{"id":919,"date":"2021-07-21T18:06:17","date_gmt":"2021-07-21T18:06:17","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=919"},"modified":"2021-07-21T18:06:17","modified_gmt":"2021-07-21T18:06:17","slug":"pathophysiology-of-covid-19-mechanisms-underlying-disease-severity-and-progression","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=919","title":{"rendered":"Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Authors: <a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00019.2020#\">Mary Kathryn Bohn<\/a>,\u00a0<a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00019.2020#\">Alexandra Hall<\/a>,\u00a0<a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00019.2020#\">Lusia Sepiashvili<\/a>,\u00a0<a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00019.2020#\">Benjamin Jung<\/a>,\u00a0<a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00019.2020#\">Shannon Steele<\/a>, and\u00a0<a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00019.2020#\">Khosrow Adeli<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"d19000153e1\">Abstract<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:24px\">The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This review highlights key mechanisms that have been proposed to contribute to COVID-19 progression from viral entry to multisystem organ failure, as well as the central role of the immune response in successful viral clearance or progression to death.<\/p>\n\n\n\n<p class=\"has-large-font-size wp-block-paragraph\">For More Information: <a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00019.2020\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00019.2020<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors: Mary Kathryn Bohn,\u00a0Alexandra Hall,\u00a0Lusia Sepiashvili,\u00a0Benjamin Jung,\u00a0Shannon Steele, and\u00a0Khosrow Adeli Abstract The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":883,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[101,149,155,422],"tags":[],"class_list":["post-919","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","category-epidemiology","category-etiology","category-pathology"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=919"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/919\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/883"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}