Abstract Transverse myelitis (TM) is an inflammatory disorder of the spinal cord characterized by acute or subacute development of bilateral motor, sensory, and autonomic dysfunction attributable to focal spinal cord […]
Structural Brain Alterations in Post-Acute Sequelae of SARS-CoV-2 Infection
John Murphy, CEO The COVID-19 Long-haul Foundation Abstract Post-acute sequelae of SARS-CoV-2 infection (PASC), or Long COVID, is increasingly recognized as a multisystem disorder with prominent neurological involvement. Among the […]
Long-COVID Brain Fog: Reconsidering the Centrality of Ongoing Neuroinflammation
A Mechanistic Reappraisal of Cognitive Dysfunction Following SARS-CoV-2 Infection Author: John Murphy, CEO, COVID-19 Long-haul Foundation Abstract “Brain fog” in Long COVID has often been attributed to persistent neuroinflammation driven […]
COVID-19 and the Motor–Sensory Brain: Pathobiology, Microvascular Injury, Neurophysiology, Clinical Manifestations, Therapeutic Strategies, and Long-Term Outcomes
John Murphy, CEO COVID-19 Long-haul Founndation Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), initially characterized as a respiratory pathogen, is now recognized as a systemic vascular and neurotropic disease […]
Long COVID, COVID-19 Vaccination, and the Emergence of Absence Seizures
Abstract The neurological sequelae of SARS-CoV-2 infection have emerged as among the most disabling manifestations of post-acute sequelae of COVID-19 (PASC), commonly known as Long COVID. While cognitive dysfunction, dysautonomia, […]
Persistent Viral Reservoirs and Immune Dysregulation in Long COVID
John Murphy, M.D., M.P.H., D.P.H., President Covid-19 Long-haul Foundation The Central Discovery Reshaping Post-Acute Sequelae Research Abstract Long COVID (post-acute sequelae of SARS-CoV-2 infection, PASC) has emerged as a multisystem […]
Severe cerebral amyloid angiopathy related inflammation (CAA-ri) associated with vaccination
Michael Tang 1, Jane Kim 2, Kui Kai Lau 3, Koon Ho Chan 3, PMID: 39094435, DOI: 10.1016/j.jneuroim.2024.578406 Abstract Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rapid but reversible autoimmune encephalopathy where spontaneous autoantibody reaction against amyloid beta deposited […]
Amyloid β-related angiitis of the central nervous system occurring after COVID-19 vaccination: A case report
Mayuri Kizawa 1, Yasushi Iwasaki, PMCID: PMC9791501 PMID: 36579089 Abstract BACKGROUND Although coronavirus disease 2019 (COVID-19) vaccines have been effective in controlling the COVID-19 pandemic, a variety of post-vaccination neurological complications have been reported worldwide. […]
Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation–a controlled study
Roald Omdal, Ole Bernt Lenning, Grete Jonsson, Scientific Reports , Article number: (2026) Cite this article We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript […]
Cerebral amyloid angiopathy – Related inflammation after COVID-19 vaccination: Case or causality?
Francesco Rossato a, Gianmarco Gazzola a, Valentina Carlucci a, et. al. PMCID: PMC8498485 Background and aims Cerebral amyloid angiopathy (CAA) is characterized by microangiopathy with increased susceptibility to hemorrhages. Some patients may develop an inflammatory form […]