Category: Endothelium

Endothelial cell damage is the central part of COVID-19 and a mouse model
induced by injection of the S1 subunit of the spike protein

Posted on | Posted on John Murphy | Leave a Comment on Endothelial cell damage is the central part of COVID-19 and a mouse model<br>induced by injection of the S1 subunit of the spike protein

Authors: Gerard J. NuovoCynthia MagroToni ShafferHamdy AwadDavid SusterSheridan MikhailBing HeJean-Jacques MichailleBenjamin LiechtyEsmerina Tili Annals of Diagnostic Pathology ABS T R A C TNeurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who died of COVID-19 were examined. Cultured endothelial and neuronal cells were incubated with and wild type mice were […]

Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19

Carlos Garcia-Prieto, Eva Musulen, Veronica Davalos,  et. al.doi: https://doi.org/10.1101/2024.07.03.601404 00010010 Abstract Severe Coronavirus disease 2019 (COVID-19) induces heterogeneous and progressive diffuse alveolar damage (DAD) highly disrupting lung tissue architecture and homeostasis, hampering disease management and leading to fatal outcomes. Characterizing DAD pathophysiology across disease progression is of ultimate importance to better understand the molecular and cellular features driving different DAD patterns and […]

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

Authors: Luca Perico1†, Marina Morigi1†, Miriam Galbusera1, et. al. Frontiers in Immunology March 2922 Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability of SARS-CoV-2 to infect and replicate in endothelial cells, it has been poorly investigated whether, in the complexity of viral infection in […]

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

Posted on | Posted on John Murphy | Leave a Comment on SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

Authors: Luca Perico 1, Marina Morigi 1, et. al.; 2022 Mar 7;13:827146. doi: 10.3389/fimmu. 2022.827146. eCollection 2022. Abstract Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability of SARS-CoV-2 to infect and replicate in endothelial cells, it has been poorly investigated whether, in the complexity of viral […]

Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

Posted on | Posted on John Murphy | Leave a Comment on Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

James May, Jane A. Mitchell, and R. Gisli Jenkins, Published September 15, 2023 – 10.1172/JCI172058 Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and mortality of IPF are rising, but treatment remains limited. Currently, two drugs can slow the scarring process but often at the expense of intolerable side […]

Brain Injuries After COVID Vaccination

Posted on | Posted on John Murphy | Leave a Comment on Brain Injuries After COVID Vaccination

Colleen Huber    April 12, 2023 HEALTH VIEWPOINTS, There are back door routes to the brain. COVID vaccine developers have traversed a path through those doors. And they knew they had entered the brain by November 2020, before the vaccine rollout. We have 86 billion neurons in the human brain, and each of those connects with […]

Treatment of Long COVID symptoms with triple anticoagulant therapy

Posted on | Posted on John Murphy | Leave a Comment on Treatment of Long COVID symptoms with triple anticoagulant therapy

Gert J Laubscher, M Asad Khan, Chantelle Venter, Jan H Pretorius, and 2 more, This is a preprint; it has not been peer reviewed by a journal. https://doi.org/10.21203/rs.3.rs-2697680/v1 Research Square Abstract Background: Fibrin(ogen) amyloid microclots and platelet hyperactivation are key pathological findings in patients with acute COVID-19 infection and also in those with Long COVID/Post-Acute Sequelae […]

Unraveling long COVID: Here’s what scientists who study the illness want to find out

Posted on | Posted on John Murphy | Leave a Comment on Unraveling long COVID: Here’s what scientists who study the illness want to find out

September 9, 2023, By Will Stone NPR Newsletter Researchers looking for root causes of long COVID work in the autopsy suite inside the Clinical Center at the National Institute of Health in Bethesda, Maryland. Valerie Plesch/Bloomberg via Getty Images For people suffering from long COVID’s often disabling symptoms, including intense fatigue, breathing troubles, cognitive issues and heart […]

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Posted on | Posted on John Murphy | Leave a Comment on Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Suo-wen Xu, Iqra Ilyas & Jian-ping Weng  Acta Pharmacologica Sinica volume 44, pages695–709 (2023) Cite this article 17 October 2022 Abstract The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. Endothelial cells are sentinels lining the innermost layer of blood vessel that […]

Long COVID scientists try to unravel blood clot mystery

Posted on | Posted on John Murphy | Leave a Comment on Long COVID scientists try to unravel blood clot mystery

May 15, 202312:15 AM ET By Anil Oza, Rebecca Ramirez, Emily Kwong, Gabriel Spitzer, Margaret Cirino, Berly McCoy, https://www.npr.org/2023/05/10/1175217130/long-covid-scientists-try-to-unravel-blood-clot-mystery As part of studying long COVID, graduate researcher Bradley Wade Hamilton separates out microclots from blood platelets in a solution. The federal COVID-19 public health emergency ended last week, but millions in the U.S. — and across the globe — are still dealing […]