{"id":8728,"date":"2023-12-22T18:00:00","date_gmt":"2023-12-22T23:00:00","guid":{"rendered":"http:\/\/www.cov19longhaulfoundation.org\/?p=8728"},"modified":"2023-12-22T18:00:00","modified_gmt":"2023-12-22T23:00:00","slug":"trajectory-of-long-covid-symptoms-after-covid-19-vaccination-community-based-cohort-study","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=8728","title":{"rendered":"Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study"},"content":{"rendered":"\n

Daniel Ayoubkhani<\/a>\u00a01<\/a>\u00a02<\/a><\/sup>,\u00a0Charlotte Bermingham<\/a>\u00a03<\/a><\/sup>,\u00a0Koen B Pouwels<\/a>\u00a04<\/a>\u00a05<\/a><\/sup>,\u00a0Myer Glickman<\/a>\u00a03<\/a><\/sup>,\u00a0Vah\u00e9 Nafilyan<\/a>\u00a03<\/a>\u00a06<\/a><\/sup>,\u00a0Francesco Zaccardi<\/a>\u00a02<\/a><\/sup>,\u00a0Kamlesh Khunti<\/a>\u00a02<\/a><\/sup>,\u00a0Nisreen A Alwan<\/a>\u00a07<\/a>\u00a08<\/a>\u00a09<\/a><\/sup>,\u00a0A Sarah Walker<\/a>\u00a04<\/a>\u00a010<\/a><\/sup> PMID:\u00a035584816<\/strong>, PMCID:\u00a0PMC9115603<\/a> , DOI:\u00a010.1136\/bmj-2021-069676<\/a><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Objective: <\/strong>To estimate associations between covid-19 vaccination and long covid symptoms in adults with SARS-CoV-2 infection before vaccination.<\/p>\n\n\n\n

Design: <\/strong>Observational cohort study.<\/p>\n\n\n\n

Setting: <\/strong>Community dwelling population, UK.<\/p>\n\n\n\n

Participants: <\/strong>28 356 participants in the Office for National Statistics COVID-19 Infection Survey aged 18-69 years who received at least one dose of an adenovirus vector or mRNA covid-19 vaccine after testing positive for SARS-CoV-2 infection.<\/p>\n\n\n\n

Main outcome measure: <\/strong>Presence of long covid symptoms at least 12 weeks after infection over the follow-up period 3 February to 5 September 2021.<\/p>\n\n\n\n

Results: <\/strong>Mean age of participants was 46 years, 55.6% (n=15 760) were women, and 88.7% (n=25 141) were of white ethnicity. Median follow-up was 141 days from first vaccination (among all participants) and 67 days from second vaccination (83.8% of participants). 6729 participants (23.7%) reported long covid symptoms of any severity at least once during follow-up. A first vaccine dose was associated with an initial 12.8% decrease (95% confidence interval -18.6% to -6.6%, P<0.001) in the odds of long covid, with subsequent data compatible with both increases and decreases in the trajectory (0.3% per week, 95% confidence interval -0.6% to 1.2% per week, P=0.51). A second dose was associated with an initial 8.8% decrease (95% confidence interval -14.1% to -3.1%, P=0.003) in the odds of long covid, with a subsequent decrease by 0.8% per week (-1.2% to -0.4% per week, P<0.001). Heterogeneity was not found in associations between vaccination and long covid by sociodemographic characteristics, health status, hospital admission with acute covid-19, vaccine type (adenovirus vector or mRNA), or duration from SARS-CoV-2 infection to vaccination.<\/p>\n\n\n\n

Conclusions: <\/strong>The likelihood of long covid symptoms was observed to decrease after covid-19 vaccination and evidence suggested sustained improvement after a second dose, at least over the median follow-up of 67 days. Vaccination may contribute to a reduction in the population health burden of long covid, although longer follow-up is needed.<\/p>\n","protected":false},"excerpt":{"rendered":"

Daniel Ayoubkhani\u00a01\u00a02,\u00a0Charlotte Bermingham\u00a03,\u00a0Koen B Pouwels\u00a04\u00a05,\u00a0Myer Glickman\u00a03,\u00a0Vah\u00e9 Nafilyan\u00a03\u00a06,\u00a0Francesco Zaccardi\u00a02,\u00a0Kamlesh Khunti\u00a02,\u00a0Nisreen A Alwan\u00a07\u00a08\u00a09,\u00a0A Sarah Walker\u00a04\u00a010 PMID:\u00a035584816, PMCID:\u00a0PMC9115603 , DOI:\u00a010.1136\/bmj-2021-069676 Abstract Objective: To estimate associations between covid-19 vaccination and long covid symptoms in adults […]<\/p>\n","protected":false},"author":2,"featured_media":8730,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[289,607],"tags":[],"class_list":["post-8728","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-long-haul-disease","category-vaccine-news"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/8728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8728"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/8728\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/8730"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}