Long COVID: major findings, mechanisms and recommendations


Hannah E. Davis, , Lisa McCorkell, Julia Moore Vogel, Eric J. Topol Nature Reviews Microbiology volume 21, pages133–146 (2023)Cite this article Abstract Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals […]

COVID-19 Can Remain Undetected In Lungs For 18 Months: Study


DEC 14, 2023 – Authored by Amie Dahnke via The Epoch Times  The COVID-19 virus can remain in the lungs for months after an individual has been infected—even though it may be undetected by over-the-counter (OTC) tests, a new study finds. The findings, established by a research team from the Institut Pasteur in France and […]

Breathing difficulties after covid-19: a guide for primary care


BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2023-074937 , June 2023) Cite this as: BMJ 2023;381:e074937, Rachael Evans, Anton Pick, et. al. What you need to know Around one in four adults who were hospitalised with covid-19 and one in six who were not hospitalised experience persistent breathing difficulties beyond four weeks after SARS-CoV-2 infection,12 and a cohort study in China demonstrated that breathlessness can persist […]

Runaway immune reactions cause long COVID breathing problems


Author: Christopher Vaughan, Stanford Medicine 2023 Stanford Medicine researchers have found a mechanism behind one of the most common symptoms of long COVID — shortness of breath. Post COVID-19 breathing problems are caused by a condition known as lung fibrosis, when damaged lungs form scar tissue, which makes it difficult for lungs to expand and […]

Who Is Most at Risk for Long COVID?


Demographic, clinical characteristics offer hints for caregivers, policymakers By JAKE MILLER March 8, 2023 Research This article is part of Harvard Medical School’s continuing coverage of COVID-19. A new study of more than 800,000 people has found that in the U.S., COVID “long haulers” were more likely to be older and female, with more chronic conditions than people in […]

Cardiorespiratory dysautonomia in post-COVID-19 condition: Manifestations, mechanisms and management


Artur Fedorowski, Monika Fagevik Olsén, Frida Nikesjö, Christer Janson, Judith Bruchfeld, Maria Lerm, Kristofer Hedma: May 2023, Journal of Internal MedicineVolume 294, Issue 5 p. 548-562 Abstract A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately 1 out of 10 COVID-19 convalescents reports persistent health issues more than 3 months after […]

Study Identifies Four Major Subtypes of Long COVID


DECEMBER 21, 2022, Nature Medicine SARS-CoV-2 coronavirus, the virus which causes COVID-19, scientifically accurate 3D illustration showing surface spikes of the virus. Credit: Shutterstock The post-COVID syndrome known as long COVID has four major subtypes defined by different clusters of symptoms, according to a study led by researchers at Weill Cornell Medicine. The study, published Dec. […]

Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome


N. Azcue, R. Del Pino, et. al., Journal of Translational Medicine volume 21, Article number: 814 (2023)  Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic and neuropathic symptoms. Methods The study included 87 patients with post-COVID condition, 50 patients with ME/CFS, and 50 healthy controls (HC). The hemodynamic autonomic function was […]

C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps


Bruna M. Silva,1,2 Giovanni F. Gomes,1 Flavio P. Veras,1 Seppe Cambier,3 Gabriel V.L. Silva,1,2 Andreza U. Quadros,1 Diego B. Caetité,1,2 Daniele C. Nascimento,1,2 Camilla M. Silva,1,2 Juliana C. Silva,1 Samara Damasceno,1 Ayda H. Schneider,1 Fabio Beretta,3 Sabrina S. Batah,4 Icaro M.S. Castro,5 Isadora M. Paiva,1 Tamara Rodrigues,1,2 Ana Salina,1,6 Ronaldo Martins,6,7 Guilherme C.M. Cebinelli,1,2 Naira L. Bibo,1 Daniel M. Jorge,6,7 Helder I. Nakaya,5 Dario S. Zamboni,1,6 Luiz O. Leiria,1,2 Alexandre T. Fabro,4 José C. Alves-Filho,1,2 Eurico Arruda,6,7 Paulo Louzada-Junior,1,8 Renê D. Oliveira,1,8 Larissa D. Cunha,1,6 Pierre […]

Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19


Janessa Y.J. Tan,1 Danielle E. Anderson,2,3 Abhay P.S. Rathore,4 Aled O’Neill,1 Chinmay Kumar Mantri,1 Wilfried A.A. Saron,1 Cheryl Q.E. Lee,5 Chu Wern Cui,5 Adrian E.Z. Kang,1 Randy Foo,1 Shirin Kalimuddin,1,6 Jenny G. Low,1,6 Lena Ho,5 Paul Tambyah,7,8 Thomas W. Burke,9 Christopher W. Woods,9,10 Kuan Rong Chan,1 Jörn Karhausen,4,11 and Ashley L. St. John1,4,12,13 Published August 10, 2023 – 10.1172/JCI149834 Journal of Clinical Investigation Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in patients […]