{"id":5729,"date":"2022-11-03T06:00:00","date_gmt":"2022-11-03T06:00:00","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=5729"},"modified":"2022-11-03T06:00:00","modified_gmt":"2022-11-03T06:00:00","slug":"omicron-specific-boosters-fail-to-show-benefit-over-original-shots-study-finds","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=5729","title":{"rendered":"Omicron-specific boosters fail to show benefit over original shots, study finds"},"content":{"rendered":"\n<p>by&nbsp;<a href=\"https:\/\/12ft.io\/proxy?ref=&amp;q=https:\/\/www.washingtonexaminer.com\/author\/abigail-adcox\">Abigail Adcox, Healthcare Reporter<\/a>  October 25, 2022  Washington Examiner<\/p>\n\n\n\n<p>who had received three shots with the original formula and a fourth shot of Moderna\u2019s or&nbsp;<a href=\"https:\/\/12ft.io\/proxy?ref=&amp;q=https:\/\/www.washingtonexaminer.com\/tag\/pfizer\">Pfizer-BioNTech\u2019s<\/a>&nbsp;omicron booster compared to 19 people who had received four shots targeting the original strain.<\/p>\n\n\n\n<p>The study suggests that the omicron booster may not protect people from getting infected with the highly transmissible subvariant BA.5, which accounts for most COVID-19 cases in the U.S. currently, any more than the previous shots, despite the updated boosters being formulated to provide better protection against infection and severe disease against the current strains.<\/p>\n\n\n\n<p>\u201cWhen given as a fourth dose, a bivalent mRNA vaccine targeting Omicron BA.4\/BA.5 and an ancestral SARS-CoV-2 strain did not induce superior neutralizing antibody responses in humans, at the time period tested, compared to the original monovalent vaccine formulation,\u201d the researchers&nbsp;<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.10.22.513349v1.full.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">wrote<\/a>.<\/p>\n\n\n\n<p>The updated boosters have a new vaccine formula that targets both the original strain of the virus from 2020 and the omicron subvariants BA.4 and BA.5.<\/p>\n\n\n\n<p>While researchers noted that further follow-up studies were needed, the results are some of the first tracking how the omicron booster stands against previous ones. It also starkly differs from early data released by vaccine manufacturers Pfizer-BioNTech and Moderna earlier this month from clinical trials. Pfizer-BioNTech said that their omicron booster showed a \u201csubstantial increase\u201d in antibody levels compared to pre-booster levels.<\/p>\n\n\n\n<p>Moderna also&nbsp;<a href=\"https:\/\/investors.modernatx.com\/news\/news-details\/2022\/90-Day-Analysis-Shows-Modernas-Omicron-BA.1-Targeting-Bivalent-Vaccine-mRNA-1273.214-Demonstrates-Superior-Antibody-Response-as-Fourth-Booster-Compared-to-Spikevax-Prototype-Booster\/default.aspx\" target=\"_blank\" rel=\"noreferrer noopener\">said<\/a>&nbsp;early data from clinical trials indicated that the omicron booster had a \u201csuperior immune response.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>by&nbsp;Abigail Adcox, Healthcare Reporter October 25, 2022 Washington Examiner who had received three shots with the original formula and a fourth shot of Moderna\u2019s or&nbsp;Pfizer-BioNTech\u2019s&nbsp;omicron booster compared to 19 people [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":5731,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[725,803,387,607],"tags":[],"class_list":["post-5729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-booster-shot","category-failure","category-omicron","category-vaccine-news"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/5729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5729"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/5729\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/5731"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}