Category: ACE2 Receptors

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis

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Shin Jie Yong PMID: 33538586 DOI: 10.1021/acschemneuro.0c00793 ACS Chem Neuroscience . 2021 Feb 17;12(4):573-580. doi: 10.1021/acschemneuro.0c00793. Epub 2021 Feb 4. Abstract Long-COVID is a postviral illness that can affect survivors of COVID-19, regardless of initial disease severity or age. Symptoms of long-COVID include fatigue, dyspnea, gastrointestinal and cardiac problems, cognitive impairments, myalgia, and others. While the possible causes of long-COVID include […]

Post-COVID Interstitial Lung Disease—The Tip of the Iceberg

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Namrata Kewalramani, MD,a,b,∗ Kerri-Marie Heenan, MB Bch, BAO,c Denise McKeegan, MB Bch, BAO, MSc,c and Nazia Chaudhuri, MD, PhDd Immunol Allergy Clin North Am. 2023 May; 43(2): 389–410. Published online 2023 Mar3. doi: 10.1016/j.iac.2023.01.004 PMCID: PMC9982726PMID: 37055095 The proportion of symptomatic patients with post-coronavirus 2019 (COVID-19) condition (long COVID) represents a significant burden on the individual as well as on the health care systems. […]

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

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npj Parkinson’s Disease volume 6, Article number: 18 (2020) Cite this article Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson’s disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central […]

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein

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Gerard J Nuovo 1, Cynthia Magro 2, Toni Shaffer 3, Hamdy Awad 4, David Suster 5, Sheridan Mikhail 3, Bing He 2, Jean-Jacques Michaille 6, Benjamin Liechty 2, Esmerina Tili 4 PMID: 33360731 PMCID: PMC7758180DOI: 10.1016/j.anndiagpath.2020.151682 Abstract Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who died of COVID-19 were examined. Cultured endothelial and neuronal cells were incubated with and wild type mice were injected IV with different spike subunits. In […]

In the Eye of the Storm: How Covid-19 Impacts the Eye

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Authors: William A. Haseltine Forbes November 13, 2022 While Covid-19 is commonly associated with infection of the lungs, heart and other vital organs, a growing body of evidence suggests that infection can also impact the eye. Approximately 1 in 10 people exposed to Covid-19 experience at least one eye problem, such as dryness, redness, blurred […]

Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis

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Published:April 20, 2022DOI:https://doi.org/10.1016/j.molmed.2022.04.0 Authors: oannis P. Trougakos Evangelos Terpos Harry Alexopoulos Efstathios Kastritis Evangelos Andreakos Meletios A. Dimopoulos Highlights Coronavirus disease 2019 (COVID-19) mRNA vaccines induce robust immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yet their cellular/molecular mode of action and the etiology of the induced adverse events (AEs) remain elusive. Lipid […]

Less Than 1 In 100 Million Chance That COVID-19 Has Natural Origin

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Authors: Hans Mahncke via The Epoch Times October 24, 2022 A new study on the origins of the pandemic, “Endonuclease fingerprint indicates a synthetic origin of SARS-CoV2,” published on the preprint server bioRxiv, concludes that it is highly likely that the SARS-CoV-2 virus that causes COVID-19 originated in a laboratory. The odds of a natural origin, according to the […]

Coronavirus and blood clots: Causes, effects and treatment

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Authors: Nascimento Pinto MSN The effects of Covid-19 on people are varied but city doctors have observed that there is a possibility of heart attacks, especially in youngsters.  Some city experts say heart attacks after Covid-19 are caused due to the presence of blood clots in the body. However, others believe there is neither any scientific evidence to […]

Understanding COVID-19 through genome-wide association studies

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Authors: Tom H. Karlsen  Nature Genetics volume 54, pages368–369 (2022)Cite this article 8742 Accesses 1 Citations 87 Altmetric Defining the most appropriate phenotypes in genome-wide association studies of COVID-19 is challenging, and two new publications demonstrate how case-control definitions critically determine outcomes and downstream clinical utility of findings. Exploring self-reported data from more than 700,000 participants in a direct-to-consumer ancestry genetics […]

SARS-CoV-2 Infection and the Liver

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Authors: Katie Morgan,1,*Kay Samuel,2Martin Vandeputte,1Peter C. Hayes,1 and John N. Plevris1 Pathogens. 2020 Jun; 9(6): 430.Published online 2020 May 30. doi: 10.3390/pathogens9060430 PMCID: PMC7350360PMID: 32486188 Abstract A novel strain of coronoviridae (SARS-CoV-2) was reported in Wuhan China in December 2019. Initially, infection presented with a broad spectrum of symptoms which typically included muscle aches, fever, dry cough, and shortness of breath. SARS-CoV-2 […]