Author: John Murphy, M.D. CEO Covid-19 Long-haul Foundation Abstract Messenger RNA (mRNA) vaccines have revolutionized infectious disease prevention, offering rapid deployment and robust immunogenicity. However, emerging evidence suggests that the […]
🧬 Spike Protein Modifications: Scientific Possibilities
If a scientist were hypothetically attempting to modify the SARS-CoV-2 spike protein for enhanced function—whether for research, vaccine design, or malicious intent—there are specific genomic regions and tools they might […]
Endothelial Dysfunction and Spike Protein Persistence in Long COVID: Mechanisms, Vulnerabilities, and Clinical Evidence
Author: John Murphy, President, COVID-19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is characterized by persistent symptoms affecting multiple organ systems. Among its most compelling […]
The SARS-CoV-2 Spike Protein: Architecture, Binding Dynamics, and Clearance Evolution Over Five Years
John Murphy, President The COVID Long-haul Foundation Abstract The SARS-CoV-2 spike (S) protein is the principal mediator of viral entry and a key determinant of COVID-19 pathogenesis. This article provides […]
The Spike That Stays: How the COVID-19 Spike Protein Continues to Shape Human Health
By John Murphy, The COVID 19 Long-haul Foundation When the SARS-CoV-2 virus first emerged, the world’s attention quickly turned to its crown-like protrusions—the spike proteins that give coronaviruses their name. […]
🧠 COVID-19 Vaccines and Endothelial Dysfunction: Insights from 2025 Research
1. Endothelial Activation in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Source: Blood Advances, June 2025 Researchers used a microfluidic “Endo-chip” to study endothelial responses to serum from patients with VITT following the […]
🧬 Mechanistic and Genomic Insights: COVID-19 Vaccines and Pulmonary Fibrosis
Overview While COVID-19 vaccines have been instrumental in reducing severe disease and mortality, emerging research has explored potential links between vaccination and fibrotic lung responses in rare cases. This article […]
🧬 Mechanistic Failures and Genomic Concerns of COVID-19 mRNA Vaccines: A Critical Review
Introduction COVID-19 mRNA vaccines were developed with unproven and risky speed and deployed globally to combat a novel virus. While they have reduced severe disease in some populations, emerging peer-reviewed […]
🧪 COVID Spike Protein and Kidney Damage: Stage 3B Illness, Fluid Retention, and Electrolyte Recovery
As research into Long COVID and post-vaccination syndromes deepens, 2025 peer-reviewed studies have identified a troubling link between spike protein persistence and kidney damage, particularly in patients progressing to Stage […]
Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination
Bornali Bhattacharjee, Peiwen Lu, Valter Silva Monteiro, et. al. doi: https://doi.org/10.1101/2025.02.18.25322379 Yale Study Reveals Shocking Truth: Spike Protein Lingers – and Grows SUMMARY COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the […]