Background John Murphy, CEO COV-19 Long-haul Foundation Persistent dermatologic manifestations represent an increasingly recognized component of post-acute sequelae of SARS-CoV-2 infection (PASC), commonly termed Long COVID. Among these manifestations, chronic […]
1. Core Mechanisms Behind Skin and Vessel Injury in COVID-19
John Murphy, CEO COVID Long-haul Foundation A. Endothelial injury (central mechanism) COVID-19 directly infects or injures endothelial cells via ACE2 receptors. This leads to: This is the foundation for both […]
Skin Defects & Long COVID: Etiology, Pathophysiology, Clinical Progression, and Therapeutic Strategies
Abstract John Murphy, M.D., M.P.H., D.P.H., President The Covid-19 Long-haul Foundation Long COVID, also termed post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a chronic multisystem disorder affecting millions […]
SARS-CoV-2 Infection of Human Epithelial Tissues
John Murphy, CEO The COVID-19 Long-haul Foundation Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), is a pleiotropic pathogen with profound effects […]
SARS-CoV-2–Associated Injury to Human Epithelial Tissues
Authors: John Murphy, M.D., MPH, DPH. ,Affiliations: President COVID-19 Long-haul FoundationAbstract: 250 words Abstract BackgroundSARS-CoV-2 infection produces multisystem disease with prominent epithelial involvement extending beyond the respiratory tract. Increasing evidence […]
COVID-19 and the Etiology of Skin Breakdown: Genomic Mechanisms, Clinical Diagnosis, Variations, Treatment, and Outcomes
The global impact of COVID-19 has extended far beyond its respiratory origins, revealing a complex spectrum of systemic manifestations. Among these, dermatologic involvement has emerged as both a diagnostic clue […]
Cutaneous Consequences of COVID-19: Disruption of the Dermis, Epidermis, and Vascular Matrix
John Murphy, The COVID 19 Long-haul Foundation Abstract SARS-CoV-2, the virus responsible for COVID-19, is primarily known for its respiratory and systemic effects. However, its impact on the skin—particularly the […]
Nails and COVID‐19 – A comprehensive review of clinical findings and treatment
Uwe Wollina 1,✉, Jean Kanitakis 2, Robert Baran 3, PMCID: PMC8420555 PMID: 34398500 Abstract The SARS‐CoV‐2 infection, responsible for COVID‐19, has raised the interest for infection‐associated muco‐cutaneous symptoms. While dermatologic symptoms in general gained an increasing awareness, […]
Unveiling the Connections Between Melanoma Differentiation-Associated Gene 5 (MDA5)-Positive Dermatomyositis and Its Potential Association With COVID-19: A Report of Two Cases
Temitope B. Abegunde • Christophe Persad • Sojibuchi Ojule • Jane Colgan • Margaret Duncan, 2024DOI: 10.7759/cureus.65016 Abstract Dermatomyositis is a rare inflammatory condition affecting the skin, muscles, and joints. This series of anti-melanoma differentiation-associated gene 5 (anti-MDA5) autoantibody-positive […]
Three years on, COVID-19 and the skin: long-term impacts, emerging trends and clinical practice
Esther E Freeman, Ignacio Garcia-Doval, Luigi Naldi, Roderick J Hay British Journal of Dermatology, Volume 189, Issue 1, July 2023, Pages 1–, https://doi.org/10.1093/bjd/ljad131 In early 2020 there were reports of a new and potentially fatal […]