{"id":2407,"date":"2021-08-18T18:57:41","date_gmt":"2021-08-18T18:57:41","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2407"},"modified":"2021-08-18T18:57:41","modified_gmt":"2021-08-18T18:57:41","slug":"blood-molecular-markers-associated-with-covid-19-immunopathology-and-multi-organ-damage","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2407","title":{"rendered":"Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage"},"content":{"rendered":"\n

Authors: Yan-Mei Chen<\/a>Yuanting Zheng<\/a>Ying Yu<\/a>Yunzhi Wang<\/a>Qingxia Huang<\/a>Feng Qian<\/a>Lei Sun<\/a>Zhi-Gang Song<\/a>Ziyin Chen<\/a>Jinwen Feng<\/a>Yanpeng An<\/a>Jingcheng Yang<\/a>Zhenqiang Su<\/a>Shanyue Sun<\/a>Fahui Dai<\/a>Qinsheng Chen<\/a>Qinwei Lu<\/a>Pengcheng Li<\/a>Yun Ling<\/a>Zhong Yang<\/a>Huiru Tang<\/a>Leming Shi<\/a>Li Jin<\/a>Edward C Holmes<\/a>Chen Ding<\/a>Tong-Yu Zhu<\/a>Yong-Zhen Zhang<\/a><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

COVID-19 is characterized by dysregulated immune responses, metabolic dysfunction and adverse effects on the function of multiple organs. To understand host responses to COVID-19 pathophysiology, we combined transcriptomics, proteomics, and metabolomics to identify molecular markers in peripheral blood and plasma samples of 66 COVID-19-infected patients experiencing a range of disease severities and 17 healthy controls. A large number of expressed genes, proteins, metabolites, and extracellular RNAs (exRNAs) exhibit strong associations with various clinical parameters. Multiple sets of tissue-specific proteins and exRNAs varied significantly in both mild and severe patients suggesting a potential impact on tissue function. Chronic activation of neutrophils, IFN-I signaling, and a high level of inflammatory cytokines were observed in patients with severe disease progression. In contrast, COVID-19-infected patients experiencing milder disease symptoms showed robust T-cell responses. Finally, we identified genes, proteins, and exRNAs as potential biomarkers that might assist in predicting the prognosis of SARS-CoV-2 infection. These data refine our understanding of the pathophysiology and clinical progress of COVID-19.<\/p>\n\n\n\n

Proteomics, metabolomics and RNAseq data map immune responses in COVID-19 patients with different disease severity, revealing molecular makers associated with disease progression and alterations of tissue-specific proteins.<\/p>\n\n\n\n