By Theo Farrant New research offers what scientists describe as the first biological evidence of Long COVID brain fog. Scientists in Japan have identified a potential biological cause of Long COVID brain fog, […]
Research highlighting chronic inflammation opens path to treating illness that affects millions of Americans
A new study from investigators at Harvard and Beth Israel Deaconess Medical Center sheds light on why some people never fully recover from COVID-19. In research that analyzed blood samples […]
Blackout Syndromes in Long-COVID: Etiology, Physiology, Pathology, and Clinical Determinants
John Murphy, M.D., M.P.H., DPH, President The Covid Long-haul Foundation AbstractPersistent transient loss of consciousness and pre-syncope (“blackout phenomena”) are increasingly recognized sequelae in patients with post-acute sequelae of SARS-CoV-2 […]
Chronic Inflammation Pathways Identified in Long COVID
I. Persistent Cytokine-Driven Inflammatory Signaling I.A. IL-6–Centered Inflammatory Axis Interleukin-6 (IL-6) has emerged as one of the most consistently elevated cytokines in Long COVID cohorts, serving as a central node […]
Inflammatory Markers as Predictors of Onset and Recovery of Olfactory and Gustatory Dysfunction in COVID-19 Patients
Burak Celik • Fatih Gul • Hacı Huseyin Dere, DOI: 10.7759/cureus.96003 Abstract Background Olfactory and gustatory dysfunctions are widely recognized as characteristic manifestations of COVID-19. However, the relationship between disease severity, inflammatory markers, and the […]
Inflammation: The Molecular Convergence of Gout, COVID-19, and Uric Acid Metabolism
Inflammation is not merely a symptom—it is a biological imperative. It orchestrates the body’s defense against infection, injury, and metabolic imbalance. Yet when dysregulated, inflammation becomes a crucible for chronic […]
OPG and TNFR1 as Potential Biomarkers of Inflammation in Older Adults with Acute COVID-19
Ramon-Luing LA , Flores-Gonzalez J , Cataneo-Piña DJ, et. al., DOI https://doi.org/10.2147/JIR.S545926 Background: Older individuals are at high risk for severe COVID-19 and often experience geriatric syndromes as post-COVID-19 sequelae associated with inflammation. Osteoprotegerin (OPG) and Tumor […]
Post-Spike Syndrome and Spikeopathy: Central Mechanisms in Long COVID Pathophysiology
Author: John Murphy, President COVID 19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a multifaceted syndrome affecting millions globally. While initial hypotheses […]
Neuroinflammatory and Glutamatergic Dysregulation in Long COVID: Treating Brain Fog, Confusion, and Depression
John Murphy, – President, COVID-19 Long-haul Foundation Pathophysiology of Long COVID Neurocognitive Sequelae Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is increasingly recognized as a chronic, multisystemic condition […]
Endothelial Dysfunction and Spike Protein Persistence in Long COVID: Mechanisms, Vulnerabilities, and Clinical Evidence
Author: John Murphy, President, COVID-19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), is characterized by persistent symptoms affecting multiple organ systems. Among its most compelling […]