Category: Endothelium

Posted on | Posted on John Murphy | Leave a Comment on Diagnostic Biomarkers and Imaging Modalities in Long COVID: Toward Precision Detection and Monitoring

Diagnostic Biomarkers and Imaging Modalities in Long COVID: Toward Precision Detection and Monitoring

Author: John Murphy, President, COVID-19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), presents with a complex array of symptoms affecting multiple organ systems. Accurate diagnosis…[...]

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Posted on | Posted on John Murphy | 2 Comments on Therapeutic Strategies and Clinical Trials in Long COVID: Anticoagulants, Fibrinolytics, Endothelial Support, Immunomodulators, and RECOVER Protocols

Therapeutic Strategies and Clinical Trials in Long COVID: Anticoagulants, Fibrinolytics, Endothelial Support, Immunomodulators, and RECOVER Protocols

Author: John Murphy, President, COVID-19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is a chronic multisystem condition affecting millions globally. Despite its prevalence, therapeutic options…[...]

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Posted on | Posted on John Murphy | Leave a Comment on Endothelial Dysfunction and Spike Protein Persistence in Long COVID: Mechanisms, Vulnerabilities, and Clinical Evidence

Endothelial Dysfunction and Spike Protein Persistence in Long COVID: Mechanisms, Vulnerabilities, and Clinical Evidence

Author: John Murphy, President, COVID-19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is characterized by persistent symptoms affecting multiple organ systems. Among its most compelling…[...]

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Posted on | Posted on John Murphy | Leave a Comment on The SARS-CoV-2 Spike Protein: Architecture, Binding Dynamics, and Clearance Evolution Over Five Years

The SARS-CoV-2 Spike Protein: Architecture, Binding Dynamics, and Clearance Evolution Over Five Years

John Murphy, President The COVID Long-haul Foundation Abstract The SARS-CoV-2 spike (S) protein is the principal mediator of viral entry and a key determinant of COVID-19 pathogenesis. This article provides…[...]

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Posted on | Posted on John Murphy | Leave a Comment on Long Covid: Hormone Imbalances and/or Rather Complex Immune Dysregulations? 

Long Covid: Hormone Imbalances and/or Rather Complex Immune Dysregulations? 

Christian A Koch, Journal of the Endocrine Society, Volume 8, Issue 5, May 2024, bvae043, https://doi.org/10.1210/jendso/bvae043  Commentary Approximately 5% of all individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…[...]

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Posted on | Posted on John Murphy | Leave a Comment on 🩸 COVID-19 and Chronic Venous Insufficiency: 2025 Research Insights on Etiology, Vascular Damage, and Treatment

🩸 COVID-19 and Chronic Venous Insufficiency: 2025 Research Insights on Etiology, Vascular Damage, and Treatment

Chronic Venous Insufficiency (CVI)—a condition where leg veins fail to return blood efficiently to the heart—has gained renewed attention in 2025 due to its association with COVID-19, particularly in patients…[...]

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Posted on | Posted on John Murphy | Leave a Comment on Intranasal Chlorpheniramine for Early Symptomatic Treatment of COVID-19 and the Impact on Long-COVID

Intranasal Chlorpheniramine for Early Symptomatic Treatment of COVID-19 and the Impact on Long-COVID

Gustavo Ferrer • Fernando Valerio-Pascua • César Alas-Pineda • et.al., DOI: 10.7759/cureus.82736  Abstract This review explores the therapeutic potential of intranasal chlorpheniramine maleate (iCPM) in managing both acute COVID-19 and Long COVID by integrating histamine H1 receptor…[...]

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