{"id":8733,"date":"2023-12-22T18:00:00","date_gmt":"2023-12-22T23:00:00","guid":{"rendered":"http:\/\/www.cov19longhaulfoundation.org\/?p=8733"},"modified":"2023-12-22T18:00:00","modified_gmt":"2023-12-22T23:00:00","slug":"some-covid-vaccines-produce-unintended-immune-response-in-recipients-study","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=8733","title":{"rendered":"Some COVID Vaccines Produce ‘Unintended Immune Response’ In Recipients: Study"},"content":{"rendered":"\n

DEC 11, 2023 – Authored by Naveen Athrappully via The Epoch Times<\/em><\/p>\n\n\n\n

Researchers in a landmark new study have discovered a sequence within the Pfizer mRNA vaccine that produces an \u201cunintended immune response\u201d in the body,\u00a0<\/strong>which experts are calling a massive \u201cdevelopmental and regulatory failure.\u201d<\/a><\/p>\n\n\n\n

Synthetic Messenger Ribonucleic Acid (mRNA), such as that used in Moderna and Pfizer vaccines, enables the body to create a specific spike protein mimicking SARS-CoV-2. The body reacts to the foreign protein and generates protective immunity, which theoretically neutralizes the real virus when it enters the body.<\/p>\n\n\n\n

\u201cResearchers from the Medical Research Council (MRC) Toxicology Unit have discovered that the cellular machinery that \u2018reads\u2019 mRNAs \u2018slips\u2019 when confronted with repeats of a chemical modification commonly found in mRNA therapeutics.<\/strong> In addition to the target protein, these slips lead to the production of \u2018off-target\u2019 proteins triggering an unintended immune response,\u201d said a press release<\/a> for the study published in Nature on Dec. 6.<\/p>\n\n\n\n

The MRC team redesigned the mRNA vaccine to prevent further harmful immune responses from the spike proteins.<\/p>\n\n\n\n

\u201cThe researchers identified that bases with a chemical modification called N1-methylpseudouridine\u2014which are currently contained in mRNA therapies\u2014are responsible for the \u2018slips\u2019 along the mRNA sequence.\u201d<\/p>\n\n\n\n

When the MRC team collaborated with researchers from the Universities of Kent, Oxford, and Liverpool, they found an unintended immune response occurred in one-third of the 21 patients in the study who were inoculated with the Pfizer mRNA vaccine.<\/p>\n\n\n\n

Re-Engineering mRNA<\/h2>\n\n\n\n

The team reengineered the error-prone genetic sequences in the synthetic mRNA to avoid these unintended and \u201coff-target\u201d effects.<\/p>\n\n\n\n

\u201cWe can remove the error-prone code from the mRNA in vaccines so the body will make the proteins we want for an immune response without inadvertently making other proteins as well.<\/strong> The safety concern for future mRNA medicines is that misdirected immunity has huge potential to be harmful, so off-target immune responses should always be avoided,\u201d said Dr. James Thaventhiran from the MRC team, who is also a practicing clinician at Addenbrooke\u2019s hospital.<\/p>\n\n\n\n

Biochemist Professor and MRC team member Anne Willis said that the redesigning work presents \u201cboth a concern and a solution for this new type of medicine.\u201d<\/p>\n\n\n\n

Ribosomes in cells produce proteins from natural and synthetic mRNAs, and a precise positioning of the ribosome on the mRNA is needed to make the right proteins. The ribosome \u2018reads\u2019 the mRNA sequence three bases at a time, and any tiny deviation that happens here \u201cmassively distorts the code and the resulting protein,\u201d said the Cambridge press release.<\/p>\n\n\n\n

When the ribosome misreads the mRNA and ends up with unintended amino acids, the mutation is known as a frameshift.<\/p>\n\n\n\n

\u201cWhen the ribosome is confronted with a string of these modified bases called N1-methylpseudouridine in the mRNA, it slips around 10% of the time, causing the mRNA to be misread and unintended proteins to be produced\u2014enough to trigger an immune response. Removing these runs of N1-methylpseudouridine from the mRNAs prevents \u2018off-target\u2019 protein production.\u201d<\/p>\n\n\n\n

This research was funded by the Medical Research Council and the Wellcome LEAP R3 program, and supported by the NIHR Cambridge BRC. As for competing interests, two of the authors in the study are inventors on a pending patent application (2305297.0) related to mRNA technology.<\/p>\n\n\n\n

