{"id":2518,"date":"2021-08-20T15:58:46","date_gmt":"2021-08-20T15:58:46","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2518"},"modified":"2021-08-20T15:58:46","modified_gmt":"2021-08-20T15:58:46","slug":"more-than-50-long-term-effects-of-covid-19-a-systematic-review-and-meta-analysis-2","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2518","title":{"rendered":"More than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis"},"content":{"rendered":"\n

Authors: L\u00f3pez-Le\u00f3n S<\/a>,\u00a0Wegman-Ostrosky T<\/a>,\u00a0Perelman C<\/a>,\u00a0Sepulveda R<\/a>,\u00a0Rebolledo PA<\/a>,\u00a0Cuapio A<\/a>,\u00a0Villapol S<\/a> Preprint from\u00a0SSRN,\u00a020 Jan 2021<\/p>\n\n\n\n

Abstract <\/h2>\n\n\n\n
\n\n\n\n

Background: COVID-19, caused by SARS-CoV-2, can involve sequelae that last weeks to months after initial recovery. The objective of this systematic review and meta-analysis is to identify studies assessing the long-term effects of COVID-19 and estimate the prevalence of each symptom, sign, or laboratory parameters of patients at a post-COVID-19 stage.<\/p>\n\n\n\n

Methods: In this systematic review and meta-analysis, LitCOVID (PubMed and Medline) and Embase were searched by two independent researchers. Studies published before 1st of January 2021 and with a minimum of 100 patients were included. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. Heterogeneity was assessed using the I2 statistics. PRISMA guidelines were followed.<\/p>\n\n\n\n

Findings: A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included. The follow-up time ranged from 15 to 110 days post-viral infection. The age of the study participants ranged between 17 and 87 years. It was estimated that 80% (95% CI 65-92) of the patients that were infected with SARS-CoV-2 developed one or more symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). In order to have a better understanding, there is a need for studies to stratify by sex, age, previous comorbidities, severity of COVID-19 (including asymptomatic), and duration of each symptom.<\/p>\n\n\n\n

Interpretation: From the clinical perspective, multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address after-COVID-19 care.<\/p>\n\n\n\n

Funding: National Institute for Neurological Disorders and Stroke (NINDS), and Houston Methodist Research Institute, Houston, TX.<\/p>\n\n\n\n

Declaration of Interests: SLL is an employee of Novartis Pharmaceutical Company; the statements presented in the paper do not necessarily represent the position of the company. The remaining authors have no competing interests to declare.<\/p>\n\n\n\n

For More Information: https:\/\/europepmc.org\/article\/PPR\/PPR280403<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: L\u00f3pez-Le\u00f3n S,\u00a0Wegman-Ostrosky T,\u00a0Perelman C,\u00a0Sepulveda R,\u00a0Rebolledo PA,\u00a0Cuapio A,\u00a0Villapol S Preprint from\u00a0SSRN,\u00a020 Jan 2021 Abstract  Background: COVID-19, caused by SARS-CoV-2, can involve sequelae that last weeks to months after initial recovery. […]<\/p>\n","protected":false},"author":2,"featured_media":2519,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[702,790,169,822,823,289,290,314,561],"tags":[],"class_list":["post-2518","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-attention-deficit","category-dysgeusia","category-fatigure","category-hair-loss","category-headache-symptoms-covid-19","category-long-haul-disease","category-long-term-effects","category-meta-analysis","category-symptoms-covid-19"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2518"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2518\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2519"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}