{"id":2582,"date":"2021-08-21T16:03:28","date_gmt":"2021-08-21T16:03:28","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2582"},"modified":"2021-08-21T16:03:28","modified_gmt":"2021-08-21T16:03:28","slug":"clinical-determinants-of-the-severity-of-covid-19-a-systematic-review-and-meta-analysis","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2582","title":{"rendered":"Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis"},"content":{"rendered":"\n<ul class=\"wp-block-list\" id=\"author-list\"><li>Authors: <a>Xinyang Li,<\/a> <a>Xianrui Zhong,<\/a> <a>Yongbo Wang,<\/a> <a>Xiantao Zeng,<\/a> <a>Ting Luo,<\/a><\/li><li><a>Qing Liu\u00a0<\/a>      Published: May 3, 2021<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/journals.plos.org\/resource\/img\/logo-plos.png\" alt=\"PLOS\" width=\"215\" height=\"169\"\/><\/figure>\n\n\n\n<p style=\"font-size:24px\"><strong>Abstract<br><br>Objective<\/strong><br><br>We aimed to systematically identify the possible risk factors responsible for severe cases.<\/p>\n\n\n\n<p style=\"font-size:24px\"><br><strong>Methods<\/strong><br><br>We searched PubMed, Embase, Web of science and Cochrane Library for epidemiological studies of confirmed COVID-19, which include information about clinical characteristics and severity of patients\u2019 disease. We analyzed the potential associations between clinical characteristics and severe cases.<\/p>\n\n\n\n<p style=\"font-size:24px\"><br><strong>Results<\/strong><\/p>\n\n\n\n<p style=\"font-size:24px\">We identified a total of 41 eligible studies including 21060 patients with COVID-19. Severe cases were potentially associated with advanced age (Standard Mean Difference (SMD) = 1.73, 95% CI: 1.34\u20132.12), male gender (Odds Ratio (OR) = 1.51, 95% CI:1.33\u20131.71), obesity (OR = 1.89, 95% CI: 1.44\u20132.46), history of smoking (OR = 1.40, 95% CI:1.06\u20131.85), hypertension (OR = 2.42, 95% CI: 2.03\u20132.88), diabetes (OR = 2.40, 95% CI: 1.98\u20132.91), coronary heart disease (OR: 2.87, 95% CI: 2.22\u20133.71), chronic kidney disease (CKD) (OR = 2.97, 95% CI: 1.63\u20135.41), cerebrovascular disease\u00a0<strong>(<\/strong>OR = 2.47, 95% CI: 1.54\u20133.97), chronic obstructive pulmonary disease (COPD) (OR = 2.88, 95% CI: 1.89\u20134.38), malignancy (OR = 2.60, 95% CI: 2.00\u20133.40), and chronic liver disease (OR = 1.51, 95% CI: 1.06\u20132.17). Acute respiratory distress syndrome (ARDS) (OR = 39.59, 95% CI: 19.99\u201378.41), shock (OR = 21.50, 95% CI: 10.49\u201344.06) and acute kidney injury (AKI) (OR = 8.84, 95% CI: 4.34\u201318.00) were most likely to prevent recovery. In summary, patients with severe conditions had a higher rate of comorbidities and complications than patients with non-severe conditions.<\/p>\n\n\n\n<p style=\"font-size:24px\"><strong>Conclusion<\/strong><\/p>\n\n\n\n<p style=\"font-size:24px\">Patients who were male, with advanced age, obesity, a history of smoking, hypertension, diabetes, malignancy, coronary heart disease, hypertension, chronic liver disease, COPD, or CKD are more likely to develop severe COVID-19 symptoms. ARDS, shock and AKI were thought to be the main hinderances to recovery.<\/p>\n\n\n\n<p class=\"has-large-font-size\">For More Information: <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0250602\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0250602<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors: Xinyang Li, Xianrui Zhong, Yongbo Wang, Xiantao Zeng, Ting Luo, Qing Liu\u00a0 Published: May 3, 2021 Abstract Objective We aimed to systematically identify the possible risk factors responsible for [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2583,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[663,670,742,78,96,114,227,269,286,383,503,521,524,525],"tags":[],"class_list":["post-2582","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-acute-respiratory-distress","category-age-related-outcome","category-cardiovascular-system","category-cerebrovascular-disease","category-copd","category-diabees","category-hypertension","category-kidney","category-liver","category-obesity","category-risk-factors","category-septic-shock","category-severity","category-sex-related-outcome"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2582","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2582"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2582\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2583"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2582"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2582"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}