Category: Epithelium

Three years on, COVID-19 and the skin: long-term impacts, emerging trends and clinical practice 

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Esther E Freeman, Ignacio Garcia-Doval, Luigi Naldi, Roderick J Hay British Journal of Dermatology, Volume 189, Issue 1, July 2023, Pages 1–, https://doi.org/10.1093/bjd/ljad131 In early 2020 there were reports of a new and potentially fatal viral infection affecting large numbers of people in Wuhan, China. Over the following 3 months it had spread throughout most of the world, with all countries […]

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo

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Shreya Ghimire, Biyun Xue, Kun Li, Ryan M Gannon, et. al.doi: https://doi.org/10.1101/2024.07.03.60194 Abstract Treatments available to prevent progression of virus-induced lung diseases, including coronavirus disease 2019 (COVID-19) are of limited benefit once respiratory failure occurs. The efficacy of approved and emerging cytokine signaling-modulating antibodies is variable and is affected by disease course and patient-specific inflammation patterns. Therefore, understanding the role of inflammation on the […]

SARS-CoV-2 particles promote airway epithelial differentiation and ciliation

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Julian Gonzalez-Rubio1 Vu Thuy Khanh Le-Trilling2 Lea Baumann1 Maria Cheremkhina1 Hannah Kubiza1 Anja E. Luengen1,3 Sebastian Reuter3 Christian Taube3 Stephan Ruetten4 Daniela Duarte Campos5 Christian G. Cornelissen1,6 Mirko Trilling2 Anja Lena Thiebes1, Front. Bioeng. Biotechnol., 02 November 2023 Sec. Tissue Engineering and Regenerative MedicineVolume 11 – 2023 | https://doi.org/10.3389/fbioe.2023.1268782 Introduction: The Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which caused the coronavirus disease 2019 (COVID-19) pandemic, enters the […]

SARS-CoV-2 particles promote airway epithelial differentiation and ciliation

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Julian Gonzalez-Rubio1* Vu Thuy Khanh Le-Trilling2 Lea Baumann1 Maria Cheremkhina1 Hannah Kubiza1 Anja E. Luengen1, 3 Sebastian Reuter3 Christian Taube3 Stephan Ruetten4 Daniela Duarte Campos5 Christian Cornelissen6 Mirko Trilling2 Anja Lena Thiebes1* Front. Bioeng. Biotechnology. , Sec. Tissue Engineering and Regenerative Medicine, Volume 11 – 2023 | doi: 10.3389/fbioe.2023.1268782 The Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which caused the coronavirus disease 2019 (COVID-19) pandemic, enters the […]

Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: The role of Epstein–Barr virus and the gut–brain axis

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Kenji Hashimoto, Molecular Psychiatry (2023) Published: 04 July 2023 Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public health burden worldwide. In addition to respiratory, heart, and gastrointestinal symptoms, patients infected with SARS-CoV-2 experience a number of persistent neurological and psychiatric symptoms, known as […]

Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives

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Authors: Giovanni Genovese,a,bChiara Moltrasio,a,cEmilio Berti,a,b and Angelo Valerio Marzanoa,b,* Dermatology. 2020 Nov 24 : 1–12.Published online 2020 Nov 24. doi: 10.1159/000512932PMCID: PMC7801998PMID: 33232965 Abstract Background Coronavirus disease-19 (COVID-19) is an ongoing global pandemic caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), which was isolated for the first time in Wuhan (China) in December 2019. Common symptoms include fever, cough, fatigue, […]

Pathophysiology of COVID-19:

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Mechanisms Underlying Disease Severity and Progression Authors: Mary Kathryn Bohn,1,2, Alexandra Hall,1 Lusia Sepiashvili,1,2, Benjamin Jung,1,2 Shannon, Steele,1 and Khosrow Adeli1,2,3 The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the […]

The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

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Authors:Jenny K.Stodola1GuillaumeDubois1AlainLe CoupanecMarcDesforgesPierre J.Talbot Highlights Coronavirus structural envelope (E) protein specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation are needed for optimal production of recombinant infectious virus.• Fully functional E protein of HCoV-OC43 is crucial for viral propagation in the CNS and neurovirulence.• Fully functional E protein of HCoV-OC43 is crucial […]

Pathological findings in organs and tissues of patients with COVID-19: A systematic review

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Authors: Sasha Peiris, Hector Mesa, Agnes Aysola, Juan Manivel, Joao Toledo, Marcio Borges-Sa, Sylvain Aldighieri, Ludovic Reveiz Abstract Background Coronavirus disease (COVID-19) is the pandemic caused by SARS-CoV-2 that has caused more than 2.2 million deaths worldwide. We summarize the reported pathologic findings on biopsy and autopsy in patients with severe/fatal COVID-19 and documented the […]

SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids

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Authors: Laura Pellegrini 1, Anna Albecka 1, Donna L Mallery 1, Max J Kellner 1, David Paul 1, Andrew P Carter 1, Leo C James 1, Madeline A Lancaster 2 Abstract Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be fatal. However, neurological symptoms have also been observed in some patients. The cause of these complications is […]