Category: Genomics

Posted on | Posted on John Murphy | Leave a Comment on “Insertions and Deletions in the SARS‑CoV‑2 Genome: Structural, Translational, and Clinical Consequences Driving Infectivity and Pathology”

“Insertions and Deletions in the SARS‑CoV‑2 Genome: Structural, Translational, and Clinical Consequences Driving Infectivity and Pathology”

John Murphy, CEO The COVID-19 Long-haul Foundation Abstract Insertions and deletions (indels) in the SARS‑CoV‑2 genome have emerged as critical drivers of viral evolution, influencing infectivity, immune evasion, and clinical…[...]

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Posted on | Posted on John Murphy | Leave a Comment on 🧠 Neurovascular and Genomic Underpinnings of COVID-19 Brain Fog: A Multisystem Analysis of Etiology, Pathophysiology, and Therapeutic Targets

🧠 Neurovascular and Genomic Underpinnings of COVID-19 Brain Fog: A Multisystem Analysis of Etiology, Pathophysiology, and Therapeutic Targets

John Murphy, CEO, The COVID-19 Long-haul Foundation Abstract COVID-19 brain fog, a hallmark of post-acute sequelae of SARS-CoV-2 infection (PASC), represents a complex neurocognitive syndrome characterized by impaired memory, attention,…[...]

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Posted on | Posted on John Murphy | Leave a Comment on Sex-Based and Genetic Vulnerabilities: Hormonal Modulation, IL-6 Polymorphisms, HLA Factors, and Personalized Medicine Implications

Sex-Based and Genetic Vulnerabilities: Hormonal Modulation, IL-6 Polymorphisms, HLA Factors, and Personalized Medicine Implications

Author: John Murphy, President, COVID-19 Long-haul Foundation Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), presents with a striking female predominance and heterogeneous symptom profiles. Emerging evidence suggests…[...]

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Posted on | Posted on John Murphy | Leave a Comment on Persistent SARS-CoV-2 Spike Protein: Genomic Modulation, Immune Dysregulation, and Impaired Antibody Maturation

Persistent SARS-CoV-2 Spike Protein: Genomic Modulation, Immune Dysregulation, and Impaired Antibody Maturation

Author: John Murphy, CEO COVID 19 Long-haul Foundation Abstract The SARS-CoV-2 spike glycoprotein, central to viral entry and the target of mRNA vaccine platforms, has emerged as a persistent antigen…[...]

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Posted on | Posted on John Murphy | Leave a Comment on Genomic Convergence: Emerging Pathways, Mechanisms, and Druggable Targets in Precision Medicine for COVID Long-haul Research

Genomic Convergence: Emerging Pathways, Mechanisms, and Druggable Targets in Precision Medicine for COVID Long-haul Research

Author: John Murphy, CEO COVID-19 Long-haul Foundation Abstract The past three years have witnessed an unprecedented acceleration in genomic discovery, driven by advances in single-cell sequencing, spatial transcriptomics, and integrative…[...]

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