Toward a Multisystem Endotype Framework for Post–Acute SARS-CoV-2 Disease John Murphy, M.D., M.P.H., D.P.H. President Covid-19 Long-haul Foundation Abstract Long COVID (post–acute sequelae of SARS-CoV-2 infection, PASC) has emerged as […]
Treatment Landscape in Long COVID Has Expanded Beyond “Supportive Care”
A Mechanism-Driven Reframing of Therapeutic Development in Post–Acute SARS-CoV-2 Disease John Murphy, M.D, M.P.H., D.P.H. President COVID Long-haul Foundation Conceptual Shift and Therapeutic Reclassification ABSTRACT For much of the early […]
Persistent Immune Exhaustion in Post–Acute Sequelae of SARS-CoV-2 Infection
John Murphy, M.D., M.P.H., D.P.H. President Cov-19 Long-haul Foundation Immunologic Foundations, T-cell Dysfunction, and Exhaustion Signatures Abstract Importance: Post–acute sequelae of SARS-CoV-2 infection (PASC), commonly referred to as Long COVID, […]
Biological Warfare: How a Bat Reproductive Operating System Was Forced Into Humanity
Deep in the mountains of Yunnan Province, China, in the spring of 2012, six men walked into an abandoned copper mine to clear bat guano from the walls. Bat guano […]
Persistent attenuation of lymphocyte subsets after mass SARS-CoV-2 infection
Zhengqi Jiang ∙ Tichao Shan∙ Yucan Li ∙ Heyu Ni ∙ et. al., DOI: 10.1016/j.ijid.2025.108287 External Link Also available on ScienceDirect External Link Highlights SARS-CoV-2 causes lasting immune dysregulation for over 20 months. The impact of SARS-CoV-2 on lymphocytes was especially severe in patients […]
Systemic immune dysregulation to pulmonary Impairment in long COVID
Abstract The mechanisms driving immune dysregulation in long COVID disease remain elusive. Here we integrated single-cell multiome data, immunological profiling and functional assays to investigate immune alterations across multiple cohorts. […]
Fauci & Collins Brushed Off ‘Impressive’ Data For COVID Natural Immunity
Newly released emails reveal that senior Biden administration health officials privately grappling with research suggesting recovery from Covid-19 infection provided stronger protection than vaccination alone – at the very moment the federal […]
Emails show Fauci, Collins plotting to circumvent ‘impressive’ data for COVID natural immunity
Former FDA adviser said he had meetings with feds on natural immunity as comparable to vaccination, but that they dismissed it for bureaucratic and messaging reasons. CDC official justified vaccine […]
Post–COVID-19 Immune Dysregulation and the Emergence of Methicillin-Resistant Staphylococcus aureus
John Murphy, M.D., MPH, DPH, President COVID-19 Long-haul Foundation Abstract The coronavirus disease 2019 (COVID‑19) pandemic has reshaped the global landscape of infectious diseases in ways that extend far beyond […]
COVID‑19 Vaccination and Chronic Inflammatory Disease
John Murphy, CEO, The COVID-19 Long-haul Foundation (www.covid19longhaulfoundation.org ) Abstract COVID‑19 vaccination has altered the trajectory of the pandemic, yet its implications for patients with chronic inflammatory diseases (CIDs) remain […]