{"id":4880,"date":"2022-06-22T12:40:29","date_gmt":"2022-06-22T12:40:29","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=4880"},"modified":"2022-06-22T12:40:29","modified_gmt":"2022-06-22T12:40:29","slug":"covid-19-vaccination-bnt162b2-temporarily-impairs-semen-concentration-and-total-motile-count-among-semen-donors","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=4880","title":{"rendered":"Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count among semen donors"},"content":{"rendered":"\n

Authors: Itai Gat<\/a>,Alon Kedem<\/a>,Michal Dviri<\/a>,Ana Umanski<\/a>,Matan Levi<\/a>,Ariel Hourvitz<\/a>,Micha Baum<\/a> 17 June 2022 <\/a><\/p>\n\n\n\n

Abstract<\/h3>\n\n\n\n

Background<\/h3>\n\n\n\n

The development of covid-19 vaccinations represents a notable scientific achievement. Nevertheless, concerns have been raised regarding their possible detrimental impact on male fertility<\/p>\n\n\n\n

Objective<\/h3>\n\n\n\n

To investigate the effect of covid-19 BNT162b2 (Pfizer) vaccine on semen parameters among semen donors (SD).<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

37 SD from three sperm banks that provided 220 samples, were included in that retrospective longitudinal multicenter cohort study. BNT162b2 vaccination included two doses, and vaccination completion was scheduled 7 days after the second dose. The study included four phases: T0 \u2013 pre-vaccination baseline control, which encompassed 1\u20132 initial samples per SD; T1, T2 and T3 \u2013 short, intermediate, and long terms evaluations, respectively. Each included 1\u20133 semen samples per donor provided 15\u201345, 75-120, and over 150 days after vaccination completion, respectively. The primary endpoints were semen parameters. Three statistical analyses were conducted: 1) generalized estimated equation model; 2) first sample and 3) samples’ mean of each donor per period were compared to T0.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

Repetitive measurements revealed \u221215.4% sperm concentration decrease on T2 (CI -25.5%\u20133.9%, p = 0.01) leading to total motile count 22.1% reduction (CI -35% – -6.6%, p = 0.007) compared to T0. Similarly, analysis of first semen sample only and samples’ mean per donor resulted in concentration and TMC reductions on T2 compared to T0 – median decline of 12 million\/ml and 31 million motile spermatozoa, respectively (p = 0.02 and 0.002 respectively) on first sample evaluation and median decline of 9.5\u00d7106<\/sup> and 27.3 million motile spermatozoa (p = 0.004 and 0.003, respectively) on samples’ mean examination. T3 evaluation demonstrated overall recovery. Semen volume and sperm motility were not impaired.<\/p>\n\n\n\n

Discussion<\/h3>\n\n\n\n

This longitudinal study focused on SD demonstrates selective temporary sperm concentration and TMC deterioration three months after vaccination followed by later recovery verified by diverse statistical analyses.<\/p>\n\n\n\n

Conclusions<\/h3>\n\n\n\n

Systemic immune response after BNT162b2 vaccine is a reasonable cause for transient semen concentration and TMC decline. Long-term prognosis remains good.<\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Itai Gat,Alon Kedem,Michal Dviri,Ana Umanski,Matan Levi,Ariel Hourvitz,Micha Baum 17 June 2022 Abstract Background The development of covid-19 vaccinations represents a notable scientific achievement. Nevertheless, concerns have been raised regarding […]<\/p>\n","protected":false},"author":2,"featured_media":4885,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[761,858,570,608],"tags":[],"class_list":["post-4880","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-concerns","category-lowered-sperm-counts","category-testes","category-vaccine-safety"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/4880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4880"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/4880\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/4885"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}