Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), initially characterized as a respiratory pathogen, is now recognized as a systemic vascular and neurotropic disease with profound effects upon the central […]
NIH RECOVER Clinical Trials and the First Emergence of Interventional Results in Long COVID Research: A Translational Turning Point
A Scholarly Review for Scientific American (Submission-Style Manuscript) John Murphy, M.D., M.P.H., D.P.H., President, COVID-19 Long-Haul Foundation Abstract The NIH RECOVER Initiative represents the largest coordinated research program investigating post–acute […]
Recognition of Long COVID as a Heterogeneous Post-Infectious Syndrome
Toward a Multisystem Endotype Framework for Post–Acute SARS-CoV-2 Disease John Murphy, M.D., M.P.H., D.P.H. President Covid-19 Long-haul Foundation Abstract Long COVID (post–acute sequelae of SARS-CoV-2 infection, PASC) has emerged as […]
COVID-19–Associated Gustatory Dysfunction: Pathophysiology, Clinical Trajectory, and Therapeutic Strategies
A Comprehensive Clinical and Mechanistic Review Author: John Murphy, M.D., M.P.H., D.P.H.Affiliation: COVID-19 Long-haul Foundation Abstract Background: Alterations in taste perception (dysgeusia and ageusia) emerged as a hallmark symptom of […]
Cerebral amyloid angiopathy – Related inflammation after COVID-19 vaccination: Case or causality?
Francesco Rossato a, Gianmarco Gazzola a, Valentina Carlucci a, et. al. PMCID: PMC8498485 Background and aims Cerebral amyloid angiopathy (CAA) is characterized by microangiopathy with increased susceptibility to hemorrhages. Some patients may develop an inflammatory form […]
Saliva and SARS-CoV-2 Infection: Molecular, Immunologic, and Clinical Perturbations of the Salivary System in COVID-19
John Murphy, M.D., M.P.H., D.P.H. Abstract Background: Saliva has emerged as a central biological medium in SARS-CoV-2 infection, functioning simultaneously as a diagnostic fluid, a viral reservoir, and a reflection […]
Long COVID–Associated Vertigo: Etiology, Pathophysiology, Clinical Course, and Therapeutic Strategies
John Murphy, CEO The COVID-19 Long-haul Foundation Introduction Persistent vertigo and disequilibrium have emerged as prominent neurological sequelae of post-acute SARS-CoV-2 infection, commonly termed long COVID. While early pandemic focus […]
Persistent attenuation of lymphocyte subsets after mass SARS-CoV-2 infection
Zhengqi Jiang ∙ Tichao Shan∙ Yucan Li ∙ Heyu Ni ∙ et. al., DOI: 10.1016/j.ijid.2025.108287 External Link Also available on ScienceDirect External Link Highlights SARS-CoV-2 causes lasting immune dysregulation for over 20 months. The impact of SARS-CoV-2 on lymphocytes was especially severe in patients […]
We’re losing decades of our life to this illness’: long Covid patients on the fear of being forgotten
Kathryn Bromwich On 20 March 2020, Rowan Brown started to feel a tickle at the back of her throat. Over the next few days, new symptoms began to emerge: difficulty […]
Vestibulocochlear Dysfunction in COVID-19 and Following Immunisation: Mechanistic Insights, Clinical Phenotypes, and Therapeutic Implications
Abstract Since the global emergence of COVID-19, attention has increasingly turned toward its extrapulmonary manifestations, including involvement of the auditory and vestibular systems. Reports of tinnitus, vertigo, and sudden sensorineural […]