{"id":7560,"date":"2023-10-04T06:00:00","date_gmt":"2023-10-04T06:00:00","guid":{"rendered":"http:\/\/www.cov19longhaulfoundation.org\/?p=7560"},"modified":"2023-10-04T06:00:00","modified_gmt":"2023-10-04T06:00:00","slug":"vagus-nerve-inflammation-contributes-to-dysautonomia-in-covid-19","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=7560","title":{"rendered":"Vagus nerve inflammation contributes to dysautonomia in COVID-19"},"content":{"rendered":"\n

Marcel S Woo\u00a01<\/a><\/sup>,\u00a0Mohsin Shafiq\u00a02<\/a><\/sup>,\u00a0Antonia Fitzek\u00a03<\/a><\/sup>,\u00a0Matthias Dottermusch\u00a02<\/a><\/sup>,\u00a0Hermann Altmeppen\u00a02<\/a><\/sup>,\u00a0Behnam Mohammadi\u00a02<\/a><\/sup>,\u00a0Christina Mayer\u00a01<\/a><\/sup>,\u00a0Lukas C Bal\u00a01<\/a><\/sup>,\u00a0Lukas Raich\u00a01<\/a><\/sup>,\u00a0Jakob Matschke\u00a02<\/a><\/sup>,\u00a0Susanne Krasemann\u00a02<\/a><\/sup>,\u00a0Susanne Pfefferle\u00a04<\/a><\/sup>,\u00a0Thomas Theo Brehm\u00a05<\/a>\u00a06<\/a><\/sup>,\u00a0Marc L\u00fctgehetmann\u00a04<\/a><\/sup>,\u00a0Julia Sch\u00e4dler\u00a03<\/a><\/sup>,\u00a0Marylyn M Addo\u00a05<\/a>\u00a06<\/a>\u00a07<\/a><\/sup>,\u00a0Julian Schulze Zur Wiesch\u00a05<\/a>\u00a06<\/a><\/sup>,\u00a0Benjamin Ondruschka\u00a03<\/a><\/sup>,\u00a0Manuel A Friese\u00a0#<\/a>\u00a08<\/a><\/sup>,\u00a0Markus Glatzel\u00a0#<\/a>\u00a09<\/a><\/sup><\/p>\n\n\n\n

PMID:\u00a037452829<\/strong> PMCID:\u00a0PMC10412500<\/a> DOI:\u00a010.1007\/s00401-023-02612-x<\/a><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Dysautonomia has substantially impacted acute COVID-19 severity as well as symptom burden after recovery from COVID-19 (long COVID), yet the underlying causes remain unknown. Here, we hypothesized that vagus nerves are affected in COVID-19 which might contribute to autonomic dysfunction. We performed a histopathological characterization of postmortem vagus nerves from COVID-19 patients and controls, and detected SARS-CoV-2 RNA together with inflammatory cell infiltration composed primarily of monocytes. Furthermore, we performed RNA sequencing which revealed a strong inflammatory response of neurons, endothelial cells, and Schwann cells which correlated with SARS-CoV-2 RNA load. Lastly, we screened a clinical cohort of 323 patients to detect a clinical phenotype of vagus nerve affection and found a decreased respiratory rate in non-survivors of critical COVID-19. Our data suggest that SARS-CoV-2 induces vagus nerve inflammation followed by autonomic dysfunction which contributes to critical disease courses and might contribute to dysautonomia observed in long COVID.<\/p>\n\n\n\n

Keywords: <\/strong>COVID-19; Dysautonomia; Neuroinflammation; Vagus nerve.<\/p>\n\n\n\n

\u00a9 2023. The Author(s).<\/p>\n\n\n\n

Figures<\/p>\n\n\n\n

\"Fig.<\/a><\/figure>\n\n\n\n
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References<\/h2>\n\n\n\n
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  1. Carmona-Torre F, M\u00ednguez-Olaondo A, L\u00f3pez-Bravo A, Tijero B, Grozeva V, Walcker M, Azkune-Galparsoro H, L\u00f3pez de Munain A, Alcaide AB, Quiroga J, del Pozo JL, G\u00f3mez-Esteban JC. Dysautonomia in COVID-19 patients: a narrative review on clinical course, diagnostic and therapeutic strategies. Front Neurol. 2022 doi: 10.3389\/fneur.2022.886609. – DOI <\/a>– PMC <\/a>– PubMed<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Marcel S Woo\u00a01,\u00a0Mohsin Shafiq\u00a02,\u00a0Antonia Fitzek\u00a03,\u00a0Matthias Dottermusch\u00a02,\u00a0Hermann Altmeppen\u00a02,\u00a0Behnam Mohammadi\u00a02,\u00a0Christina Mayer\u00a01,\u00a0Lukas C Bal\u00a01,\u00a0Lukas Raich\u00a01,\u00a0Jakob Matschke\u00a02,\u00a0Susanne Krasemann\u00a02,\u00a0Susanne Pfefferle\u00a04,\u00a0Thomas Theo Brehm\u00a05\u00a06,\u00a0Marc L\u00fctgehetmann\u00a04,\u00a0Julia Sch\u00e4dler\u00a03,\u00a0Marylyn M Addo\u00a05\u00a06\u00a07,\u00a0Julian Schulze Zur Wiesch\u00a05\u00a06,\u00a0Benjamin Ondruschka\u00a03,\u00a0Manuel A Friese\u00a0#\u00a08,\u00a0Markus Glatzel\u00a0#\u00a09 PMID:\u00a037452829 PMCID:\u00a0PMC10412500 […]<\/p>\n","protected":false},"author":2,"featured_media":7601,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[129,252,611],"tags":[],"class_list":["post-7560","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dysautonomia","category-inflammation","category-vagus-nerve"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/7560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7560"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/7560\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/7601"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}