Category: Vaccine News

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ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome

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Authors: ALEXANDER T. BAKERHTTPS://ORCID.ORG/0000-0001-8232-0531RYAN J. BOYDHTTPS://ORCID.ORG/0000-0002-6704-8696DAIPAYAN SARKARHTTPS://ORCID.ORG/0000-0002-4167-2108ALICIA TEIJEIRA-CRESPOCHUN KIT CHANEMILY BATESHTTPS://ORCID.ORG/0000-0003-1378-6981KASIM WARAICHHTTPS://ORCID.ORG/0000-0002-2927-7383JOHN VANTHTTPS://ORCID.ORG/0000-0003-0627-4603ERIC WILSONHTTPS://ORCID.ORG/0000-0002-4104-1445[…]MITESH J. BORADHTTPS://ORCID.ORG/0000-0003-2700-2658 +16 authors Authors Info & Affiliations Abstract Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic. As part of the largest vaccination campaign in history, ultrarare side effects not seen […]

Antigen Presentation of mRNA-Based and Virus-Vectored SARS-CoV-2 Vaccines

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Authors: Ger T. Rijkers,1,2,* Nynke Weterings,1 Andres Obregon-Henao,3 Michaëla Lepolder,1 Taru S. Dutt,3 Frans J. van Overveld,1 and Marcela Henao-Tamayo3 Abstract Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19), which has reached pandemic proportions. A number of effective vaccines have been produced, including mRNA vaccines and viral vector vaccines, which are now being implemented on a […]

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

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Authors: Yuyang Lei,1,2,*Jiao Zhang,1,2,5,*Cara R. Schiavon,8,9Ming He,5Lili Chen,2Hui Shen,5,10Yichi Zhang,5Qian Yin,2Yoshitake Cho,5Leonardo Andrade,8Gerald S. Shadel,9Mark Hepokoski,6Ting Lei,3Hongliang Wang,4Jin Zhang,7Jason X.-J. Yuan,6Atul Malhotra,6Uri Manor,8,†Shengpeng Wang,2,†Zu-Yi Yuan,1,† and John Y-J. Shyy5,† SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells. Vascular endothelium […]

THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY ROLE IN ILLNESS

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Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very […]

VAERS Summary for COVID-19 Vaccines through 11/05/2021

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Official Reported Vaccine Adverse Events in the FDA Data Base For a Complete Report of All Vaccine Reported Adverse Events Through November 5th, 2021 Click Link Below: http://vaersanalysis.info/wp-content/uploads/2021/11/VAERS-Summary-11052021-3.pdf

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalizations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

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Eric J HaasFrederick J AnguloJohn M McLaughlinEmilia AnisShepherd R SingerFarid KhanNati BrooksMeir SmajaGabriel MircusKaijie PanJo SouthernDavid L SwerdlowLuis JodarYeheskel LevySharon Alroy-PreisAuthors: During the analysis period (Jan 24 to April 3, 2021), there were 232 268 SARS-CoV-2 infections, 7694 COVID-19 hospitalizations, 4481 severe or critical COVID-19 hospitalizations, and 1113 COVID-19 deaths in people aged 16 years […]

Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study

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Authors: Sara YTartofPhDaeJeff MSlezakMSaHeidiFischerPhDaVennisHongMPHaBradley KAckersonMDbOmesh NRanasingheMPHaTimothy BFranklandMAcOluwaseye AOgunMDaJoann MZamparoMPHdSharonGrayMSdSrinivas RValluriPhDdKaijePanMSdFrederick JAnguloPhDdLuisJodarPhDdJohn MMcLaughlinPhDd Between Dec 14, 2020, and Aug 8, 2021, of 4 920 549 individuals assessed for eligibility, we included 3 436 957 (median age 45 years [IQR 29–61]; 1 799 395 [52·4%] female and 1 637 394 [47·6%] male). For fully vaccinated individuals, effectiveness against SARS-CoV-2 infections was 73% (95% CI 72–74) […]

New England Journal of Medicine

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Published Articles COOVID 2021 A collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary. https://www.nejm.org/coronavirus?query=main_nav_lg Covid-19 Vaccine Resource Center A collection of resources on Covid-19 vaccines, including published research, continuing medical education, and commentary.  https://www.nejm.org/covid-vaccine

Latest Lancet Study Exposes Limits Of Vaccines At Preventing COVID Infection

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FRIDAY, OCT 29, 2021 – 05:45 PM The Lancet has just released another study comparing the efficacy of COVID vaccines to the efficacy of protection provided by previous COVID infections. Their conclusion: while vaccines lower the risk of infections with the delta variant within households, those who are fully vaccinated are still vulnerable to a […]

Vaccinated just as likely to spread delta variant within household as unvaccinated: study

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Authors: BY CAROLINE VAKIL – 10/29/21 09:07 AM EDT People who have received COVID-19 vaccinations are able to spread the delta variant within their household despite their vaccination status just as easily as unvaccinated individuals, a new study published on Friday shows. According to the study published in The Lancet Infectious Diseases journal, people who contracted COVID-19 had a similar viral load regardless […]