Category: Pathology

SARS-CoV-2 infection and persistence in the human body and brain at autopsy

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Sydney R. Stein, Sabrina C. Ramelli, Alison Grazioli, Joon-Yong Chung, Manmeet Singh, Claude Kwe Yinda, Clayton W. Winkler, Junfeng Sun, James M. Dickey, Kris Ylaya, Sung Hee Ko, et. al. Nature volume 612, pages758–763 (2022)Cite this article Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction1,2,3 during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients experiencing prolonged symptoms, termed post-acute sequelae of SARS-CoV-2 […]

Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19

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Janessa Y.J. Tan,1 Danielle E. Anderson,2,3 Abhay P.S. Rathore,4 Aled O’Neill,1 Chinmay Kumar Mantri,1 Wilfried A.A. Saron,1 Cheryl Q.E. Lee,5 Chu Wern Cui,5 Adrian E.Z. Kang,1 Randy Foo,1 Shirin Kalimuddin,1,6 Jenny G. Low,1,6 Lena Ho,5 Paul Tambyah,7,8 Thomas W. Burke,9 Christopher W. Woods,9,10 Kuan Rong Chan,1 Jörn Karhausen,4,11 and Ashley L. St. John1,4,12,13 Published August 10, 2023 – 10.1172/JCI149834 Journal of Clinical Investigation Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in patients […]

Spectrum of Fibrotic Lung Diseases

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Marlies Wijsenbeek, M.D., and Vincent Cottin, M.D.  New England Journal of Medicine 2023 Diffuse parenchymal lung diseases encompass a large number of conditions, with a wide range of causes, clinical manifestations, and imaging and pathological features, as well as variable outcomes. Despite the intrinsic heterogeneity of this group of diseases, in most of them, the […]

SARS-CoV-2 infection and persistence in the human body and brain at autopsy

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Authors: by Covid Strategies | Dec 14, 2022 | Science & News Nature Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction1,2,3 during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients experiencing prolonged symptoms, termed post-acute sequelae of SARS-CoV-2 (refs. 4,5). However, the burden of infection outside the respiratory tract and time to viral clearance […]

COVID-19 Autopsies Uncover Ways The Coronavirus Kills April 29, 2021 Angus Chen

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When patients become severely ill with COVID-19, the coronavirus infiltrates deep into the lungs and causes mayhem on the tissues that line the organ. The infection can cause swelling, and fluid and debris can start to fill the lungs. It can feel like drowning on dry land. Patients who remember being intubated sometimes describe the […]

Pathophysiology and Management of Tongue Involvement in COVID-19 Patients

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Authors: Zeinab Mohseni Afshar, Mohammad Barary, Soheil Ebrahimpour, Alireza Janbakhsh, Mandana Afsharian, Amirhossein Hasanpour & Arefeh Babazadeh Indian Journal of Otolaryngology and Head & Neck Surgery (2022) Abstract Evaluate the lingual manifestations of COVID-19, and provide a clinical guide in managing these symptoms. Electronic databases, such as PubMed/Medline, and Scopus were searched until November 1, 2020, and only randomized controlled trials, cross-sectional and cohort […]

‘Never Seen’ Before: Embalmers Finding Long, Rubbery Clots Inside Corpses Since Implementation of Covid Vaccines

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By Cristina Laila September 4, 2022 Embalmers are finding long, rubbery clots inside of corpses since the implementation of Covid vaccines. According to one Alabama embalmer who has been treating corpses for over 20 year, the strange fibrous clots emerged in May of 2021, shortly after the Covid vaccines first became available to the public. “It […]

Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

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Authors: Ibolya Rutkai, Meredith G. Mayer, Linh M. Hellmers, Bo Ning, Zhen Huang, Christopher J. Monjure, Carol Coyne, Rachel Silvestri, Nadia Golden, Krystle Hensley, Kristin Chandler, Gabrielle Lehmicke, Gregory J. Bix, Nicholas J. Maness, Kasi Russell-Lodrigue, Tony Y. Hu, Chad J. Roy, Robert V. Blair, Rudolf Bohm, Lara A. Doyle-Meyers, Jay Rappaport & Tracy Fischer  Nature Communications volume 13, Article number: 1745 (2022)  Published: 01 April 2022 Abstract Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren’t well […]

Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives

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Authors: Giovanni Genovese,a,bChiara Moltrasio,a,cEmilio Berti,a,b and Angelo Valerio Marzanoa,b,* Dermatology. 2020 Nov 24 : 1–12.Published online 2020 Nov 24. doi: 10.1159/000512932PMCID: PMC7801998PMID: 33232965 Abstract Background Coronavirus disease-19 (COVID-19) is an ongoing global pandemic caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), which was isolated for the first time in Wuhan (China) in December 2019. Common symptoms include fever, cough, fatigue, […]

First case of postmortem study in a patient vaccinated against SARS-CoV-2

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Author:TorstenHansenaUlfTitzeaNidhi Su AnnKulamadayil-HeidenreichbSabineGlombitzacJohannes, et. al. Highlights • We report on a patient with a single dose of vaccine against SARS-CoV-2. • He developed relevant serum titer levels but died 4 weeks later. • By postmortem molecular mapping, we found viral RNA in nearly all organs examined. • However, we did not observe any characteristic morphological features of COVID-19. • […]