Category: Inflammation

Cutting Edge: Hyperinflammatory Monocytes Expressing CD56 Abound in Severe COVID-19 Patients 

Posted on | Posted on John Murphy | Leave a Comment on Cutting Edge: Hyperinflammatory Monocytes Expressing CD56 Abound in Severe COVID-19 Patients 

Stefania Campana; Claudia De Pasquale; Giacomo Sidoti Migliore;, et. al. J Immunol (2022) 209 (4): 655–659. https://doi.org/10.4049/jimmunol.2200021 Abstract Proinflammatory monocytes play a preponderant role in the development of a cytokine storm causing fatal consequences in coronavirus disease 2019 (COVID-19) patients, highlighting the importance of analyzing in more detail monocyte distribution in these patients. In this study, […]

The Invisible Damage: How COVID Rewires Our Brains

Posted on | Posted on John Murphy | Leave a Comment on The Invisible Damage: How COVID Rewires Our Brains

By University of Colorado at Boulder, University of Colorado Boulder scientists have discovered that proteins left by COVID-19 can significantly lower cortisol levels in the brain, leading to heightened immune responses to new stressors. This research, focusing on the neurological symptoms of Long COVID, utilized rats to demonstrate how SARS-CoV-2 antigens persist in the body and alter brain function. This […]

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo

Posted on | Posted on John Murphy | Leave a Comment on IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo

Shreya Ghimire, Biyun Xue, Kun Li, Ryan M Gannon, et. al.doi: https://doi.org/10.1101/2024.07.03.60194 Abstract Treatments available to prevent progression of virus-induced lung diseases, including coronavirus disease 2019 (COVID-19) are of limited benefit once respiratory failure occurs. The efficacy of approved and emerging cytokine signaling-modulating antibodies is variable and is affected by disease course and patient-specific inflammation patterns. Therefore, understanding the role of inflammation on the […]

Intramyocardial Inflammation after COVID-19 Vaccination: An Endomyocardial Biopsy-Proven Case Series

Posted on | Posted on John Murphy | Leave a Comment on Intramyocardial Inflammation after COVID-19 Vaccination: An Endomyocardial Biopsy-Proven Case Series

Authors: Christian Baumeier 1, Ganna Aleshcheva 1, Dominik Harms 1, et. al. Int J Mol Sci 2022 Jun 22;23(13):6940. doi: 10.3390/ijms23136940. Abstract Myocarditis in response to COVID-19 vaccination has been reported since early 2021. In particular, young male individuals have been identified to exhibit an increased risk of myocardial inflammation following the administration of mRNA-based vaccines. Even though the first epidemiological analyses […]

Dynamic Assessment of Hematological Parameters as Predictive Biomarkers for Disease Severity and Prognosis in COVID-19 Patients: A Longitudinal Study

Posted on | Posted on John Murphy | Leave a Comment on Dynamic Assessment of Hematological Parameters as Predictive Biomarkers for Disease Severity and Prognosis in COVID-19 Patients: A Longitudinal Study

Aparna P. Patange • Jabbar V. Desai • Bhupal Pujari • Aparna Marwah • Animesh Dey, Published: July 01, 2024, DOI: 10.7759/cureus.63593  Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to substantial morbidity and mortality worldwide. Hematological abnormalities are common in COVID-19 patients and play a significant role in disease pathogenesis and prognosis. Objective: […]

Pathological sequelae of long-haul COVID

Posted on | Posted on John Murphy | Leave a Comment on Pathological sequelae of long-haul COVID

Saurabh Mehandru & Miriam Merad, Nature Immunology volume 23, pages194–202 ( Abstract The world continues to contend with successive waves of coronavirus disease 2019 (COVID-19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and often debilitating sequelae are increasingly recognized in convalescent individuals, named ‘post-COVID-19 syndrome’ or ‘long-haul COVID’. Clinical symptomatology includes fatigue, malaise, dyspnea, defects […]

POST-ACUTE SEQUELAE OF COVID-19: CHARACTERIZATION, COMORBIDITIES, AND BIOMARKERS IN A DIVERSE COHORT

Posted on | Posted on John Murphy | Leave a Comment on POST-ACUTE SEQUELAE OF COVID-19: CHARACTERIZATION, COMORBIDITIES, AND BIOMARKERS IN A DIVERSE COHORT

Emily Struttmann, Anish Shah, Matthew Moreida, et. al. doi: https://doi.org/10.1101/2024.06.20.24308901 Abstract Introduction Post-acute sequelae of COVID-19 (PASC) is causing a silent pandemic in the U.S. Gulf South, a part of flyover U.S. where patients are quietly withdrawing from the workforce and largely disconnected from the advocacy resources growing in more affluent regions[1]. To date, there is no clinical test to diagnose PASC […]

Increased frequency and mortality in persons with neurological disorders during COVID-19 

Posted on | Posted on John Murphy | Leave a Comment on Increased frequency and mortality in persons with neurological disorders during COVID-19 

Candace M Marsters, Jeffrey A Bakal, Grace Y Lam, Finlay A McAlister, Christopher Power, Brain, awae117, https://doi.org/10.1093/brain/awae117, 20 April 2024 Abstract Determining the frequency and outcomes of neurological disorders associated with coronavirus disease 2019 (COVID-19) is imperative for understanding risks and for recognition of emerging neurological disorders. We investigated the susceptibility and impact of severe acute respiratory syndrome coronavirus 2 […]

Could COVID-19 Be Causing This Rare Spinal Cord Disorder?

Posted on | Posted on John Murphy | Leave a Comment on Could COVID-19 Be Causing This Rare Spinal Cord Disorder?

Can COVID-19 cause a rare spinal condition called transverse myelitis? Learn what TM is and see the evidence connecting the two conditions. The year 2020 has been one for the books: a worldwide pandemic, government shutdowns, quarantining, virtual learning, working from home, wearing masks, capacity restrictions, social distancing, you name it. COVID-19 has directly impacted […]

Study: This Diet May Reduce Your Odds for COVID-19

Posted on | Posted on John Murphy | Leave a Comment on Study: This Diet May Reduce Your Odds for COVID-19

COVID cases have surged this summer, but a new study suggests that following the Mediterranean diet might spare you from infection. In a review published Wednesday in the journal PLOS One, Indonesian researchers discovered that the healthy eating regimen, which centers on fruits, vegetables, whole grains, legumes, fish and heart-healthy fats like olive oil and nuts, lowered the risk […]