{"id":8550,"date":"2023-12-12T06:00:00","date_gmt":"2023-12-12T11:00:00","guid":{"rendered":"http:\/\/www.cov19longhaulfoundation.org\/?p=8550"},"modified":"2023-12-12T06:00:00","modified_gmt":"2023-12-12T11:00:00","slug":"skeletal-muscle-injury-in-covid-infection-frequency-and-patterns","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=8550","title":{"rendered":"Skeletal muscle injury in COVID infection: Frequency and patterns"},"content":{"rendered":"\n

Saurabh Singh Rajput MBBS, MD, DM,\u00a0Rajeswari Aghoram MBBS, MD, DM,\u00a0Vaibhav Wadwekar MBBS, MD, DM PDF,\u00a0Nivedita Nanda MBBS, MD<\/a>, October 2023, Muscle & Nerve<\/a>Volume 68, Issue 6<\/a>\u00a0p. 873-878<\/a><\/p>\n\n\n\n

Abstract<\/h3>\n\n\n\n

Introduction\/Aims<\/h3>\n\n\n\n

Little is known about skeletal muscle injury with coronavirus disease 2019 (COVID-19). We estimate the frequency and explore the patterns of skeletal muscle injury in acute COVID-19.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

A cohort of COVID patients with mild to moderate symptoms were evaluated in a COVID-designated hospital between May and December 2021 and followed for 2\u2009weeks. Skeletal muscle injury was assessed according to creatine kinase (CK) levels, Manual Muscle Test-8 (MMT-8) score, and the Health Assessment Questionnaire (HAQ) score. Injury was defined as CK >200\u2009IU\/L with an MMT-8 score\u2009<\u200976. The association between such injury and severity and outcomes were evaluated using cross-tabulations.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

Two hundred fifty participants with a mean age of 50.2\u2009years (SD: 17.2) were included. One hundred nine (43.6%) were women; 84 (34%) developed severe disease. Median CK levels were 91\u2009IU\/L (IQR 56\u2013181). [Correction added on 17 November 2023, after first online publication: In the preceding sentence, the IQR was corrected from \u201856,181\u2019.] Patients with weakness on the MMT-8 (n<\/em> = 247, 98.8%) and disability on the HAQ (n<\/em> = 107; 42.8%) were common. Neck flexor muscles were prominently affected. Skeletal muscle injury was seen in 22.4% (95% CI: 17.4\u201328.1). There was no significant association between skeletal muscle injury and maximal severity of illness or short-term outcomes. Disability increased over 14\u2009days in most survivors (n<\/em> = 172, 72.3%) and this was not seen in those with mild disease (OR: 0.4, 95% CI: 0.22\u20130.70).<\/p>\n\n\n\n

Discussion<\/h3>\n\n\n\n

Skeletal muscle injury appears to be common in people presenting with mild to moderate COVID infection.<\/p>\n","protected":false},"excerpt":{"rendered":"

Saurabh Singh Rajput MBBS, MD, DM,\u00a0Rajeswari Aghoram MBBS, MD, DM,\u00a0Vaibhav Wadwekar MBBS, MD, DM PDF,\u00a0Nivedita Nanda MBBS, MD, October 2023, Muscle & NerveVolume 68, Issue 6\u00a0p. 873-878 Abstract Introduction\/Aims Little […]<\/p>\n","protected":false},"author":2,"featured_media":8614,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[344,881,882],"tags":[],"class_list":["post-8550","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-muscle-joints","category-musculoskeletal","category-myalgia-muscle-pain"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/8550","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8550"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/8550\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/8614"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}