammation and emerging markers currently of interest as investigational targets for COVID-19 therapy.<\/p>\n\n\n\n

Conclusion<\/h3>\n\n\n\n

These results show that high circulating MT-DNA levels are a potential early indicator for poor COVID-19 outcomes.<\/p>\n\n\n\n

For More Information: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7934921\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Davide Scozzi,1Marlene Cano,2Lina Ma,2Dequan Zhou,1Ji Hong Zhu,1Jane A. O\u2019Halloran,3Charles Goss,4Adriana M. Rauseo,3Zhiyi Liu,1Sanjaya K. Sahu,2Valentina Peritore,5Monica Rocco,6Alberto Ricci,7Rachele Amodeo,8Laura Aimati,8Mohsen Ibrahim,1,5Ramsey Hachem,2Daniel Kreisel,1Philip A. Mudd,9Hrishikesh S. Kulkarni,2,10\u00a0and\u00a0Andrew E. Gelman1,11 […]<\/p>\n","protected":false},"author":2,"featured_media":2402,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[252,323,333,338,503],"tags":[],"class_list":["post-2401","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-inflammation","category-mitochondria","category-mortality-morbidity","category-mt-dna","category-risk-factors"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2401"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2401\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2402"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}