Fundamental Failure<\/h2>\n\n\n\n

Although the MRC team insisted that the unintended immune responses were found to have no ill effects, expert responses to the study claimed the safety concern revealed a more fundamental failure of the scientific and regulatory communities in approving the COVID mRNA vaccines.<\/p>\n\n\n\n

\u201cThe formation of these off-target proteins is not disclosed in the package insert for COMIRNATY,\u201d said a commentary on the study published in ResearchGate<\/a>. \u201cThe finding that unintended proteins may be produced as a result of vaccination is sufficient cause for regulators to conduct full risk assessments of past or future harms that may have ensued.\u201d<\/p>\n\n\n\n

Authors said that according to WHO guidelines for mRNA vaccines, \u201cmanufacturers should provide details of \u2018unexpected ORFs\u2019 (Open Reading Frames),<\/strong>\u201d referring to cellular modification on a DNA level.<\/p>\n\n\n\n

\u201cGiven that this study was conducted under the auspices of the United Kingdom Government, we must assume UK regulators, manufacturers, and international regulatory agencies, including FDA, were apprised of the data many months ago.<\/p>\n\n\n\n

\u201cWe await their account of what steps they have taken to investigate why the formation of off-target proteins was not discovered sooner, what toxic effects they may have caused, and what steps they are taken to prevent harm in the future and to inform the public of these findings.\u201d<\/p>\n\n\n\n

The Epoch Times reached out to Pfizer, Moderna, the FDA, and the CDC for comment.<\/p>\n\n\n\n

Social Responses<\/h2>\n\n\n\n

In a Dec. 6 post on X, Dr. Jonathan Engler<\/a> said: \u201cThis is devastating. A design flaw in the mRNA injections results in them making random proteins which will be massively pro-inflammatory. Because the product is distributed throughout the body, this happens everywhere<\/strong>. This likely explains the huge variety of immune disorders reported in association with these products.\u201d<\/p>\n\n\n\n

Supporters of the study claimed that critics were making an issue unnecessarily.<\/p>\n\n\n\n

\u201cFrameshifts are uncommon but naturally occurring events in, for example, viral infections,\u201d said Edward Nirenberg<\/a>, a medical publisher. \u201cThese give rise to protein products that can also be targeted by the immune system.\u201d<\/p>\n\n\n\n

\u201cCoronaviruses have evolved to require frameshifting as part of their replication cycle to make their proteins.\u201d<\/p>\n\n\n\n

Immunologist Marc Veldhoen<\/a> said in an X Post: \u201cSome well-known anti-vaxers are making claims that the ribosome slip\/frameshift causes a stop codon to be missed and an own mitochondrial protein to be made, risking autoimmunity. It\u00b4s important to know that the mRNA in COVID-19 vaccines do not contain other protein codes.\u201d<\/p>\n\n\n\n

Emergency Physician Kashif Pirzada<\/a> MD said in an X post: \u201cThis is a big deal. Novavax produces much milder reactions in people compared to the mRNA shots, and also presents a more conventional protein-based vaccine option in our polarized information environment. I usually get floored by the mRNA shots, not so with Novavax.\u201d<\/p>\n\n\n\n

Novavax<\/a> is \u201cprobably\u201d the safest COVID-19 vaccine compared to other brands, according to cardiologist Dr. Peter McCullough, who added that he still would not recommend the shot due to high cardiac risks posed by COVID vaccines.<\/p>\n\n\n\n

The three major classes of COVID-19 vaccines are mRNA, vector, and protein subunit vaccines.<\/strong> The Pfizer and Moderna COVID-19 vaccines use mRNA technology, while AstraZeneca and Janssen come under the vector category. Novavax is a protein subunit vaccine.<\/p>\n\n\n\n

There are multiple studies pointing to people suffering from adverse events after being vaccinated.<\/p>\n\n\n\n

An October study<\/a> suggested that COVID-19 vaccines could trigger rheumatic immune-mediated inflammatory diseases that involve inflammation manifesting in the joints, tendons, bones, and muscles due to an unknown cause. This includes conditions like arthritis, vasculitis, lupus, and adult-onset Still’s disease.<\/p>\n\n\n\n

Research has shown<\/a> that COVID-19 mRNA vaccines can reduce a beneficial gut bacteria called Bifidobacteria, the presence of which is associated with higher immunity against pathogens and cancer.<\/p>\n\n\n\n

In a recent interview<\/a> with the \u201cAmerican Thought Leaders” program, clinical pathologist Dr. Ryan Cole said that DNA contamination in some of the mRNA vaccines could be linked to a rising incidence of cancers, micro-clotting, and autoimmune diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"

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