Long COVID and Dysautonomia: Emerging Insights Into Autonomic Dysfunction, Vagal Pathobiology, Neuroimmune Interactions, and Therapeutic Strategies

John Murphy, M.D., M.P.H., D.P.H. CEO COVID Long-haul Foundation Abstract Background Long COVID, also termed Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), is a complex multisystem disorder characterized by persistent symptoms […]

Actigraphy / Circadian Rhythm / Depression & Mental Health / Endocrine contributors / Idiopathic Hypersomnia / Narcolepsy / Parasomnias / Polysomnography / Psychiatric Disorders / Restless Legs Syndrome / Sleep & Dreams / Sleep Disturbance / Sleep Latency / Sleep-Wake Disorders Posted on: July 24, 2026July 8, 2026

Sleep Disorders: Etiology, Physiology, Pathology, Clinical Presentation, Diagnostics, Differential Diagnosis, Treatment, and Long-Term Outcomes

A Comprehensive Clinical and Neurobiological Review john Murphy, CEO, The COVID-19 Long-haul Foundation Abstract Sleep disorders comprise a heterogeneous group of conditions characterized by disruption of sleep quantity, quality, timing, […]

Anxiety / Circadian Rhythm / Cognitive deficit / Depression & Mental Health / Fatigue / Inflammation / Mitochondria / Neurologic Effects / PASC / Sleep & Dreams / Sleep Deprivation / Sleep Disturbance Posted on: July 11, 2026June 23, 2026

Long COVID and Sleep Disorders: An Emerging Biologic Nexus in Post-Acute Sequelae of SARS-CoV-2 Infection

John Murphy, CEO, COVID-19 Long-haul Foundation Abstract Sleep disturbance has emerged as one of the most prevalent, persistent, and disabling manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), commonly known […]

Cognitive deficit / Cognitive Deficits / Dysautonomia / Dyspnea / Fatigue / Pain / Postural Orthostatic Tachycardia (POTS) / Sleep Disturbance / Tachycardia / Vagus Nerve Posted on: July 9, 2026June 25, 2026

Long COVID and Dysautonomia

John Murphy, M.D., M.P.H., D.P.H., President, The COVID-19 Lonh-haul Foundation Abstract: Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) is increasingly recognized as a heterogeneous syndrome characterized by persistent fatigue, […]

Brain Fog / Epidemiology / Omicron / Prevalence / Shortness of Breath / Sleep Disturbance / Smell & Taste / Taste & Smell Posted on: April 28, 2026April 17, 2026

Long-COVID prevalence may vary by COVID-19 variant, time since infection

Mary Van Beusekom, MS The first known meta-analysis of how SARS-CoV-2 variant type and time since infection influence long-COVID symptoms ties Omicron to brain fog and paresthesia (numbness and tingling), while earlier […]

Cognitive deficit / MECFS / Orthostatic intolerance / PASC / Sleep Disturbance Posted on: February 22, 2026January 24, 2026

Overlapping Clinical Presentation of Long COVID and Postacute COVID-19 Vaccination Syndrome

Lawrence Purpura , Thomas Heisler , Steven Palmer , et. al. linical Infectious Diseases, ciaf624, https://doi.org/10.1093/cid/ciaf62 Abstract Background Postacute sequelae of COVID-19 (PASC), also known as long COVID, and postacute COVID-19 vaccination syndrome (PACVS) present overlapping but […]

Sleep & Dreams / Sleep Deprivation / Sleep Disturbance Posted on: January 21, 2026November 20, 2025

Post-Acute Sequelae of SARS-CoV-2 Infection: Sleep Disturbances in Long COVID

John Murphy, CEO, The COVID-19 Long-haul Foundation Abstract Sleep disturbances have emerged as one of the most persistent and debilitating manifestations of Post-Acute Sequelae of SARS-CoV-2 infection (PASC), commonly referred […]

Melatonin / Sleep & Dreams / Sleep Disturbance / Treatments Posted on: October 25, 2025October 13, 2025

Title: Melatonin as a Therapeutic Agent in Long COVID Sleep Disorders: A Multidimensional Review

John Murphy, The Covid-19 Long haul Foundation Abstract Sleep disturbances have emerged as one of the most persistent and debilitating symptoms of Long COVID, affecting up to 76% of patients […]

Apnea / Sleep Deprivation / Sleep Disturbance Posted on: October 18, 2025October 12, 2025

🧠 Association Between Long COVID and Sleep Apnea

🔗 Key Findings from NIH RECOVER Initiative 📊 Epidemiology Population Group OSA Prevalence Long COVID Risk Increase Adults (N3C) ~5% +75% Adults (PCORnet) ~5% +12% Children <2% No significant increase […]

Apnea / Insomnia / Narcolepsy / PASC / Sleep & Dreams / Sleep Disturbance Posted on: September 26, 2025June 17, 2025

Severe persistent specific sleep disorders in post-acute sequelae of SARS-CoV-2 Free

Richard Czuma , Robert Thomas , Jason Maley , Danielle Gott, Sleep, Volume 46, Issue Supplement_1,, https://doi.org/10.1093/sleep/zsad077.0969 Abstract Introduction Viral infections have long been associated with sleep disorders, especially hypersomnia following the acute phase The Covid-19 epidemic […]