John Murphy, CEO The COVID-19 Long-haul Foundation Introduction The unprecedented global spread of COVID-19 initiated one of the most intensive scientific investigations in modern medical history. While the acute phase […]
Long COVID, Chronic Urticarial Pruritus
Background John Murphy, CEO COV-19 Long-haul Foundation Persistent dermatologic manifestations represent an increasingly recognized component of post-acute sequelae of SARS-CoV-2 infection (PASC), commonly termed Long COVID. Among these manifestations, chronic […]
Long COVID and Sleep Disorders: An Emerging Biologic Nexus in Post-Acute Sequelae of SARS-CoV-2 Infection
John Murphy, CEO, COVID-19 Long-haul Foundation Abstract Sleep disturbance has emerged as one of the most prevalent, persistent, and disabling manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), commonly known […]
Long-COVID Brain Fog: Reconsidering the Centrality of Ongoing Neuroinflammation
A Mechanistic Reappraisal of Cognitive Dysfunction Following SARS-CoV-2 Infection Author: John Murphy, CEO, COVID-19 Long-haul Foundation Abstract “Brain fog” in Long COVID has often been attributed to persistent neuroinflammation driven […]
Long COVID and Vascular Injury in 2026: Emerging Evidence for Endothelial Dysfunction, Microvascular Disease, and Persistent Immunothrombotic Pathology
John Murphy, M.D., M.P.H., D.P.H. President COVID-19 Long-haul Foundation Abstract Long COVID, also termed post-COVID condition or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as one of the most […]
Treatment Landscape in Long COVID Has Expanded Beyond “Supportive Care”
A Mechanism-Driven Reframing of Therapeutic Development in Post–Acute SARS-CoV-2 Disease John Murphy, M.D, M.P.H., D.P.H. President COVID Long-haul Foundation Conceptual Shift and Therapeutic Reclassification ABSTRACT For much of the early […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
Severe cerebral amyloid angiopathy related inflammation (CAA-ri) associated with vaccination
Michael Tang 1, Jane Kim 2, Kui Kai Lau 3, Koon Ho Chan 3, PMID: 39094435, DOI: 10.1016/j.jneuroim.2024.578406 Abstract Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rapid but reversible autoimmune encephalopathy where spontaneous autoantibody reaction against amyloid beta deposited […]
Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation–a controlled study
Roald Omdal, Ole Bernt Lenning, Grete Jonsson, Scientific Reports , Article number: (2026) Cite this article We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript […]
A case of cerebral amyloid angiopathy related inflammation after vaccination against SARS-CoV-2
Mai Yamakawa 1, Sharon Lynch 1, Ryan Townley 1,⁎ , PMCID: PMC9308493 Abstract Background Cerebral amyloid angiopathy related inflammation (CAA-RI) is a neuroinflammatory disease that is associated with perivascular amyloid- deposition. Case presentation A middle-aged […]