{"id":9876,"date":"2024-09-04T06:00:00","date_gmt":"2024-09-04T11:00:00","guid":{"rendered":"https:\/\/cov19longhaulfoundation.org\/?p=9876"},"modified":"2024-09-04T15:42:31","modified_gmt":"2024-09-04T19:42:31","slug":"article-navigationarticle-navigation","status":"publish","type":"post","link":"https:\/\/cov19longhaulfoundation.org\/?p=9876","title":{"rendered":"Increased frequency and mortality in persons with neurological disorders during COVID-19\u00a0"},"content":{"rendered":"\n<p class=\"has-small-font-size\">Candace M Marsters,&nbsp;Jeffrey A Bakal,&nbsp;Grace Y Lam,&nbsp;Finlay A McAlister,&nbsp;Christopher Power, <em>Brain<\/em>, awae117,&nbsp;<a href=\"https:\/\/doi.org\/10.1093\/brain\/awae117\">https:\/\/doi.org\/10.1093\/brain\/awae117<\/a>, 20 April 2024<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"464507022\">Abstract<\/h2>\n\n\n\n<p>Determining the frequency and outcomes of neurological disorders associated with coronavirus disease 2019 (COVID-19) is imperative for understanding risks and for recognition of emerging neurological disorders. We investigated the susceptibility and impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among persons with premorbid neurological disorders, in addition to the post-infection incidence of neurological sequelae, in a case\u2013control population-based cohort.<\/p>\n\n\n\n<p>Using health service data collected between 1 March 2020 and 30 June 2021, we constructed a cohort of SARS-CoV-2 RNA-positive (<em>n<\/em>&nbsp;= 177 892) and -negative (<em>n<\/em>&nbsp;= 177 800) adults who were age, sex and comorbidity matched and underwent RT-PCR testing at similar times. COVID-19-associated mortality rates were examined within the cohort. Neurological sequelae were analysed during the acute (&lt;3 months) and the post-acute (3\u20139 months) phases post-infection.<\/p>\n\n\n\n<p>The risk of death was significantly greater in the SARS-CoV-2 RNA-positive (2140 per 100 000 person years) compared with RNA-negative (922 per 100 000 person years) over a follow-up of 9 months, particularly amongst those with premorbid neurological disorders: adjusted odds ratios (95% confidence interval) in persons with a prior history of parkinsonism, 1.65 (1.15\u20132.37); dementia, 1.30 (1.11\u20131.52); seizures, 1.91 (1.26\u20132.87); encephalopathy, 1.82 (1.02\u20133.23); and stroke, 1.74 (1.05\u20132.86). There was also a significantly increased risk for diagnosis of new neurological sequelae during the acute time phase after COVID-19, including encephalopathy, 2.0 (1.10\u20133.64); dementia, 1.36 (1.07\u20131.73); seizure, 1.77 (1.22\u20132.56); and brain fog, 1.96 (1.20\u20133.20). These risks persisted into the post-acute phase after COVID-19, during which inflammatory myopathy (2.57, 1.07\u20136.15) and coma (1.87, 1.22\u20132.87) also became significantly increased.<\/p>\n\n\n\n<p>Thus, persons with SARS-CoV-2 infection and premorbid neurological disorders are at greater risk of death, and SARS-CoV-2 infection was complicated by increased risk of new-onset neurological disorders in both the acute and post-acute phases of COVID-19.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Candace M Marsters,&nbsp;Jeffrey A Bakal,&nbsp;Grace Y Lam,&nbsp;Finlay A McAlister,&nbsp;Christopher Power, Brain, awae117,&nbsp;https:\/\/doi.org\/10.1093\/brain\/awae117, 20 April 2024 Abstract Determining the frequency and outcomes of neurological disorders associated with coronavirus disease 2019 (COVID-19) [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":9878,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58,1037,141,252,264,420],"tags":[],"class_list":["post-9876","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain","category-dementia-2","category-encephalopathy","category-inflammation","category-ischemic-stroke","category-parkinsons-disease"],"_links":{"self":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/9876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9876"}],"version-history":[{"count":3,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/9876\/revisions"}],"predecessor-version":[{"id":10719,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/posts\/9876\/revisions\/10719"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=\/wp\/v2\/media\/9878"}],"wp:attachment":[{"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cov19longhaulfoundation.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}