{"id":2914,"date":"2021-08-29T18:06:17","date_gmt":"2021-08-29T18:06:17","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=2914"},"modified":"2021-08-29T18:06:17","modified_gmt":"2021-08-29T18:06:17","slug":"first-case-of-postmortem-study-in-a-patient-vaccinated-against-sars-cov-2","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=2914","title":{"rendered":"First case of postmortem study in a patient vaccinated against SARS-CoV-2"},"content":{"rendered":"\n<p>Author:<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1201971221003647#!\">TorstenHansen<sup>a<\/sup>UlfTitze<sup>a<\/sup>Nidhi Su AnnKulamadayil-Heidenreich<sup>b<\/sup>SabineGlombitza<sup>c<\/sup>Johannes,   et. al.     <\/a> <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Highlights<\/h2>\n\n\n\n<p id=\"spar0020\">\u2022 We report on a patient with a single dose of vaccine against SARS-CoV-2.<\/p>\n\n\n\n<p id=\"spar0020\">\u2022 He developed relevant serum titer levels but died 4 weeks later. <\/p>\n\n\n\n<p id=\"spar0020\">\u2022 By postmortem molecular mapping, we found\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/virus-rna\">viral RNA<\/a>\u00a0in nearly all organs examined.<\/p>\n\n\n\n<p id=\"spar0020\">\u2022 However, we did not observe any\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/morphological-trait\">characteristic morphological<\/a>\u00a0features of COVID-19.<\/p>\n\n\n\n<p id=\"spar0020\">\u2022 <a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunogenicity\">Immunogenicity<\/a>\u00a0might be elicited, while sterile immunity was not established.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p id=\"spar0025\" style=\"font-size:24px\">A previously symptomless 86-year-old man received the first dose of the BNT162b2 mRNA COVID-19 vaccine. He died 4 weeks later from acute renal and respiratory failure. Although he did not present with any COVID-19-specific symptoms, he tested positive for SARS-CoV-2 before he died. Spike protein (S1) antigen-binding showed significant levels for immunoglobulin (Ig) G, while nucleocapsid IgG\/IgM was not elicited. Acute bronchopneumonia and tubular failure were assigned as the cause of death at autopsy; however, we did not observe any characteristic morphological features of COVID-19. Postmortem molecular mapping by real-time polymerase chain reaction revealed relevant SARS-CoV-2 cycle threshold values in all organs examined (oropharynx, olfactory mucosa, trachea, lungs, heart, kidney and cerebrum) except for the liver and olfactory bulb. These results might suggest that the first vaccination induces immunogenicity but not sterile immunity.<\/p>\n\n\n\n<ul class=\"wp-block-list\" id=\"issue-navigation\"><li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1201971221003271\"><strong>Previous&nbsp;<\/strong>article&nbsp;in issue<\/a><\/li><li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1201971221003787\"><strong>Next&nbsp;<\/strong>article&nbsp;in issue<\/a><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Keywords<\/h2>\n\n\n\n<p style=\"font-size:24px\">SARS-CoV-2VaccineAutopsyHistologyRT-PCR<\/p>\n\n\n\n<p id=\"par0030\" style=\"font-size:24px\">We report on an 86-year-old male resident of a retirement home who received vaccine against SARS-CoV-2. Past medical history included\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/systemic-hypertension\">systemic arterial hypertension<\/a>,\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chronic-venous-insufficiency\">chronic venous insufficiency<\/a>,\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dementia\">dementia<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/prostate-carcinoma\">prostate carcinoma<\/a>. On January 9, 2021, the man received lipid nanoparticle-formulated, nucleoside-modified\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rna-vaccine\">RNA vaccine<\/a>\u00a0BNT162b2 in a 30 \u03bcg dose. On that day and in the following 2 weeks, he presented with no clinical symptoms (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1201971221003647#tbl0005\">Table 1<\/a>). On day 18, he was admitted to hospital for worsening diarrhea. Since he did not present with any clinical signs of COVID-19, isolation in a specific setting did not occur. Laboratory testing revealed\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hypochromic-anemia\">hypochromic anemia<\/a>\u00a0and increased\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/creatinine-blood-level\">creatinine serum<\/a>\u00a0levels. Antigen test and\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/polymerase-chain-reaction\">polymerase chain reaction<\/a>\u00a0(PCR) for SARS-CoV-2 were negative.<\/p>\n\n\n\n<p class=\"has-large-font-size\">For More Information: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1201971221003647\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1201971221003647<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Author:TorstenHansenaUlfTitzeaNidhi Su AnnKulamadayil-HeidenreichbSabineGlombitzacJohannes, et. al. Highlights \u2022 We report on a patient with a single dose of vaccine against SARS-CoV-2. \u2022 He developed relevant serum titer levels but died 4 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2915,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[776,803,827,332,375,422,946,607,608,631,632,633,640],"tags":[],"class_list":["post-2914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-deaths","category-failure","category-histopathology","category-mortality","category-news-of-the-day","category-pathology","category-side-effects","category-vaccine-news","category-vaccine-safety","category-virus","category-virus-propagation","category-virus-replication","category-waning-effectiveness"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2914"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/2914\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/2915"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}