Authors: Mary Kathryn Bohn, Alexandra Hall, Lusia Sepiashvili, Benjamin Jung, Shannon Steele, and Khosrow Adeli

Abstract

The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This review highlights key mechanisms that have been proposed to contribute to COVID-19 progression from viral entry to multisystem organ failure, as well as the central role of the immune response in successful viral clearance or progression to death.

For More Information: https://journals.physiology.org/doi/full/10.1152/physiol.00019.2020