SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

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aUTHORS: Chien-Ting Wu,1,13Peter V. Lidsky,2,13Yinghong Xiao,2,13Ivan T. Lee,3,4,5,13Ran Cheng,1,6,13Tsuguhisa Nakayama,5,7,13Sizun Jiang,3,13Janos Demeter,1Romina J. Bevacqua,8Charles A. Chang,8,9,10,11Robert L. Whitener,8Anna K. Stalder,12Bokai Zhu,3Han Chen,3 Cell Metab. 2021 Aug 3; 33(8): 1565–1576.e5.Published online 2021 May18. doi: 10.1016/j.cmet.2021.05.013 :  PMC8130512PMID: 34081912 Abstract Emerging evidence points toward an intricate relationship between the pandemic of coronavirus disease 2019 (COVID-19) and diabetes. While preexisting diabetes is […]

The Omicron subvariant BA.2: Birth of a new challenge during the COVID-19 pandemic

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Authors: Farid Rahimia and Amin Talebi Bezmin Abadib,∗ Int J Surg. 2022 Mar; 99: 106261.Published online 2022 Feb12. doi: 10.1016/j.ijsu.2022.106261 PMCID: PMC8837492PMID: 35167986 In November 2021, many patients presented with the atypical pneumonia due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in South Africa [1]. Subsequently, the WHO Technical Advisory Group called Omicron the variant B.1.1.529 which caused the rise […]

ACE2-independent infection of T lymphocytes by SARS-CoV-2

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Authors: Xu-Rui Shen, Rong Geng, Qian Li,  Ying Chen, Shu-Fen Li, Qi Wang, Juan Min, Yong Yang, Bei Li, Yong Yang, Bei Li, Ren-Di Jiang, Xi Wang, Xiao-Shuang Zheng, Yan Zhu, Jing-Kun Jia, Xing-Lou Yang, Mei-Qin Liu, Qian-Chun Gong, Yu-Lan Zhang, Zhen-Qiong Guan, Hui-Ling Li, Zhen-Hua Zheng, Zheng-Li Shi, Hui-Lan Zhang, Ke Peng & Peng Zhou  Signal Transduction and Targeted Therapy volume 7, Article number: 83 (2022)  Abstract SARS-CoV-2 induced marked lymphopenia in severe patients with COVID-19. However, whether lymphocytes are targets of viral infection is […]

11 things doctors have learned about long COVID

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Authors: the UC Davis Post-COVID-19 clinic CORONAVIRUS February 11, 2022 Known to health experts as post-acute sequelae SARS-CoV-2 infection (PASC), it is more commonly known as long-haul COVID or long COVID. The Centers for Disease Control describes post-COVID conditions as ongoing or new symptoms occurring a month or more after a COVID-19 infection. It is estimated that between 10% to 30% of […]

Covid infections in Britain are rising again, and 90 percent of the dead are vaccinated. Have mRNA jabs ruined our chance at herd immunity?

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Authors: Alex Berenson New figures from Britain raise bright red flags about the direction of Covid in wealthy countries that used mRNA and DNA shots to attempt to defeat the coronavirus last year. Hospitalizations and deaths remain stubbornly high and overwhelmingly occur in vaccinated people. In February, 90 percent of the 1,000 Britons who died […]

Baricitinib for patients with severe COVID-19—time to change the standard of care?

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AuthorsAlexander Supadya,c,d and Robert Zeiserb Lancet Respir Med. 2022 Feb 3doi: 10.1016/S2213-2600(22)00021-2 [Epub ahead of print]PMCID: PMC8813061PMID: 35123659 Mortality is high among patients with severe COVID-19 who require invasive mechanical ventilation (IMV) or extracorporeal membrane oxygenation (ECMO).1, 2 Therefore, further specific treatment options for these patients are urgently needed. Early in the COVID-19 pandemic, Janus kinase (JAK) inhibitors were identified as potential therapeutic agents […]

Elevated clotting factor V levels linked to worse outcomes in severe COVID-19 infections

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Authors: Jonathan A. Stefely,Bianca B. Christensen,Tasos Gogakos,Jensyn K. Cone Sullivan … See all authors First published: 24 August 2020 https://doi.org/10.1002/ajh.25979 Abstract Coagulopathy causes morbidity and mortality in patients with coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Yet, the mechanisms are unclear and biomarkers are limited. Early in the pandemic, we observed markedly elevated […]

Nuts and bolts of COVID-19 associated coagulopathy: the essentials for management and treatment

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Authors: Patrick J Lindsay, a Rachel Rosovsky, b Edward A Bittner, c and Marvin G. Chang c ABSTRACT Introduction COVID-19-associated coagulopathy (CAC) is a well-recognized hematologic complication among patients with severe COVID-19 disease, where macro- and micro-thrombosis can lead to multiorgan injury and failure. Major societal guidelines that have published on the management of CAC are based on consensus of expert opinion, with […]

Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series

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Ali Tabatabai 1, Joseph Rabin 2, Jay Menaker 2, Ronson Madathil 3, Samuel Galvagno 4, Ashley Menne 5, Jonathan H Chow 4, Alison Grazioli 6, Daniel Herr 1, Kenichi Tanaka 4, Thomas Scalea 2, Michael Mazzeffi 4Affiliations expand PMID: 32539272 PMCID: PMC7242090 DOI: 10.1213/XAA.0000000000001236 Abstract Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated […]