Antigen Presentation of mRNA-Based and Virus-Vectored SARS-CoV-2 Vaccines

Authors: Ger T. Rijkers,1,2,* Nynke Weterings,1 Andres Obregon-Henao,3 Michaëla Lepolder,1 Taru S. Dutt,3 Frans J. van Overveld,1 and Marcela Henao-Tamayo3 Abstract Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19), which has…[...]

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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

Authors: Yuyang Lei,1,2,*Jiao Zhang,1,2,5,*Cara R. Schiavon,8,9Ming He,5Lili Chen,2Hui Shen,5,10Yichi Zhang,5Qian Yin,2Yoshitake Cho,5Leonardo Andrade,8Gerald S. Shadel,9Mark Hepokoski,6Ting Lei,3Hongliang Wang,4Jin Zhang,7Jason X.-J. Yuan,6Atul Malhotra,6Uri Manor,8,†Shengpeng Wang,2,†Zu-Yi Yuan,1,† and John Y-J. Shyy5,† SARS-CoV-2 (severe acute…[...]

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Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study

Authors: Sara YTartofPhDaeJeff MSlezakMSaHeidiFischerPhDaVennisHongMPHaBradley KAckersonMDbOmesh NRanasingheMPHaTimothy BFranklandMAcOluwaseye AOgunMDaJoann MZamparoMPHdSharonGrayMSdSrinivas RValluriPhDdKaijePanMSdFrederick JAnguloPhDdLuisJodarPhDdJohn MMcLaughlinPhDd Between Dec 14, 2020, and Aug 8, 2021, of 4 920 549 individuals assessed for eligibility, we included 3 436 957 (median…[...]

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