A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice


Jide Tian1*Barbara J. Dillion2Jill Henley3et. al. Gamma-aminobutyric acid (GABA) and GABA-receptors (GABA-Rs) form a major neurotransmitter system in the brain. GABA-Rs are also expressed by 1) cells of the innate…[...]

Postacute Sequelae of SARS-CoV-2 Infection in the Pre-Delta, Delta, and Omicron Eras


Authors: Yan Xie, Ph.D. https://orcid.org/0000-0002-2457-9382, Taeyoung Choi, M.S., and Ziyad Al-Aly, M.D. https://orcid.org/0000-0002-2600-0434, N Engl J Med 2024;391:515-525, DOI: 10.1056/NEJMoa2403211, VOL. 391 NO. 6 Abstract Background Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) can affect many organ systems. However, temporal…[...]

Efficacy and safety of hyperbaric oxygen therapy for long COVID: a protocol for systematic review and meta-analysis


Yuxin Li, Jingnan Lin, Jiazhu Gao et. al., http://orcid.org/0009-0000-2874-1861 Abstract Introduction There is still a lack of therapeutic options for long COVID. Several studies have shown the benefit of hyperbaric oxygen therapy (HBOT) on…[...]

Endothelial cell damage is the central part of COVID-19 and a mouse model
induced by injection of the S1 subunit of the spike protein


Authors: Gerard J. NuovoCynthia MagroToni ShafferHamdy AwadDavid SusterSheridan MikhailBing HeJean-Jacques MichailleBenjamin LiechtyEsmerina Tili Annals of Diagnostic Pathology ABS T R A C TNeurologic complications of symptomatic COVID-19 are common. Brain…[...]

Three years on, COVID-19 and the skin: long-term impacts, emerging trends and clinical practice 


Esther E Freeman, Ignacio Garcia-Doval, Luigi Naldi, Roderick J Hay British Journal of Dermatology, Volume 189, Issue 1, July 2023, Pages 1–, https://doi.org/10.1093/bjd/ljad131 In early 2020 there were reports of a new and potentially fatal…[...]

Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19


Carlos Garcia-Prieto, Eva Musulen, Veronica Davalos,  et. al.doi: https://doi.org/10.1101/2024.07.03.601404 00010010 Abstract Severe Coronavirus disease 2019 (COVID-19) induces heterogeneous and progressive diffuse alveolar damage (DAD) highly disrupting lung tissue architecture and homeostasis, hampering disease management and leading to…[...]