A Mechanism-Driven Reframing of Therapeutic Development in Post–Acute SARS-CoV-2 Disease John Murphy, M.D, M.P.H., D.P.H. President COVID Long-haul Foundation Conceptual Shift and Therapeutic Reclassification ABSTRACT For much of the early […]
Long COVID–Associated Vertigo: Etiology, Pathophysiology, Clinical Course, and Therapeutic Strategies
John Murphy, CEO The COVID-19 Long-haul Foundation Introduction Persistent vertigo and disequilibrium have emerged as prominent neurological sequelae of post-acute SARS-CoV-2 infection, commonly termed long COVID. While early pandemic focus […]
Pharmacologic Management of Long COVID: Mechanisms, Therapeutics, Risks, and Emerging Clinical Trials
John Murphy, CEO, The Covid-Long haul Foundation Abstract Long COVID (Post-Acute Sequelae of SARS-CoV-2 infection, PASC) is a heterogeneous, multi-system disorder characterized by persistent symptoms following acute infection. Affecting tens […]
Understanding metformin use and Long COVID and ME/CFS
RECOVER researchers shared how the prescription drug metformin may reduce the risk of Long COVID and presented research examining the risk of developing myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) after a […]
Post–Acute Sequelae of Long COVID): Comprehensive Clinical Evaluation, Diagnostic Strategy, and Evidence-Based Management
John Murphy, CEO The COVID-19 Long haul Foundation Abstract Post–acute sequelae of SARS-CoV-2 infection (PASC), widely referred to as Long COVID, has emerged as a complex, heterogeneous, and often debilitating […]
FDA intends to put its most serious warning on Covid vaccines, sources say
By Ben Tinker, Brenda Goodman, Meg Tirrell, CNN The US Food and Drug Administration intends to put a “black box” warning on Covid-19 vaccines, according to two people familiar with […]
The Emergence of Escape Mutations in COVID-19 Following Anti-Spike Monoclonal Antibody Treatment: How Do We Tackle It?
Focosi D , Franchini M, Maggi F, Casadevall A, DOI https://doi.org/10.2147/IDR.S540928 Abstract: Treatment-emergent resistance to anti-Spike monoclonal antibody (mAb) was a largely unexpected and dramatic finding along the COVID-19 pandemic. Emergence of resistant strains was particularly […]
Association Between Vitamin A and D Status and the Risk of COVID-19 in the Elderly Population: A Single-Center Experience
Li T , Cui X , Li X, Yang J, Wang H, Yang J, Jin Z, Published 24 June 2025 Volume 2025:18 Pages 8233—8241,DOI https://doi.org/10.2147/JIR.S522566 Background: Studies have confirmed that vitamins A and D are related to the coronavirus disease […]
Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics
Grant McGee Talkington, Paresh Kolluru, Timothy E. Gressett, et. al., Frontiers in Neurology One lingering effect of the COVID-19 pandemic created by SARS-CoV-2 is the emergence of Long COVID (LC), […]
Persistent SARS-CoV-2 Spike Protein: Genomic Modulation, Immune Dysregulation, and Impaired Antibody Maturation
Author: John Murphy, CEO COVID 19 Long-haul Foundation Abstract The SARS-CoV-2 spike glycoprotein, central to viral entry and the target of mRNA vaccine platforms, has emerged as a persistent antigen […]