{"id":849,"date":"2021-07-20T21:18:34","date_gmt":"2021-07-20T21:18:34","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=849"},"modified":"2021-07-20T21:18:34","modified_gmt":"2021-07-20T21:18:34","slug":"what-is-the-role-of-t-cells-in-covid-19-infection-why-immunity-is-about-more-than-antibodies","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=849","title":{"rendered":"What is the role of T cells in COVID-19 infection? Why immunity is about more than antibodies"},"content":{"rendered":"\n<p style=\"font-size:26px\"><strong>Summary<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\" style=\"font-size:24px\"><li>CD4+ T cells help B cells to produce antibodies and help CD8+ T cells to kill virus-infected cells<\/li><li>One of the dominant cytokines produced by T cells is interferon gamma, a key player in controlling viral infection \u2013 see also [<a href=\"https:\/\/www.cebm.net\/covid-19\/drug-vignettes-interferons\/\">41<\/a>]<\/li><li>Lymphopenia is a main feature of COVID-19 infection, affecting CD4+ T cells, CD8+ T cells, and B cells, and is more pronounced in severely ill patients<\/li><li>T cell responses in severely ill patients may be impaired, over-activated, or inappropriate, and further research is required to elucidate this and inform treatment strategies<\/li><li>There is some evidence of cross-reactivity with seasonal\/endemic coronaviruses<\/li><li>Emerging studies suggest that all or a majority of people with COVID-19 develop a strong and broad T cell response, both CD4 and CD8, and some have a memory phenotype, which bodes well for potential longer-term immunity<\/li><li>Understanding the roles of different subsets of T cells in protection or pathogenesis is crucial for preventing and treating COVID-19<\/li><\/ul>\n\n\n\n<p class=\"has-large-font-size\">For More Information: <a href=\"https:\/\/www.cebm.net\/covid-19\/what-is-the-role-of-t-cells-in-covid-19-infection-why-immunity-is-about-more-than-antibodies\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.cebm.net\/covid-19\/what-is-the-role-of-t-cells-in-covid-19-infection-why-immunity-is-about-more-than-antibodies\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary CD4+ T cells help B cells to produce antibodies and help CD8+ T cells to kill virus-infected cells One of the dominant cytokines produced by T cells is interferon [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":850,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[982,985,987,836,964],"tags":[],"class_list":["post-849","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-b-cell","category-cd4","category-cd8","category-immune-system","category-t-cell"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=849"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/849\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/850"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}