Inflammation

ARDS / Genomics / Hyperinflammation / Inflammasome / Inflammation / Inflammatory Markers / Phenotype / Precision phenotyping / Severity Posted on: November 3, 2026September 12, 2026

Five Years of Evidence on COVID-19 Severity and Clinical Phenotypes

John Murphy, CEO The COVID-19 Long haul Foundation: Original Research Study An Integrated Analysis of Government, Public, Electronic Health-Record, Genomic, and Published Clinical Databases, 2020–2025 Abstract Background: COVID-19 is frequently […]

Cortisol / Inflammation / Long COV / Long-haul Disease / Long-term Effects / Multimodal biological signatures / network disease / PASC Posted on: October 25, 2026September 10, 2026

The Biological Signature of Long COVID

What the World’s Largest Clinical and Molecular Datasets Are Beginning to Reveal John Murphy, CEO, The COVID-19 Long-haul Foundation Abstract Long COVID presents one of the most consequential unresolved problems […]

Cardiovascular / Fatigue / Gastrointestinal / Inflammation / Metabolic Dysregulation / Neurocognitive / Neuropathy / Phenotype / Postural Orthostatic Tachycardia (POTS) / Respiratory Syndrome / Vascular System Posted on: September 12, 2026August 23, 2026

Long COVID as a Spectrum of Distinct Biological Phenotypes

A mechanistic synthesis of the emerging phenotype-based model of post-acute sequelae of SARS-CoV-2 infection John Murphy, CEO The COVID-19 Long haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 […]

Autonomic dysfunction / Eczema / Edema / Epidermis / Inflammation / Itch / Itching / Pernio lesions / Pigmentary alteration / Rash: Pernio / Skin Discoloration / Skin-Dermatology Posted on: September 8, 2026August 21, 2026

The Epidermal Footprint of Long COVID

John Murphy, CEO, The COVID-19 Long haul Foundation A narrative review Abstract BackgroundPost-COVID-19 condition, commonly termed long COVID, is a multisystem disorder in which symptoms persist, recur, or newly develop […]

Acute transverse myelitis / Axonal Injury / Blood brain barrier / Concerns / Cytokine Storm / Encephalomyelitis / Encephalopathy / Epidemiology / Gray matter / Guillain Barre / Guillian-Barre Syndrome / Inflammation / Ischemic Stroke / Neurologic Effects / Neuromyelitis optica / Oligodendrocyte injury / Oxidative stress / Transverse Myelitis / Vaccine Enhanced Disease / Vaccine News / Vaccine Safety / White matter Posted on: August 18, 2026August 9, 2026

Transverse myelitis:Genomics, Cell Biology, Clinical Manifestations, Diagnosis, Treatment, and Long-Term Prognosis

Author: John Murphy, CEO, The COVID-19 Long Haul Foundation Abstract Background Transverse myelitis (TM) is an uncommon inflammatory disorder of the spinal cord characterized by acute or subacute neurological dysfunction […]

ACE2 Receptors / Adipose / Endothelium / Immune System / Inflammation / Tissue Reservoir / Tropism / Viral persistence Posted on: August 3, 2026July 17, 2026

Viral Persistence and Tissue Reservoirs in SARS-CoV-2 Infection: Implications for Long COVID

John Murphy, CEO The COVID-19 Long-haul Foundation Introduction The unprecedented global spread of COVID-19 initiated one of the most intensive scientific investigations in modern medical history. While the acute phase […]

Dysautonomia / Epidermis / Epithelium / Immune dysregulation / Inflammation / Itch / Itching / Mast Cell / Mast cell activation syndrome / Skin-Dermatology Posted on: July 14, 2026June 30, 2026

Long COVID, Chronic Urticarial Pruritus

Background John Murphy, CEO COV-19 Long-haul Foundation Persistent dermatologic manifestations represent an increasingly recognized component of post-acute sequelae of SARS-CoV-2 infection (PASC), commonly termed Long COVID. Among these manifestations, chronic […]

Anxiety / Circadian Rhythm / Cognitive deficit / Depression & Mental Health / Fatigue / Inflammation / Mitochondria / Neurologic Effects / PASC / Sleep & Dreams / Sleep Deprivation / Sleep Disturbance Posted on: July 11, 2026June 23, 2026

Long COVID and Sleep Disorders: An Emerging Biologic Nexus in Post-Acute Sequelae of SARS-CoV-2 Infection

John Murphy, CEO, COVID-19 Long-haul Foundation Abstract Sleep disturbance has emerged as one of the most prevalent, persistent, and disabling manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), commonly known […]

Biomarker / Biomarkers / Brain / Cognitive deficit / Cognitive Deficits / Inflammation / Neuroinflammation Posted on: July 7, 2026June 20, 2026

Long-COVID Brain Fog: Reconsidering the Centrality of Ongoing Neuroinflammation

A Mechanistic Reappraisal of Cognitive Dysfunction Following SARS-CoV-2 Infection Author: John Murphy, CEO, COVID-19 Long-haul Foundation Abstract “Brain fog” in Long COVID has often been attributed to persistent neuroinflammation driven […]

Clots & Bleeds / Endothelium / Hyperinflammation / Inflammasome / Inflammation / ME/CFS / Nitric oxide Posted on: July 2, 2026July 2, 2026

Long COVID and Vascular Injury in 2026: Emerging Evidence for Endothelial Dysfunction, Microvascular Disease, and Persistent Immunothrombotic Pathology

John Murphy, M.D., M.P.H., D.P.H. President COVID-19 Long-haul Foundation Abstract Long COVID, also termed post-COVID condition or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as one of the most […]