Acute tubular injury (ATI) / Concerns / Diabetes / Diabetes Insipidus / Endothelial injury / Endothelium / Kidney / Kidney dysfunction / Mortality / Mortality & Morbidity / Pathology / Thrombotic microangiopathy / Vaccine Failure / Vaccine News / Vaccine Safety Posted on:

Renal Injury After COVID-19 Vaccination: Recommendations for Pathologists and Clinicians

John Murphy, CEO The COVID-19 Long haul Foundation Abstract The global deployment of SARS-CoV-2 vaccines has been accompanied by reports of acute kidney injury (AKI), glomerular disease, interstitial nephritis, podocytopathy […]

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Autonomic nervous system disruption / Diagnosis / Diagnostic Framework / Diagnostic Test / Diagnostics / Dysautonomia / Endothelial Dysfunction / Endothelium / Epidemiology / Hormonal Dysregulation / Metabolic Dysregulation / Microvascular damage / Microvascular injury / Mitochondria / Mitochondrial dysfunction / Multidisciplinary Care Pathways / Multisystem Disease / Neuroinflammation / Occupational Therapy / Pathobiological / Physical Therapy / Postural Orthostatic Tachycardia (POTS) / Sleep Disturbance / Systems-Based Model / T-cell / Treatments / Viral persistence Posted on:

Multidisciplinary Care Pathways for Long COVID Fatigue:

A Systems-Based Model Integrating Rehabilitation Medicine, Neuroimmunology, Autonomic Care, and Precision Phenotyping Abstract Background Long COVID, also referred to as post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as one […]

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Autonomic nerves / Autonomic nervous system disruption / Central autonomic network / CNS / Dysautonomia / Endothelium / Etiology / Gastrointestinal / Immune Modulators / Immune System / Immunopathology / Mitochondrial depletion / Orthostatic intolerance / Outcomes / Pathology / Pathophysiology / Postural Orthostatic Tachycardia (POTS) / Sleep Disturbance / Tachycardia / Temperature / Treatments / Vagus Nerve Posted on:

Long COVID and Dysautonomia: Emerging Insights Into Autonomic Dysfunction, Vagal Pathobiology, Neuroimmune Interactions, and Therapeutic Strategies

John Murphy, M.D., M.P.H., D.P.H. CEO COVID Long-haul Foundation Abstract Background Long COVID, also termed Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), is a complex multisystem disorder characterized by persistent symptoms […]

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Clots & Bleeds / Endothelium / Hyperinflammation / Inflammasome / Inflammation / ME/CFS / Nitric oxide Posted on:

Long COVID and Vascular Injury in 2026: Emerging Evidence for Endothelial Dysfunction, Microvascular Disease, and Persistent Immunothrombotic Pathology

John Murphy, M.D., M.P.H., D.P.H. President COVID-19 Long-haul Foundation Abstract Long COVID, also termed post-COVID condition or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as one of the most […]

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Autonomic nervous system disruption / Clinical Trials / Cognitive deficit / Cognitive Deficits / Endothelium / Immune dysregulation / Immunity / Metabonomics / Neurologic Effects / Neuropathy / Recover / Treatments Posted on:

NIH RECOVER Clinical Trials and the First Emergence of Interventional Results in Long COVID Research: A Translational Turning Point

A Scholarly Review for Scientific American (Submission-Style Manuscript) John Murphy, M.D., M.P.H., D.P.H., President, COVID-19 Long-Haul Foundation Abstract The NIH RECOVER Initiative represents the largest coordinated research program investigating post–acute […]

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Brain Fog / Endothelium / Exercise Intolerance / Fatigue / Immune System / Long COV / Long-haul Disease / Mitochondria / Mitochondrial dysfunction / Palpitations / PASC / Post-infectious Syndrome / T-cell Posted on:

Recognition of Long COVID as a Heterogeneous Post-Infectious Syndrome

Toward a Multisystem Endotype Framework for Post–Acute SARS-CoV-2 Disease John Murphy, M.D., M.P.H., D.P.H. President Covid-19 Long-haul Foundation Abstract Long COVID (post–acute sequelae of SARS-CoV-2 infection, PASC) has emerged as […]

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Dysautonomia / Endothelium / Immune System / Inflammation / Mitochondria / Mitochondrial dysfunction / Mitochondrial Effects / Treatments Posted on:

Treatment Landscape in Long COVID Has Expanded Beyond “Supportive Care”

A Mechanism-Driven Reframing of Therapeutic Development in Post–Acute SARS-CoV-2 Disease John Murphy, M.D, M.P.H., D.P.H. President COVID Long-haul Foundation Conceptual Shift and Therapeutic Reclassification ABSTRACT For much of the early […]

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Autonomic nervous system disruption / Brain / Cognitive deficit / Cytokine Storm / Endothelium / Fatigue / Hyperinflammation / Inflammasome / Inflammation / Inflammation / Microvascular damage / Mitochondria / Mitochondrial dysfunction / Mitochondrial Effects / Neuropathy Posted on:

Persistent Viral Reservoirs and Immune Dysregulation in Long COVID

John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]

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