Intranasal Chlorpheniramine for Early Symptomatic Treatment of COVID-19 and the Impact on Long-COVID

June 25, 2025 | John Murphy | Leave a Comment

Intranasal Chlorpheniramine for Early Symptomatic Treatment of COVID-19 and the Impact on Long-COVID

Gustavo Ferrer • Fernando Valerio-Pascua • César Alas-Pineda • et.al., DOI: 10.7759/cureus.82736 Abstract This review explores the therapeutic potential of intranasal chlorpheniramine maleate (iCPM) in managing both acute COVID-19 and Long COVID by integrating histamine H1 receptor…[...]

March 5, 2025 | John Murphy | Leave a Comment

CD56+ Monocytes and CD31+ Endothelial Cells Are Increased in Severe COVID-19 Disease

Abstract Immune response dysregulation plays a key role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. In this study, we evaluated immune and endothelial blood cell profiles of patients…[...]

February 14, 2025 | John Murphy | Leave a Comment

A Systematic Review of Case Reports of New-Onset Atrial Fibrillation in COVID-19 Patients

Rocio Barriga Guzman • Oluwaremilekun Tolu-Akinnawo • Toluwalase Awoyemi • et. al DOI: 10.7759/cureus.78938 Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic posed a significant global public health challenge, affecting millions of individuals. While some…[...]

February 9, 2025 | John Murphy | Leave a Comment

How COVID-19 Affects the Brain

Maura Boldrini, MD, PhD1,2; Peter D. Canoll, MD, PhD3; Robyn S. Klein, MD, PhD4,5,6, JAMA Psychiatry. 2021;78(6):682-683. doi:10.1001/jamapsychiatry.2021.0500 COVID-19 has resulted in more than 120 million cases and 2.6 million deaths to date. Respiratory and gastrointestinal symptoms are accompanied…[...]

January 23, 2025 | John Murphy | Leave a Comment

Long Covid: Hormone Imbalances and/or Rather Complex Immune Dysregulations?

Christian A Koch, Journal of the Endocrine Society, Volume 8, Issue 5, May 2024, bvae043, https://doi.org/10.1210/jendso/bvae043 Approximately 5% of all individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do…[...]

January 22, 2025 | John Murphy | Leave a Comment

Long Covid explanation in new study possibly paves way for tests and treatments

By Barbara Mantel, NBC News Scientists say that drugs that calm a key part of the immune system should be studied in clinical trials as potential long Covid treatments. Scientists have…[...]

December 11, 2024 | John Murphy | Leave a Comment

Severe Coronary Vasospasms in Asymptomatic COVID-19

Omar M. Masarweh • Ubaldo Gonzalez-Morales • Sara Tahir • Sana Tahir • Sayed T. Hussain, 2024, DOI: 10.7759/cureus.64869 Abstract Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, we have witnessed its multi-organ…[...]

December 10, 2024 | John Murphy | Leave a Comment

A Unique Case of Unprovoked Pulmonary Venous Thrombosis in a Postpartum Female Following COVID-19 Infection

Jordan Lipschutz • Sophia H. Ji • Mohammad Q. Jafri • Ambica Nair • Brian Kerr, 2024, DOI: 10.7759/cureus.64893 Abstract SARS-CoV-2 can induce a hypercoagulable state, occasionally resulting in pulmonary venous thrombosis (PVT) due to inflammation and endothelial injury.…[...]

November 1, 2024 | John Murphy | Leave a Comment

Endothelial cell damage is the central part of COVID-19 and a mouse model
induced by injection of the S1 subunit of the spike protein

Authors: Gerard J. NuovoCynthia MagroToni ShafferHamdy AwadDavid SusterSheridan MikhailBing HeJean-Jacques MichailleBenjamin LiechtyEsmerina Tili Annals of Diagnostic Pathology ABS T R A C TNeurologic complications of symptomatic COVID-19 are common. Brain…[...]

October 14, 2024 | John Murphy | Leave a Comment

Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19

Carlos Garcia-Prieto, Eva Musulen, Veronica Davalos, et. al.doi: https://doi.org/10.1101/2024.07.03.601404 00010010 Abstract Severe Coronavirus disease 2019 (COVID-19) induces heterogeneous and progressive diffuse alveolar damage (DAD) highly disrupting lung tissue architecture and homeostasis, hampering disease management and leading to…[...]