{"id":947,"date":"2021-07-21T19:20:01","date_gmt":"2021-07-21T19:20:01","guid":{"rendered":"http:\/\/wp.cov19longhaulfoundation.org\/?p=947"},"modified":"2021-07-21T19:20:01","modified_gmt":"2021-07-21T19:20:01","slug":"clinical-characteristics-of-113-deceased-patients-with-coronavirus-disease-2019-retrospective-study","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=947","title":{"rendered":"Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study"},"content":{"rendered":"\n

Authors: Tao Chen, doctor1<\/a>, \u00a0Di Wu, doctor1<\/a>, \u00a0Huilong Chen, doctor1<\/a>, \u00a0Weiming Yan, research associate1<\/a>, \u00a0Danlei Yang, doctor2<\/a>, \u00a0Guang Chen, doctor1<\/a>, \u00a0Ke Ma, doctor1<\/a>, \u00a0Dong Xu, doctor1<\/a>, \u00a0Haijing Yu, doctor1<\/a>, \u00a0Hongwu Wang, doctor1<\/a>, \u00a0Tao Wang, doctor2<\/a>, \u00a0Wei Guo, doctor1<\/a>, \u00a0Jia Chen, doctor1<\/a>, \u00a0Chen Ding, doctor1<\/a>, \u00a0Xiaoping Zhang, doctor1<\/a>, \u00a0Jiaquan Huang, doctor1<\/a>, \u00a0Meifang Han, doctor1<\/a>, \u00a0Shusheng Li, doctor3<\/a>, \u00a0Xiaoping Luo, doctor4<\/a>, \u00a0Jianping Zhao, doctor2<\/a>, \u00a0Qin Ning, doctor1<\/a><\/p>\n\n\n\n

Among a cohort of 799 patients, 113 who died and 161 who recovered with a diagnosis of covid-19 were analysed. Data were collected until 28 February 2020.<\/p>\n\n\n\n

Main outcome measures<\/strong> Clinical characteristics and laboratory findings were obtained from electronic medical records with data collection forms.<\/p>\n\n\n\n

Results<\/strong> The median age of deceased patients (68 years) was significantly older than recovered patients (51 years). Male sex was more predominant in deceased patients (83; 73%) than in recovered patients (88; 55%). Chronic hypertension and other cardiovascular comorbidities were more frequent among deceased patients (54 (48%) and 16 (14%)) than recovered patients (39 (24%) and 7 (4%)). Dyspnoea, chest tightness, and disorder of consciousness were more common in deceased patients (70 (62%), 55 (49%), and 25 (22%)) than in recovered patients (50 (31%), 48 (30%), and 1 (1%)). The median time from disease onset to death in deceased patients was 16 (interquartile range 12.0-20.0) days. Leukocytosis was present in 56 (50%) patients who died and 6 (4%) who recovered, and lymphopenia was present in 103 (91%) and 76 (47%) respectively. Concentrations of alanine aminotransferase, aspartate aminotransferase, creatinine, creatine kinase, lactate dehydrogenase, cardiac troponin I, N-terminal pro-brain natriuretic peptide, and D-dimer were markedly higher in deceased patients than in recovered patients. Common complications observed more frequently in deceased patients included acute respiratory distress syndrome (113; 100%), type I respiratory failure (18\/35; 51%), sepsis (113; 100%), acute cardiac injury (72\/94; 77%), heart failure (41\/83; 49%), alkalosis (14\/35; 40%), hyperkalaemia (42; 37%), acute kidney injury (28; 25%), and hypoxic encephalopathy (23; 20%). Patients with cardiovascular comorbidity were more likely to develop cardiac complications. Regardless of history of cardiovascular disease, acute cardiac injury and heart failure were more common in deceased patients.<\/p>\n\n\n\n

Conclusion<\/strong>\u00a0Severe acute respiratory syndrome coronavirus 2 infection can cause both pulmonary and systemic inflammation, leading to multi-organ dysfunction in patients at high risk. Acute respiratory distress syndrome and respiratory failure, sepsis, acute cardiac injury, and heart failure were the most common critical complications during exacerbation of covid-19.<\/p>\n\n\n\n

For More Information: https:\/\/www.bmj.com\/content\/368\/bmj.m1091<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Authors: Tao Chen, doctor1, \u00a0Di Wu, doctor1, \u00a0Huilong Chen, doctor1, \u00a0Weiming Yan, research associate1, \u00a0Danlei Yang, doctor2, \u00a0Guang Chen, doctor1, \u00a0Ke Ma, doctor1, \u00a0Dong Xu, doctor1, \u00a0Haijing Yu, doctor1, \u00a0Hongwu […]<\/p>\n","protected":false},"author":2,"featured_media":883,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[101,422],"tags":[],"class_list":["post-947","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","category-pathology"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=947"}],"version-history":[{"count":0,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/947\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/883"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=947"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=947"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}