{"id":5872,"date":"2022-12-04T06:00:00","date_gmt":"2022-12-04T06:00:00","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=5872"},"modified":"2022-12-04T06:00:00","modified_gmt":"2022-12-04T06:00:00","slug":"covid-19-inflammation-results-in-urine-cytokine-elevation-and-causes-covid-19-associated-cystitis-cac","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=5872","title":{"rendered":"COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC)"},"content":{"rendered":"\n<p>Authors: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lamb+LE&amp;cauthor_id=33213997\">Laura E Lamb<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33213997\/#affiliation-1\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Dhar+N&amp;cauthor_id=33213997\">Nivedita Dhar<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33213997\/#affiliation-2\">2<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Timar+R&amp;cauthor_id=33213997\">Ryan Timar<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33213997\/#affiliation-3\">3<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Wills+M&amp;cauthor_id=33213997\">Melissa Wills<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33213997\/#affiliation-3\">3<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Dhar+S&amp;cauthor_id=33213997\">Sorabh Dhar<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33213997\/#affiliation-4\">4<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Chancellor+MB&amp;cauthor_id=33213997\">Michael B Chancellor<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33213997\/#affiliation-5\">5<\/a><\/sup>  PMID:&nbsp;<strong>33213997<\/strong> PMCID:&nbsp;<a rel=\"noreferrer noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7644255\/\" target=\"_blank\">PMC7644255<\/a> DOI:&nbsp;<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1016\/j.mehy.2020.110375\" target=\"_blank\">10.1016\/j.mehy.2020.110375<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>Coronavirus disease 2019 (COVID-19) causes a wide range of symptoms, including several unexpected symptoms such as loss of taste, skin changes, and eye problems. We recently observed patients with documented COVID-19 develop de novo severe genitourinary symptoms, most notably urinary frequency of \u2265 13 episodes\/24 h and nocturia \u2265 4 episodes\/night. We call these associated urinary symptoms COVID-19 associate cystitis (CAC). COVID-19 severity is associated with inflammation. We collected urine samples from COVID-19 patients, including patients with CAC, and found elevation of proinflammatory cytokines also in the urine. It has been previously shown that patients with urinary incontinence and ulcerative interstitial cystitis\/bladder pain syndrome have elevated urinary inflammatory cytokines compared to normal controls. We therefore hypothesize that CAC, with presentation of de novo severe urinary symptoms, can occur in COVID-19 and is caused by increased inflammatory cytokines that are released into the urine and\/or expressed in the bladder. The most important implications of our hypothesis are: 1) Physician caring for COVID-19 patients should be aware of COVID-19 associate cystitis (CAC); 2) De novo urinary symptoms should be included in the symptom complex associated with COVID-19; and 3) COVID-19 inflammation may result in bladder dysfunction.<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"<p>Authors: Laura E Lamb&nbsp;1,&nbsp;Nivedita Dhar&nbsp;2,&nbsp;Ryan Timar&nbsp;3,&nbsp;Melissa Wills&nbsp;3,&nbsp;Sorabh Dhar&nbsp;4,&nbsp;Michael B Chancellor&nbsp;5 PMID:&nbsp;33213997 PMCID:&nbsp;PMC7644255 DOI:&nbsp;10.1016\/j.mehy.2020.110375 Abstract Coronavirus disease 2019 (COVID-19) causes a wide range of symptoms, including several unexpected symptoms such as [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":5894,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50,107,840,252,253],"tags":[],"class_list":["post-5872","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bladder","category-cytokine-storm-covid-19","category-inflammasome","category-inflammation","category-inflammation-2"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/5872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5872"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/5872\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/5894"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}