{"id":6040,"date":"2023-08-22T15:33:36","date_gmt":"2023-08-22T15:33:36","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=6040"},"modified":"2023-08-22T15:33:36","modified_gmt":"2023-08-22T15:33:36","slug":"sars-cov-2-infection-and-persistence-in-the-human-body-and-brain-at-autopsy","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=6040","title":{"rendered":"SARS-CoV-2 infection and persistence in the human body and brain at autopsy"},"content":{"rendered":"\n<p>Authors: by\u00a0<a href=\"https:\/\/www.covidstrategies.org\/author\/web\/\">Covid Strategies<\/a>\u00a0|\u00a0Dec 14, 2022\u00a0|\u00a0<a href=\"https:\/\/www.covidstrategies.org\/topic\/science-news\/\">Science &amp; News<\/a> Nature<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"Abs1\">Abstract<\/h2>\n\n\n\n<p>Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR1\">1<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR2\">2<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR3\">3<\/a><\/sup>&nbsp;during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients experiencing prolonged symptoms, termed post-acute sequelae of SARS-CoV-2 (refs.\u2009<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR4\">4<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR5\">5<\/a><\/sup>). However, the burden of infection outside the respiratory tract and time to viral clearance are not well characterized, particularly in the brain<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR3\">3<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR6\">6<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR7\">7<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR8\">8<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR9\">9<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR10\">10<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR11\">11<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR12\">12<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR13\">13<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05542-y#ref-CR14\">14<\/a><\/sup>. Here we carried out complete autopsies on 44 patients who died with COVID-19, with extensive sampling of the central nervous system in 11 of these patients, to map and quantify the distribution, replication and cell-type specificity of SARS-CoV-2 across the human body, including the brain, from acute infection to more than seven months following symptom onset. We show that SARS-CoV-2 is widely distributed, predominantly among patients who died with severe COVID-19, and that virus replication is present in multiple respiratory and non-respiratory tissues, including the brain, early in infection. Further, we detected persistent SARS-CoV-2 RNA in multiple anatomic sites, including throughout the brain, as late as 230 days following symptom onset in one case. Despite extensive distribution of SARS-CoV-2 RNA throughout the body, we observed little evidence of inflammation or direct viral cytopathology outside the respiratory tract. Our data indicate that in some patients SARS-CoV-2 can cause systemic infection and persist in the body for months.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors: by\u00a0Covid Strategies\u00a0|\u00a0Dec 14, 2022\u00a0|\u00a0Science &amp; News Nature Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction1,2,3&nbsp;during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":6685,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[403,422],"tags":[],"class_list":["post-6040","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-organ-failure","category-pathology"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/6040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6040"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/6040\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/6685"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}