Category: ACE2 Receptors

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

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Suo-wen Xu, Iqra Ilyas & Jian-ping Weng  Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Cite this article 17 October 2022 Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that […]

COVID-19 Shot May Be Linked To Unexpected Vaginal Bleeding: Study

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THURSDAY, OCT 05, 2023 – 09:20 PM Authored by Mary Gillis The Epoch Times  Norwegian scientists have discovered an unusual side effect in COVID-19-vaccinated women who don’t menstruate: atypical vaginal bleeding after injection with the Moderna and Pfizer vaccines. Researchers studied close to 22,000 women across different reproductive aging stages over about nine months and found […]

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

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Suo-wen Xu, Iqra Ilyas & Jian-ping Weng Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Nature Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by […]

COVID Tongue: How a Swollen Tongue Could Indicate COVID-19

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Should you be examining your tongue? Here’s how to tell if it’s COVID tongue and how to treat it. By  Korin Miller September 22, 2023; Medically reviewed by  Michael Menna, DO HEALTH You may have heard of COVID-19 causing loss of taste and smell, COVID toes, and unusual skin rashes, but did you know COVID can affect […]

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

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David Sulzer, Angelo Antonini, Valentina Leta, Anna Nordvig, Richard J. Smeyne, James E. Goldman, Osama Al-Dalahmah, Luigi Zecca, Alessandro Sette, Luigi Bubacco, Olimpia Meucci, Elena Moro, Ashley S. Harms, Yaqian Xu, Stanley Fahn & K. Ray Chaudhuri  npj Parkinson’s Disease volume 6, Article number: 18 (2020) Cite this article Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus […]

Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: The role of Epstein–Barr virus and the gut–brain axis

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Kenji Hashimoto, Molecular Psychiatry (2023) Published: 04 July 2023 Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public health burden worldwide. In addition to respiratory, heart, and gastrointestinal symptoms, patients infected with SARS-CoV-2 experience a number of persistent neurological and psychiatric symptoms, known as […]

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis

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Shin Jie Yong PMID: 33538586 DOI: 10.1021/acschemneuro.0c00793 ACS Chem Neuroscience . 2021 Feb 17;12(4):573-580. doi: 10.1021/acschemneuro.0c00793. Epub 2021 Feb 4. Abstract Long-COVID is a postviral illness that can affect survivors of COVID-19, regardless of initial disease severity or age. Symptoms of long-COVID include fatigue, dyspnea, gastrointestinal and cardiac problems, cognitive impairments, myalgia, and others. While the possible causes of long-COVID include […]

Post-COVID Interstitial Lung Disease—The Tip of the Iceberg

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Namrata Kewalramani, MD,a,b,∗ Kerri-Marie Heenan, MB Bch, BAO,c Denise McKeegan, MB Bch, BAO, MSc,c and Nazia Chaudhuri, MD, PhDd Immunol Allergy Clin North Am. 2023 May; 43(2): 389–410. Published online 2023 Mar3. doi: 10.1016/j.iac.2023.01.004 PMCID: PMC9982726PMID: 37055095 The proportion of symptomatic patients with post-coronavirus 2019 (COVID-19) condition (long COVID) represents a significant burden on the individual as well as on the health care systems. […]

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

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npj Parkinson’s Disease volume 6, Article number: 18 (2020) Cite this article Abstract This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson’s disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central […]

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein

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Gerard J Nuovo 1, Cynthia Magro 2, Toni Shaffer 3, Hamdy Awad 4, David Suster 5, Sheridan Mikhail 3, Bing He 2, Jean-Jacques Michaille 6, Benjamin Liechty 2, Esmerina Tili 4 PMID: 33360731 PMCID: PMC7758180DOI: 10.1016/j.anndiagpath.2020.151682 Abstract Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who died of COVID-19 were examined. Cultured endothelial and neuronal cells were incubated with and wild type mice were injected IV with different spike subunits. In […]