Study points to vagus nerve dysfunction as a central pathophysiological feature of long COVID

by Emily Henderson, B.Sc.Feb 2022 News Medical Life Sciences New research to be presented at this year’s European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2022, Lisbon, 23-26 April) suggests that many of the symptoms connected to post-COVID syndrome (PCC, also known as long COVID) could be linked to the effect of the virus on […]

COVID-19 Can Remain Undetected In Lungs For 18 Months: Study

DEC 14, 2023 – Authored by Amie Dahnke via The Epoch Times  The COVID-19 virus can remain in the lungs for months after an individual has been infected—even though it may be undetected by over-the-counter (OTC) tests, a new study finds. The findings, established by a research team from the Institut Pasteur in France and […]

New research points to possible reason for long COVID

A Spanish study suggests that SARS-CoV-2 mediated vagus nerve dysfunction (VND) could be responsible for long COVID. By SHIRA SILKOFF, FEBRUARY 2022 – The Jerusalem Post Many symptoms of post-COVID syndrome could be caused by lasting damage sustained to one of the most important nerves in the human body during initial infection with coronavirus, new research has […]

Many long-covid symptoms linger even after two years, new study shows

By Amy Goldstein, 2023, The Washington Post People who endured even mild cases of covid-19 are at heightened risk two years later for lung problems, fatigue, diabetes and certain other health problems typical of long covid, according to a new studythat casts fresh light on the virus’s true toll. The analysis, published Monday in the journal […]

Runaway immune reactions cause long COVID breathing problems

Author: Christopher Vaughan, Stanford Medicine 2023 Stanford Medicine researchers have found a mechanism behind one of the most common symptoms of long COVID — shortness of breath. Post COVID-19 breathing problems are caused by a condition known as lung fibrosis, when damaged lungs form scar tissue, which makes it difficult for lungs to expand and […]

Severe Respiratory Disease Among Children With and Without Medical Complexity During the COVID-19 Pandemic

Christina Belza, PhD, MN; Eleanor Pullenayegum, PhD, Katherine E. Nelson, MD, PhD; et al ,JAMA Netw Open. 2023;6(11):e2343318. doi:10.1001/jamanetworkopen.2023.43318 Key Points Question  Did rates and outcomes of severe respiratory illness change during the first 2 years of the pandemic, compared with prepandemic, among children with medical complexity and those without medical complexity? Findings  In this repeated cross-sectional study of 139 078 respiratory hospitalizations in Canada, there were more […]

C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps

Bruna M. Silva,1,2 Giovanni F. Gomes,1 Flavio P. Veras,1 Seppe Cambier,3 Gabriel V.L. Silva,1,2 Andreza U. Quadros,1 Diego B. Caetité,1,2 Daniele C. Nascimento,1,2 Camilla M. Silva,1,2 Juliana C. Silva,1 Samara Damasceno,1 Ayda H. Schneider,1 Fabio Beretta,3 Sabrina S. Batah,4 Icaro M.S. Castro,5 Isadora M. Paiva,1 Tamara Rodrigues,1,2 Ana Salina,1,6 Ronaldo Martins,6,7 Guilherme C.M. Cebinelli,1,2 Naira L. Bibo,1 Daniel M. Jorge,6,7 Helder I. Nakaya,5 Dario S. Zamboni,1,6 Luiz O. Leiria,1,2 Alexandre T. Fabro,4 José C. Alves-Filho,1,2 Eurico Arruda,6,7 Paulo Louzada-Junior,1,8 Renê D. Oliveira,1,8 Larissa D. Cunha,1,6 Pierre […]

Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19

Janessa Y.J. Tan,1 Danielle E. Anderson,2,3 Abhay P.S. Rathore,4 Aled O’Neill,1 Chinmay Kumar Mantri,1 Wilfried A.A. Saron,1 Cheryl Q.E. Lee,5 Chu Wern Cui,5 Adrian E.Z. Kang,1 Randy Foo,1 Shirin Kalimuddin,1,6 Jenny G. Low,1,6 Lena Ho,5 Paul Tambyah,7,8 Thomas W. Burke,9 Christopher W. Woods,9,10 Kuan Rong Chan,1 Jörn Karhausen,4,11 and Ashley L. St. John1,4,12,13 Published August 10, 2023 – 10.1172/JCI149834 Journal of Clinical Investigation Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in patients […]

Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis

James May, Jane A. Mitchell, and R. Gisli Jenkins, Published September 15, 2023 – 10.1172/JCI172058 Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor survival. The incidence and mortality of IPF are rising, but treatment remains limited. Currently, two drugs can slow the scarring process but often at the expense of intolerable side […]

SARS-CoV-2 particles promote airway epithelial differentiation and ciliation

Julian Gonzalez-Rubio1 Vu Thuy Khanh Le-Trilling2 Lea Baumann1 Maria Cheremkhina1 Hannah Kubiza1 Anja E. Luengen1,3 Sebastian Reuter3 Christian Taube3 Stephan Ruetten4 Daniela Duarte Campos5 Christian G. Cornelissen1,6 Mirko Trilling2 Anja Lena Thiebes1, Front. Bioeng. Biotechnol., 02 November 2023 Sec. Tissue Engineering and Regenerative MedicineVolume 11 – 2023 | Introduction: The Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which caused the coronavirus disease 2019 (COVID-19) pandemic, enters the […]